Abdominal Pain and Sicklemia in a Patient With Sickle Cell Trait

Thrombotic thrombocytopenic purpura in a patient with sickle cell crisis

“…Three similar cases [2,3,6] have been reported in the literature in which TTP or a multiorgan failure syndrome was diagnosed in patients with SCD thought to have a sickle cell-related crisis. The patient described by Geigel and Francis [3] had a classical episode of TTP in addition to his pain crisis of SCD.…”

“…The patient described by Geigel and Francis [3] had a classical episode of TTP in addition to his pain crisis of SCD. Prichard et al [6] described a patient with the sickle cell trait and TTP, with abdominal pain thought to be secondary to the pain crisis, who was found to have a perforated duodenal ulcer. In the case reported by Chinowsky [2], there was also some confusion regarding the correct diagnosis on admission; an SCD crisis was considered at first and TTP was subsequently diagnosed.…”

“…The combination of an SCD crisis with thrombotic thrombocytopenic purpura (TTP) has been reported only rarely [2,3,6]. We report the case of a patient with an SCD hemolytic crisis and TTP.…”

Coagulopathy and functional hyposplenism during an episode of thrombotic thrombocytopenic purpura in a HgbS/β+‐thalassemia patient

“…We present here an acute case of TTP in a heterozygote HgbS/ β + ‐thalassemia patient complicated by DVT and functional hyposplenism. Other case reports have described both patients presenting during a sickle cell crisis with subsequent development of TTP , and, even more diagnostically challenging, episodes of TTP masquerading as a pain crisis . Chehal et al.…”

“…Prichard et al. have proposed that the minimal amount of sickling seen on microscopy may be the result of low oxygen conditions in the thrombosed microcirculation rather than the primary pathology.…”