Abdominal radiotherapy is a cause for chronic pancreatitis

Risk of endocrine pancreatic insufficiency in patients receiving adjuvant chemoradiation for resected gastric cancer

“…Clinical signs and radiologic findings of chronic pancreatitis were reported years later after abdominal irradiation at doses ranging from 36-45 Gy [22][23][24]. The pancreatic tissue of these patients is normally functioning and exposed to radiation during abdominal irradiation for lymphoma and mimics the situation we are trying to investigate.…”

“…As a summary of these animal and human studies mentioned above [5][6][7][19][20][21][22][23][24][25][26], there is relative sensitivity of the exocrine part of the pancreas to irradiation in comparison to the endocrine part of the organ. Vascular damage is the most common cause of radiation toxicity [5][6][7][19][20][21][22][23][24][25][26].…”

“…Vascular damage is the most common cause of radiation toxicity [5][6][7][19][20][21][22][23][24][25][26]. The irradiated pancreatic tissue shrinks in size and becomes extremely fibrotic.…”

Endoskopische und perkutane Interventionen in der Langzeitbehandlung benigner Gallengangstenosen

“…Wir präsentieren hier den Fall eines Patienten mit benigner Gallengangstenose nach radiogener Therapie eines rechtsseitigen Nierenzellkarzinoms. Postradiogene DHC-und Duodenalstenosen sind seltene Ursachen benigner Gallenabflusshindernisse und können prinzipiell nach jeder Art von Bestrahlungstherapie auftreten, bei der eine räumliche Nähe zu Pankreas und Duodenum gegeben ist [6][7][8].…”

CFTR Gene Mutation in Patients with Apparently Idiopathic Pancreatitis: Lack of Phenotype-Genotype Correlation

“…All patients underwent CT scan and magnetic resonance imaging pancreatography (MRCP) or endoscopic ultrasonography (EUS). Excess alcohol intake (pure alcohol consumption ≥30 g/day for more than 2 years), biliary lithiasis (presence of gallbladder, common bile duct lithiasis or sludge) [17,18], hypercalcemia (>3 mmol/l) [19], hypertriglyceridemia (>10 mmol/l) [20], drugs/medication causing acute pancreatitis, personal history of abdominal radiotherapy [21], autoimmune disease (personal history of autoimmune disease, dosing of gammaglobulin, immunoglobulin A, G (including subfraction IgG4) and M, Latex Waaler-Rose, anti-nuclear antibodies, anti-smooth muscle antibodies, anti-mitochondrial antibodies, anti-neutrophil cytoplasmic antibodies) [22], traumatic pancreatitis and duct obstruction (mainly due to tumor) were ruled out in all patients. Besides the search for CF mutations, a hereditary cause of pancreatitis was systematically ruled out by questioning patients about family history and by searching for cationic trypsinogen gene mutations [14,16,23,24,25].…”