Abdominal lymph flow in an endotoxin sepsis model: Influence of spontaneous breathing and mechanical ventilation*

Lattuada, Marco; Hedenstierna, Göran

doi:10.1097/01.ccm.0000242158.28619.09

Cited by 43 publications

(20 citation statements)

References 20 publications

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“…Both positive pressure ventilation and intrathoracic insufflation increase the intrathoracic pressure and should have negatively affected the MB flow through the TD. Lattuada and Hedenstiema (2006) also concluded that spontaneous breathing increases lymph flow in pigs in comparison to mechanically-ventilated pigs.…”

Section: Discussionmentioning

confidence: 99%

“…Also, we hypothesised that the previous injection of iohexol into the left popliteal lymph node should not have further influenced the lymphatic flow, because the interval between the two injections was more than 30 min. As lymphatic flow in pigs has been estimated to be between 2.5 and 6.9 ml/min (Lattuada and Hedenstiema 2006) iohexol should have disappeared from the lymph vessels at the time of MB injection.…”

Section: Discussionmentioning

confidence: 99%

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Visualisation of the thoracic duct after popliteal lymph node injection in the pig: comparison of radiographic and thoracoscopic techniques

Vnuk¹,

Kurilj²,

Matičić³

et al. 2014

Vet. Med. - Czech

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Radiographic contrast studies have been recommended to identify the thoracic duct (TD) and its branches before and after surgery for total occlusion. The macroscopic identification of the TD and its branches during surgery usually involves injection of methylene blue (MB). Radiographic contrast and methylene blue can be injected into different anatomical structures (lymph node, lymph vessel, s.c.). The purpose of this study was to compare two different techniques (radiographic and thoracoscopic) for visualisation of the TD after intrapopliteal lymph node injection in the pig. Six piglets from the same litter (two males and four females), two months of age were used. Iohexol at 245 mg/ml was injected into the left popliteal lymph node (LN) under general anaesthesia; hindlimb, abdominal, and thoracic radiographs were taken. A 0.25% methylene blue solution was injected into the right popliteal lymph node and the thoracic duct colouration was assessed thoracoscopically. The thoracic duct was visualised radiographically in one out of six pigs after iohexol injection and thoracoscopically in five out of six pigs after methylene blue injection. The difference was statistically significant (P = 0.040). Popliteal LN lymphangiography using iohexol at 245 mg/ml in piglets should not be the recommended method for TD visualisation. Intrapopliteal injection of a 0.25% solution of methylene blue is recommended as a method of TD visualisation prior to thoracic duct ligation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Visualisation of the thoracic duct after popliteal lymph node injection in the pig: comparison of radiographic and thoracoscopic techniques

Vnuk¹,

Kurilj²,

Matičić³

et al. 2014

Vet. Med. - Czech

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“…TD drainage was previously described as research tool used in mice and rats [3], rabbits [4], dogs [5], sheep [6], and pigs [7]. Such intervention can be surgically demanding, especially in small-animal models [3,8].…”

Section: Introductionmentioning

confidence: 99%

Thoracic Duct Narrowing—Innovative Technique Restraining Weight Gain in Rats

et al. 2015

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“…Lattuada et al [57] found that endotoxin increased thoracic lymph flow in anesthetised pigs, whereas IAH decreased lymph flow irrespective of whether the pigs were septic or not.…”

Section: Abdominal Lymph Flow In Critically Ill Patients With Iahmentioning

confidence: 99%

“…Therefore, in critically ill patients with abnormal or missing peristalsis, this clearance of interstitial fluid is impaired. Furthermore, mechanical ventilation with high intra-thoracic pressure (ITP) can affect lymph flow, by impeding lymphatic return, while the concomitant increase in splanchnic venous pressure may result in a net increase in lymph production favouring oedema formation [57,58].…”

Section: Abdominal Lymph Flow In Critically Ill Patients With Iahmentioning

confidence: 99%

Abdominal pressure and gastrointestinal function: an inseparable couple?

Blaser¹,

Malbrain²,

Regli³

2017

Anaesthesiol Intensive Ther

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Evaluating the degree of organ dysfunction is a cornerstone in distinguishing patients with critical illness from those without. However, evaluation of the gastrointestinal function in critically ill patients is not unified, and is still largely based on subjective clinical evaluation. Although intra-abdominal pressure has been proposed as a parameter to facilitate monitoring of abdominal compartment in critical illness, the interactions between intra-abdominal pressure and gastrointestinal function are poorly clarified. The aim of this current review is to describe interactions and associations between gastrointestinal dysfunction and intra-abdominal pressure from a pathophysiological and clinical point of view.

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Abdominal lymph flow in an endotoxin sepsis model: Influence of spontaneous breathing and mechanical ventilation*

Abstract: Endotoxin increases lymph flow from the abdomen. Mechanical ventilation with high PEEP impedes lymph drainage and could increase lymph production. Spontaneous breathing increases flow and improves drainage of abdominal edema.

Cited by 43 publications

References 20 publications

Visualisation of the thoracic duct after popliteal lymph node injection in the pig: comparison of radiographic and thoracoscopic techniques

Visualisation of the thoracic duct after popliteal lymph node injection in the pig: comparison of radiographic and thoracoscopic techniques

Thoracic Duct Narrowing—Innovative Technique Restraining Weight Gain in Rats

Abdominal pressure and gastrointestinal function: an inseparable couple?

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