Abdominal Pain-Related Functional Gastrointestinal Disorder and Disorders of Brain–Gut Interactions

Febo‐Rodriguez, Liz; Saps, Miguel

doi:10.1007/978-3-031-15229-0_37

Cited by 1 publication

(1 citation statement)

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“…These disorders can negatively affect children's quality of life and healthcare costs. CY treatment emerges as a non-invasive and inexpensive option for primary care and gastroenterology practices for children diagnosed with FGIDs [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

A novel compounded cyproheptadine hydrochloride oral solution: Accelerated stability study and effects on glucose and lipid metabolism in Wistar rats

Ferreira da Costa,

Silveira Cunha,

Gordilho

et al. 2024

Sci. Plena

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The present study developed a compounded oral solution (COS) containing an active component cyproheptadine hydrochloride (CY) in association with pharmaceutical adjuvants. The main objective is to demonstrate the stability of this solution and the in vivo effects on serum and liver parameters of glucose and lipid metabolism. After 180 days of analysis the COS showed physicochemical stability (pH and specific gravity) when submitted to different temperatures (24 °C and 40 °C), but the chemical stability, presented by the content of CY (%) in the formulation, showed that the degradation rate of CY increased 20x when submitted to a stress condition (40 °C). Male Wistar rats were treated with IOS 1.5 (industrial oral solution 1.5 mg.kg-1) or saline for 21 days and IOS 5.0 or COS (5 mg.kg-1) or placebo by gavage for 23 days. Treatment with IOS 1.5 increased liver cholesterol by 30 % without changing liver and body weight in this group. In contrast, treatment with IOS and COS (5 mg.kg-1) increased final body weight by 8 % compared to placebo. Interestingly, the COS group had increased liver glycogen accompanied by reduced food intake compared to IOS. However, COS and IOS 5.0 did not induce changes in adipose tissue weight, liver weight, as well as serum glucose, triacylglycerol and cholesterol levels. This work provides us with data that prove the stability of the compound solution at room temperature, as well as inducing an increase in the final body weight of rats with no alteration in glucose and lipid metabolism.

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