Abdominal Thrombotic and Ischemic Manifestations of the Antiphospholipid Antibody Syndrome: CT Findings in 42 Patients

Kaushik, Shaifali; Federle, Michael P.; Schur, Peter H.; Krishnan, Madhavan; Silverman, Stuart G.; Ros, Pablo R.

doi:10.1148/radiology.218.3.r01fe43768

Cited by 81 publications

(40 citation statements)

References 18 publications

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“…In our patient, a possible cause for rupture was hemolytic anemia (which caused enlargement of the spleen) or possible splenic thrombosis as demonstrated by the tomographic picture of the surrounding varicose veins. Similar to other thrombotic events, splenic thrombosis can be a manifestation of APLA syndrome, as shown in prior studies [2,13], making APLA syndrome a possible cause for splenic rupture.…”

Section: Discussionmentioning

confidence: 53%

Autoimmunity, preeclampsia and splenic rupture: a case report and literature review

Adler-Lazarovits

Mazor

Erez

2013

Case Reports in Perinatal Medicine

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Antiphospholipid antibody (APLA) syndrome is an autoimmune disease which is associated with preeclampsia and can cause thromboembolic events in several organs including the spleen. This report includes a case of post-partum splenic rupture in a woman with preeclampsia in the presence of APLA syndrome and a literature review of splenic rupture during the third trimester and puerperium. Unlike the prominent clinical manifestation of liver hematoma and rupture during preeclampsia, rupture of the spleen can be silent and mistakenly underdiagnosed.

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Section: Discussionmentioning

confidence: 53%

Autoimmunity, preeclampsia and splenic rupture: a case report and literature review

Adler-Lazarovits

Mazor

Erez

2013

Case Reports in Perinatal Medicine

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“…[5] In addition, liver infarction has also been reported in hepatocellular enzymes, the antiphospholipid antibody syndrome during pregnancy, in a hemodialysis patient with systemic lupus erythematosus, and in one additional non-pregnant patient. [6][7][8][9][10][11] One case of embolization from an atherosclerotic lesion has also been reported. [12] Although it seems like a logical conclusion, an etiological connection with thrombophilia -aside from the rare occurrence in antiphospholipid antibody syndrome -has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Liver infarction: To treat or not to treat?

Klein

Ackerman

et al. 2018

CRIM

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Liver infarctions are a very rare occurrence due to the multiple-source blood supply of the liver. The cause of hepatic infarction is unclear. When diagnosed, appropriate treatment of these infarctions is unknown. Herein we describe a case of acute liver infarctions, with no obvious cause, in a young woman. Work-up did not shed light on the underlying etiology. Treatment with anticoagulation was commenced in this case, with rapid improvement and a good clinical outcome. We suggest that anticoagulation can be administered to treat hepatic infarctions even in the absence of clear-cut thrombosis.

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“…Since melena, chest pain, backache, and urinary tract bleeding fluctuated in severity, they were suspected to be due to thrombosis in the respective tissues. 7,8 As for AVF occlusion, Golden and Belmont 10 have emphasized the importance of endothelial cell activation as a major component of thrombosis involving the microcirculation. They speculated that the "activated endothelial cells" provide and environment conducive to thrombotic occlusion.…”

Section: Discussionmentioning

confidence: 99%

Catastrophic antiphospholipid antibody syndrome following initiation of hemodialysis

et al. 2005

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Antiphospholipid syndrome (APS) is associated with arterial and venous thrombosis, pregnancy morbidity, and thrombocytopenia. Some APS patients develop rapid and disseminated microthrombosis and are known as having catastrophic APS or CAPS. We document here a case of CAPS in a patient who presented with various clinical symptoms and serious abnormalities of blood coagulation following initiation of hemodialysis after bilateral nephrectomy due to renal cancer. The patient developed multiple organ symptoms, including melena, visual disturbances, skin eruptions, lymph node swelling, urinary tract bleeding, backache, arteriovenous fistula occlusion, and chest pain. Based on the clinical course and serological and histological examinations, a diagnosis of CAPS was established. The patient recovered by following intensive anticoagulation and steroid therapy. Although CAPS is rare, once symptoms develop the condition deteriorates rapidly. Because of the associated high mortality, early diagnosis and prompt treatment are necessary.

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Abdominal Thrombotic and Ischemic Manifestations of the Antiphospholipid Antibody Syndrome: CT Findings in 42 Patients

Cited by 81 publications

References 18 publications

Autoimmunity, preeclampsia and splenic rupture: a case report and literature review

Autoimmunity, preeclampsia and splenic rupture: a case report and literature review

Liver infarction: To treat or not to treat?

Catastrophic antiphospholipid antibody syndrome following initiation of hemodialysis

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