Abdominal Pediatric Cancer Surveillance Using Serial Computed Tomography: Evaluation of Organ Absorbed Dose and Effective Dose

Lam, Diana L.; Wootton‐Gorges, Sandra L.; McGahan, John P.; Stern, Robin L; Boone, John M.

doi:10.1053/j.seminoncol.2010.11.009

Cited by 4 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three independent parameters were extrapolated from all the binarized ROIs for the multimodal and multiscale comparative analysis [ 7 , 20 ]. The bone volume fraction (BVF) was calculated as the ratio between bone volume and total volume.…”

Section: Methodsmentioning

confidence: 99%

“…The segmentation of the µCT images was straightforward, since the contrast was high and the voxel size was smaller than the trabecular thickness. Three independent parameters were extrapolated from all the binarized ROIs for the multimodal and multiscale comparative analysis [7,20]. The bone volume fraction (BVF) was calculated as the ratio between bone volume and total volume.…”

Section: Bone Morphological Quantificationmentioning

confidence: 99%

“…Magnetic Resonance Imaging (MRI), quantitative computed tomography (qCT), and high-resolution peripheral computed tomography (HRpQCT) can be used to assess bone microarchitecture. Whereas qCT and HRpQCT are highly radiative techniques (>100 times larger than DXA) [7,8], MRI is recognized as totally non-invasive (Figure 1). So far, most of the MRI studies on bone microstructure have been carried out at conventional (1.5T) and high (3T) magnetic fields.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Validation and Optimization of Proximal Femurs Microstructure Analysis Using High Field and Ultra-High Field MRI

et al. 2021

View full text Add to dashboard Cite

Trabecular bone could be assessed non-invasively using MRI. However, MRI does not yet provide resolutions lower than trabecular thickness and a comparative analysis between different MRI sequences at different field strengths and X-ray microtomography (μCT) is still missing. In this study, we compared bone microstructure parameters and bone mineral density (BMD) computed using various MRI approaches, i.e., turbo spin echo (TSE) and gradient recalled echo (GRE) images used at different magnetic fields, i.e., 7T and 3T. The corresponding parameters computed from μCT images and BMD derived from dual-energy X-ray absorptiometry (DXA) were used as the ground truth. The correlation between morphological parameters, BMD and fracture load assessed by mechanical compression tests was evaluated. Histomorphometric parameters showed a good agreement between 7T TSE and μCT, with 8% error for trabecular thickness with no significative statistical difference and a good intraclass correlation coefficient (ICC > 0.5) for all the extrapolated parameters. No correlation was found between DXA-BMD and all morphological parameters, except for trabecular interconnectivity (R2 > 0.69). Good correlation (p-value < 0.05) was found between failure load and trabecular interconnectivity (R2 > 0.79). These results suggest that MRI could be of interest for bone microstructure assessment. Moreover, the combination of morphological parameters and BMD could provide a more comprehensive view of bone quality.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Bone Morphological Quantificationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Validation and Optimization of Proximal Femurs Microstructure Analysis Using High Field and Ultra-High Field MRI

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Each scan provides approximately 10 to 15 millisievert of ionizing radiation, the equivalent of 5 years of background radiation. [6][7][8] The diagnostic interventions used can result in deleterious health effects 9 ; the repeating schedule of these scans significantly increases radiation exposure in a young patient population with an otherwise long life expectancy and may contribute to an increased risk of second malignant neoplasms (SMNs), as suggested by population-based studies. 10,11 Miglioretti et al 11 reported the lifetime attributable risk of cancer per 10,000 CT scans to be between 0.5 and 30.5, with the highest risk of radiation-induced solid tumor development with abdomen/pelvic CT, which is frequently used in the surveillance of MGCTs.…”

Section: Introductionmentioning

confidence: 99%

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group

Fonseca

Xia

Lorenzo

et al. 2019

JCO

View full text Add to dashboard Cite

PURPOSE To investigate relapse detection methods among children and adolescents with nongerminomatous malignant germ cell tumors (MGCTs) and to determine whether tumor markers alone might be sufficient for surveillance. METHODS We retrospectively reviewed all patients enrolled in a phase III, single-arm trial for low-risk and intermediate-risk MGCTs. The method used to detect relapse was assessed based on case report forms, tumor markers, imaging, and pathology reports. Relapses were classified into one of two categories on the basis of whether they were (1) detectable by tumor marker elevation or (2) not detectable by tumor markers. RESULTS A total of 302 patients were enrolled, and 284 patients had complete data for review. Seven patients had normal tumor markers at initial diagnosis, and none experienced a relapse. At a median follow-up of 5.3 years, 48 patients (16.9%) had experienced a relapse. After central review, 47 of 48 relapses (98%) were detected by tumor marker elevation. Of the 47 patients, 16 (33.3%) had abnormal tumor markers with normal/unknown imaging, 31 patients (64.6%) had abnormal tumor markers with abnormal imaging, and one patient (2.1%) had abnormal imaging with unknown marker levels at relapse. CONCLUSION Tumor marker elevation is a highly sensitive method of relapse surveillance, at least among children and adolescents with tumor marker elevation at initial diagnosis. Eliminating exposure to imaging with ionizing radiation may enhance the safety of relapse surveillance in patients treated for MGCT.

show abstract

“…The use of CT in a cancer surveillance protocol was used as an example of a paediatric patient who had kidney cancer, with surgery and radiation therapy. The active use of diagnostic CT scans lead to a total of 50 CT scans during a seven year period and it was estimated that the patient received an organ dose of 114 mGy to 872 mGy [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Organ Dose by Direct and Indirect Measurements for a Wide Bore X-Ray Computed Tomography Unit That Used in Radiotherapy

Cakmak¹,

Tunçel²,

Sindir³

2015

IJMPCERO

View full text Add to dashboard Cite

The aim of this study was to investigate the organ doses of patients undergoing computed tomography (CT) examination using the wide bore General Electric (GE) "Light Speed RT" unit. The head, chest and pelvic regions of the Rando-phantom were scanned with 120 kV, 200 mA, and 2.5 mm slice thickness for helical and axial modes. Thermoluminescent Dosimeter (TLD) pairs were used for the dosimetry of 10 organs. TL-counts were converted to dose by using CTDIcenter dose on CT-phantom. For the calculation of the organ doses, the ImPACT software was utilized by entering CTDIair (100 mAs) in small and large field of view (26.43 and 21.17 mGy respectively). The in-field dose ranges in helical and axial modes were 64.3 -38 mGy and 47.6 -19.7 mGy in head, 48.3 -14.1 mGy and 34.1 -10 mGy in chest, 28.4 -10.2 mGy and 21 -8.5 mGy in pelvic, respectively. The organ doses from software and TLD were compared and tailored as the in-field and the out-field radiation. First results showed that the organ dose was relatively higher in the helical mode on both direct and indirect measurement. The in-field organ dose differences between TLD and software were seen. In helical and axial modes, the dose differences ranged from +1 to +13.3 and −8.3 to +9.6 mGy for head exam, +1.1 to +15.3 and +0.3 to +9.1 mGy for chest, and −21.7 to +1.9 and −15.5 to +1.8 mGy for pelvic. The availability of this program for organ dose calculations by measuring CTDIair value for CT device used in the radiotherapy would be considered valuable.

show abstract

Abdominal Pediatric Cancer Surveillance Using Serial Computed Tomography: Evaluation of Organ Absorbed Dose and Effective Dose

Cited by 4 publications

References 13 publications

Validation and Optimization of Proximal Femurs Microstructure Analysis Using High Field and Ultra-High Field MRI

Validation and Optimization of Proximal Femurs Microstructure Analysis Using High Field and Ultra-High Field MRI

Detection of Relapse by Tumor Markers Versus Imaging in Children and Adolescents With Nongerminomatous Malignant Germ Cell Tumors: A Report From the Children’s Oncology Group

Assessment of Organ Dose by Direct and Indirect Measurements for a Wide Bore X-Ray Computed Tomography Unit That Used in Radiotherapy

Contact Info

Product

Resources

About