Abdominal mesotherapy injection extended the absorption of follicle-stimulating hormone

Hsu, Chao Chin; Kuo, Hsin-Chih; Hsu, Chao‐Tien; Gu, Qing

doi:10.1016/j.fertnstert.2010.12.007

Cited by 9 publications

(14 citation statements)

References 15 publications

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“…These data confirm the many potential clinical advantages of using intradermal injection—dose reduction, reduced number of injections needed to maintain elevated FSH levels, and reduced risk of adverse events [28]. The superficial layer of the skin appears to suggest a sort of an innate “slow-release system” (to be demonstrated with other preclinical and clinical studies), and it is interesting to note that the terminology “local intradermal therapy” is used to highlight the fact that it modulates the absorption and diffusion of drugs at a local level [5], even if till today studies were not produced with the technique of microdialysis.…”

Section: Reasons To Consider Mesotherapy In Pain Managementsupporting

confidence: 62%

Role of Mesotherapy in Musculoskeletal Pain: Opinions from the Italian Society of Mesotherapy

Mammucari

Gatti

Maggiori

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Mesotherapy is the injection of active substances into the surface layer of the skin. This method allows a slower spread, higher levels, and longer lasting effects of drugs in the tissues underlying the site of injection (skin, muscle, and joint) compared with those following intramuscular injection. This technique is useful when a local pharmacological effect is required and relatively high doses of drug in the systemic circulation are not. Mesotherapy should only be undertaken following a complete clinical workup and subsequent diagnosis. Encouraging results have been reported in randomized, controlled clinical trials and in observational studies involving patients with various forms of musculoskeletal pain. Recommendations by experts from the Italian Society of Mesotherapy for appropriate use of mesotherapy in musculoskeletal pain and an algorithm for treating localized painful conditions are provided.

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Section: Reasons To Consider Mesotherapy In Pain Managementsupporting

confidence: 62%

Role of Mesotherapy in Musculoskeletal Pain: Opinions from the Italian Society of Mesotherapy

Mammucari

Gatti

Maggiori

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Furthermore, mixed literature is available regarding the aneuploidy rates in preimplantation genetic screening using array CGH or SNP in women receiving higher or lower doses of gonadotropins for the COS (25)(26)(27). With the aim of reducing the physical, emotional, and financial burden of patients, a more patient-friendly approach, including a lower dose of gonadotropins and a reduced number of injections, should be taken into account (19,28,29). In the present subject, direct injection of gonadotropins into the ovary induced restoration of the ovulatory function without any adverse effect.…”

Section: Discussionmentioning

confidence: 99%

Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report

Hsu

et al. 2020

Front. Endocrinol.

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The conception rates among women with premature ovarian insufficiency (POI) remain extremely low. To achieve a successful pregnancy, most of these women have to receive donor oocytes through IVF treatment. Ovarian administration of platelet-rich plasma (PRP) has been recently applied to enhance the ovulatory function in women with poor ovarian response. However, no live birth has been reported for this application in patients with POI. In this study, we present a 37-year-old woman with POI who had secondary amenorrhea for 6 months. The clinical manifestations and evaluation of this women with a diminished ovarian function were an undetectable serum level of AMH (<0.02 ng/mL) and an elevated serum level of FSH (63.65 mIU/mL). A single dose of autologous PRP (extracted from 40 mL of peripheral blood) in combination with gonadotropin (150IU rFSH/75 IU rLH) was directly injected into the stroma of bilateral ovaries via vaginal sonographic guidance. Following the treatment, this patient received controlled ovarian stimulation and IVF during the successive months. Following embryo culture, three cleavage-stage embryos were transferred, leading to a successful pregnancy, which later resulted in the live birth of twins. This case report provides one example of alternative therapy that allows POI patients to use autologous oocytes in IVF treatment.

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“…Nevertheless, our results show that mesotherapy could provide a valuable contribution to the treatment of pain and sensory symptoms in CTS, particularly among those patients with less severe clinical signs (SWQCS score of 16 or less), and its effectiveness seems to be long lasting. Previous studies demonstrated that injection of drugs via mesotherapy into the dermis slowly achieves higher local concentrations in the underlying tissuses, as compared to intramuscular or subcutaneous administration [17,28]. Therefore, mesotherapy allows the use of reduced dosage of anti-inflammatory drugs, minimizing their adverse events.…”

Section: Discussionmentioning

confidence: 99%

Intradermal Therapy (Mesotherapy) for the Treatment of Acute Pain in Carpal Tunnel Syndrome: A Preliminary Study

2014

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BackgroundThe carpal tunnel syndrome (CTS) is the most common cause of severe hand pain. In this study we treated acute pain in CTS patients by means of local intradermal injections of anti-inflammatory drugs (mesotherapy).MethodsIn twenty-five patients (forty-five hands), CTS diagnosis was confirmed by clinical and neurophysiological examination prior to mesotherapy. A mixture containing lidocaine 10 mg, ketoprophen lysine-acetylsalycilate 80 mg, xantinol nicotinate 100 mg, cyanocobalamine 1,000 mcg plus injectable water was used. Sites of injection were three parallel lines above the transverse carpal ligament and two v-shaped lines, one at the base of the thenar eminence, and the other at the base of the hypothenar eminence.ResultsThe day after the treatment, all but four patients reported a significant reduction in pain and paresthesias. After 12 months, 17 patients had a complete pain relief, eight patients reported recurrence of pain and sensory symptoms and four out of them underwent surgical treatment.ConclusionsWith the obvious limits of a small-size open-label study, our results suggest that mesotherapy can temporary relieve pain and paresthesias in most CTS patients and in some cases its effect seems to be long-lasting. Further controlled studies are needed to confirm our preliminary findings and to compare mesotherapy to conventional approaches for the treatment of CTS.

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Abdominal mesotherapy injection extended the absorption of follicle-stimulating hormone

Cited by 9 publications

References 15 publications

Role of Mesotherapy in Musculoskeletal Pain: Opinions from the Italian Society of Mesotherapy

Role of Mesotherapy in Musculoskeletal Pain: Opinions from the Italian Society of Mesotherapy

Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report

Intradermal Therapy (Mesotherapy) for the Treatment of Acute Pain in Carpal Tunnel Syndrome: A Preliminary Study

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