Abdominal obesity and insulin resistance after an episode of acute pancreatitis

Singh, Ruma G.; Pendharkar, Sayali A.; Cervantes, Aya; Cho, Jaelim; Miranda-Soberanis, Víctor; Petrov, Maxim S.

doi:10.1016/j.dld.2018.04.023

Cited by 35 publications

(25 citation statements)

References 52 publications

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“…However, the magnitude of incretin-like activity of these hormones is small in type 2 diabetes. Further, fasting levels of these hormones were not found to be significantly associated with abnormal glucose metabolism in individuals after acute pancreatitis [37].…”

Section: Associations Between Gut Hormones and Indices Of Insulin Secmentioning

confidence: 78%

“…Further, BMI contributed 13.0 and 20.8 % to variance in circulating levels of fasting and peak postprandial oxyntomodulin in individuals with NODAP, respectively (i. e., about 2 times more compared with healthy controls). Although evidence shows that GIP is associated with fat accumulation [34], studies conducted until now have largely been limited to either investigations of general and abdominal adiposity (as determined by waist circumference or BMI [35,36]) or a particular fat depot (e. g., liver fat [37]). The present study is the first study to investigate the associations between gut hormones and a comprehensive panel of body fat parameters (▶table 1), on the basis of which it can be inferred that higher liver fat %, and not pancreatic fat %, BMI, SFV, or VFV, appears to be associated with increased GIP levels in individuals with NODAP.…”

Section: Associations Between Gut Hormones and Indices Of Insulin Secmentioning

confidence: 99%

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Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis

et al. 2018

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The study was aimed to investigate gut hormone responses to mixed meal test in individuals with new-onset prediabetes or diabetes after acute pancreatitis (cases) compared with healthy controls, and the effect of body fat parameters. A total of 29 cases and 29 age- and sex-matched healthy controls were recruited. All participants were given standard mixed meal drink and blood samples were collected to measure dipeptidyl peptidase IV, gastric inhibitory peptide, glucagon like peptide-1, insulin, oxyntomodulin, and peptide YY. Body fat parameters were measured using magnetic resonance imaging. Repeated measures and linear regression analyses were conducted in unadjusted and adjusted models. Gastric inhibitory peptide levels were significantly higher whereas oxyntomodulin levels were significantly lower in cases compared with controls in both the unadjusted (p<0.001 and p<0.001, respectively) and adjusted (p<0.001 and p<0.001, respectively) models. In cases, liver fat % contributed up to 13.4% (vs. 2.9% in controls) to variance in circulating levels of gastric inhibitory peptide whereas body mass index - up to 20.8% (vs. 9.9% in controls) in circulating levels of oxyntomodulin. New-onset prediabetes/diabetes after acute pancreatitis is characterised by increased levels of gastric inhibitory peptide and decreased levels of oxyntomodulin. Further, liver fat % and body mass index appear to be the body fat parameters that contribute most significantly to gastric inhibitory peptide and oxyntomodulin levels, respectively.

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Section: Associations Between Gut Hormones and Indices Of Insulin Secmentioning

confidence: 78%

Section: Associations Between Gut Hormones and Indices Of Insulin Secmentioning

confidence: 99%

Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis

et al. 2018

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“…At least two out of five individuals develop new‐onset prediabetes and diabetes after AP (NODAP) . Moreover, excess abdominal adiposity also contributes to low‐grade inflammation after AP . However, to the best of our knowledge, no study has investigated comprehensively the associations between IFD and body composition as well as indices of insulin secretion, indices of insulin sensitivity, incretins and related peptides in individuals with prediabetes and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…9 Moreover, excess abdominal adiposity also contributes to low-grade inflammation after AP. 7,10 However, to the best of our knowledge, no study has investigated comprehensively the associations between IFD and body composition as well as indices of insulin secretion, indices of insulin sensitivity, incretins and related peptides in individuals with prediabetes and diabetes. The aim of the present study was to investigate body composition and insulin traits as biomarkers of IFD in NODAP and healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of body composition and insulin traits associated with intra‐pancreatic fat deposition in healthy individuals and people with new‐onset prediabetes/diabetes after acute pancreatitis

Singh

Nguyen

DeSouza

et al. 2018

Diabetes Obesity Metabolism

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Current knowledge of biomarkers of intra-pancreatic fat deposition (IFD) is limited. We aimed to analyse comprehensively body composition and insulin traits as biomarkers of IFD in healthy normoglycaemic individuals as well as in individuals with new-onset prediabetes or diabetes after acute pancreatitis (NODAP). A total of 29 healthy individuals and 34 individuals with NODAP took part in this cross-sectional study. The studied biomarkers belonged to the following domains: body composition (anthropometric and MRI-derived variables); indices of insulin secretion; indices of insulin sensitivity; incretins and related peptides; and pancreatitis-related factors. All MRI-derived variables (including IFD) were measured using ImageJ software. Univariate and step-wise regression analyses were conducted to determine variables that best explained variance in IFD. Visceral fat volume and oxyntomodulin were the best biomarkers of IFD in normoglycaemic healthy individuals, contributing to 64% variance. The Raynaud index was the best biomarker of IFD in individuals with NODAP, contributing to 20% variance. Longitudinal studies are warranted to investigate the cause and effect relationship between oxyntomodulin and IFD in healthy individuals, as well as insulin sensitivity and IFD in individuals with NODAP.

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“…Fifth, DM status prior to AP was not considered in this study. Future studies are required to determine whether the observed associations hold true in new-onset diabetes after acute pancreatitis [66][67][68][69][70][71][72][73]. Last, all measures have been completed in the fasting state only.…”

Section: Discussionmentioning

confidence: 99%

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis

Gold-Smith

Singh

Petrov

2019

Exp Clin Endocrinol Diabetes

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Aim The study aimed to investigate the associations between glycaemic control after acute pancreatitis and gastrointestinal motility, using plasma motilin concentration and gastroparesis cardinal symptom index score as proxies. Methods This cross-sectional study recruited a total of 93 individuals after acute pancreatitis. Gastroparesis cardinal index scores, demographic and anthropometric factors, as well as pancreatitis-related factors were analysed. Fasting venous blood was collected to measure motilin, glycated haemoglobin, and fasting blood glucose. Linear regression analyses were conducted to investigate the associations between glycaemic control and gastrointestinal motility in unadjusted and adjusted models. Results Motilin was significantly higher in individuals with diabetes across all adjusted models, with the highest ß-coefficient (95% confidence interval) of 588.89 (138.50, 1039.28); P=0.010. Fasting blood glucose was significantly associated with motilin across all models, with the highest ß-coefficient (95% confidence interval) of 156.30 (55.49, 257.10); P=0.002. Glycated haemoglobin was significantly associated with motilin in one adjusted model with ß-coefficient (95% confidence interval) of 18.78 (1.53, 36.02); P=0.033. Gastroparesis cardinal symptom index was not significantly associated with any measure of glycaemic control. Conclusions Diabetes in individuals after acute pancreatitis appears to be characterised by elevated plasma motilin but not gastroparesis cardinal symptom index. The role of motilin in this setting warrants further investigations.

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Abdominal obesity and insulin resistance after an episode of acute pancreatitis

Cited by 35 publications

References 52 publications

Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis

Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis

Comprehensive analysis of body composition and insulin traits associated with intra‐pancreatic fat deposition in healthy individuals and people with new‐onset prediabetes/diabetes after acute pancreatitis

Elevated Circulating Levels of Motilin are Associated with Diabetes in Individuals after Acute Pancreatitis

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