Abdominal obesity and insulin resistance in patients with type 2 diabetes in a Swedish community

Bari, Muhammad Rizuanul; Östgren, Carl Johan; Råstam, Lennart; Lindblad, Ulf

doi:10.1080/02813430601035290

Cited by 8 publications

(3 citation statements)

References 28 publications

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“…In addition, it was concluded in Model 1 and Model 2 that high-density lipoprotein was still an independent risk factor for HOMA-IR, so lipid metabolism may play an important role in the pathogenesis of insulin resistance. Consistent with previous studies, insulin resistance was significantly correlated with obesity 31 and lipid profile. The TG and glucose index (TyG index) is a good predictor of the insulin resistance 32 and triglycerides can interfere with islet beta cells and insulin-producing islet cells in the normal signal transmission, so as to form in human insulin resistance.…”

Section: Discussionsupporting

confidence: 91%

Associations Between Serum Folate Level and HOMA-IR in Chinese Patients with Type 2 Diabetes Mellitus

Yang¹,

Hu²,

Wang³

et al. 2023

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Background Adequate intake of folic acid (FA) has been proven essential for metabolism, cellular homeostasis, and antioxidant effects in diabetic patients. Our aim was to evaluate the association between serum folate levels and the risk of insulin resistance in patients with type 2 diabetes mellitus (T2DM) and to provide new ideas and approaches for reducing the risk of T2DM. Methods This was a case–control study involving 412 participants (206 with T2DM). Anthropometric parameters, islet function, biochemical parameters and body composition of T2DM group and control group were determined. Correlation analysis and logistic regression were used to evaluate the risk factors associated with the onset of insulin resistance in T2DM. Results The folate levels in type 2 diabetic patients with insulin resistance were significantly lower than those in patients without insulin resistance. Logistic regression showed that FA and high-density lipoprotein were independent influencing factors for insulin resistance in diabetic patients ( P < 0.05). After adjusting for confounding factors, the degree of insulin resistance in diabetic patients was in a significant inverse relationship with folate levels ( P < 0.05). We also found that below the serum FA threshold of 7.09 ng/mL insulin resistance was significantly more elevated. Conclusion Our findings suggest that the risk of insulin resistance increases with the decrease in serum FA levels in T2DM patients. Monitoring folate levels in these patients and FA supplementation are warranted preventive measures.

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Section: Discussionsupporting

confidence: 91%

Associations Between Serum Folate Level and HOMA-IR in Chinese Patients with Type 2 Diabetes Mellitus

Yang¹,

Hu²,

Wang³

et al. 2023

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“…Several studies showed that one reason behind all of these complications is an elevated level of proinflammatory cytokines [ 13 ]. An impaired lipid profile and the accumulation of fatty tissues, especially in the abdominal cavity, are among the most prevalent metabolic disorders of T2DM [ 14 ]. The adipose tissue is currently considered as endocrine tissue due to its role in inflammation and the production of various cytokines, which lead to changes in the metabolic status [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

APO A2 -265T/C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus

et al. 2016

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BackgroundApolipoprotein A2 (APO A2) is the second most abundant structural apolipoprotein in high density lipoprotein. Several studies have examined the possible effect of APO A2 on atherosclerosis incidence. Due to the role of inflammation in atherosclerosis, we aimed to determine the relationship between APO A2 -265T/C polymorphism and inflammation as a risk factor in type 2 diabetes mellitus (T2DM) patients.MethodsIn total, 180 T2DM patients, with known APO A2 -265T/C polymorphism, were recruited for this comparative study and were grouped equally based on their genotypes. Dietary intakes, anthropometric parameters, lipid profile, and inflammatory markers (i.e., pentraxin 3 [PTX3], high-sensitivity C-reactive protein [hs-CRP], and interleukin 18) were measured. The data were analyzed using an independent t-test, a chi-square test, and the analysis of covariance.ResultsAfter adjusting for confounding factors, in the entire study population and in the patients with or without obesity, the patients with the CC genotype showed higher hs-CRP (P=0.001, P=0.008, and P=0.01, respectively) and lower PTX3 (P=0.01, P=0.03, and P=0.04, respectively) in comparison with the T allele carriers. In the patients with the CC genotype, no significant differences were observed in the inflammatory markers between the obese or non-obese patients. However, regarding the T allele carriers, the plasma hs-CRP level was significantly higher in the obese patients compared to the non-obese patients (P=0.01).ConclusionIn the T2DM patients, the CC genotype could be considered as a risk factor and the T allele as a protective agent against inflammation, which the latter effect might be impaired by obesity. Our results confirmed the anti-atherogenic effect of APO A2, though more studies are required to establish this effect.

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“…Insulin resistance, a key determinant of metabolic syndrome 1 2 3 , is an important risk factor for type 2 diabetes 1 and cardiovascular diseases 4 5 . Adiposity, a major determinant of insulin resistance 6 7 8 , and its distribution measures have been shown to be associated with insulin resistance by a number of studies 7 9 10 11 12 13 14 15 16 17 18 19 . However, to what extent various adipose tissue depots and obesity indices are associated with insulin resistance has not been systematically evaluated.…”

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confidence: 99%

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

Zhang

et al. 2015

Sci Rep

135

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Fat distribution is strongly associated with insulin resistance, a risk factor for type 2 diabetes and cardiovascular diseases. However, associations of different adipose tissue depots or/and obesity indices with insulin resistance have not been systematically evaluated. In this study we examined associations of different adipose tissue depots/obesity indices with insulin resistance, as measured by homeostatic model assessment of insulin resistance (HOMA-IR) in observational studies. A total of 40 studies with 56 populations and 29 adipose tissue depots/obesity indices were included in the meta-analysis. There were strong correlation between HOMA-IR and visceral fat mass (r = 0.570, 95% confidence interval(CI): 0.424~0.687), total fat mass (r = 0.492, 95%CI: 0.407~0.570), body mass index (r = 0.482, 95%CI: 0.445~0.518) and waist circumference (r = 0.466, 95%CI: 0.432~0.500), except lower extremity fat (r = 0.088, 95%CI: −0.116~0.285). Sample size, diabetic status, gender, mean of body mass index, and race contributed to heterogeneity of these associations. This study showed a positive correlation between insulin resistance and most adipose tissue depots/obesity indices, and the strongest association is for visceral fat mass.

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Abdominal obesity and insulin resistance in patients with type 2 diabetes in a Swedish community

Cited by 8 publications

References 28 publications

Associations Between Serum Folate Level and HOMA-IR in Chinese Patients with Type 2 Diabetes Mellitus

Associations Between Serum Folate Level and HOMA-IR in Chinese Patients with Type 2 Diabetes Mellitus

APO A2 -265T/C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

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