Abdominal Wall Defects in Greenland 1989–2015

Bugge, Merete; Drachmann, Gitte; Kern, Peder; Budtz‐Jørgensen, Esben; Eiberg, Hans; Olsen, Britta; Tommerup, Niels; Nielsen, I. Møller

doi:10.1002/bdr2.1025

Cited by 16 publications

(18 citation statements)

References 20 publications

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“…Omphalocele prevalence estimates are roughly one-half those of gastroschisis, but the omphalocele prevalence may be underestimated due to the higher proportion of fetal deaths and terminations of omphalocele cases compared to gastroschisis (Akhtar et al, 2012;Brantberg et al, 2004;Kuleva et al, 2012;Perry et al, 2017;Springett et al, 2014). In addition, infants with omphalocele are more likely to be early preterm deliveries and have very low birth weights compared to infants with gastroschisis (Anderson et al, 2018;Bugge et al, 2017;Feldkamp et al, 2016;Marshall et al, 2015). Despite the increase in prevalence of gastroschisis that has been well-documented in the literature, it is clear that omphalocele also presents a large burden for families and the healthcare system.…”

Section: Discussionmentioning

confidence: 99%

“…Gastroschisis is one of the few major birth defects with a documented increasing birth prevalence in both resource-limited and resource-rich settings. In fact, the prevalence of gastroschisis has been increasing worldwide for decades (Bugge et al, 2017;Castilla, Mastroiacovo, & Orioli, 2008;Kazaura et al, 2004;Loane, Dolk, Bradbury, & Group, 2007;Whitehall, Kandasamy, Stalewski, & Gill, 2010) as well as in the United States (B. G. Benjamin, Ethen, Van Hook, Myers, & Canfield, 2010;Chabra, Gleason, Seidel, & Williams, 2011;Collins et al, 2007;Hougland, Hanna, Meyers, & Null, 2005;Jones et al, 2016;Kirby et al, 2013;Laughon et al, 2003;Salemi et al, 2009;Salihu, Pierre-Louis, Druschel, & Kirby, 2003;Short et al, 2019;St Louis et al, 2017;Vo & Langlois, 2015;Vu et al, 2008). Reasons for the increasing prevalence in gastroschisis are unknown; however, several risk factors are associated with this defect, especially young maternal age.…”

Section: Gastroschisismentioning

confidence: 99%

“…The estimated prevalence of omphalocele ranges from 1.0 per 10,000 live births (St Louis et al, 2017) to 3.8 per 10,000 live births (Springett et al, 2014). In contrast to gastroschisis, prevalence studies of omphalocele have reported either stable rates (Allman et al, 2016;Bugge et al, 2017;Marshall et al, 2015) or modest increases over time (St Louis et al, 2017). Other studies have reported inconsistent results regarding maternal age (Agopian, Marengo, & Mitchell, 2009;Goldkrand, Causey, & Hull, 2004;Marshall et al, 2015;St Louis et al, 2017).…”

Section: Omphalocelementioning

confidence: 99%

“…Similarly, Benjamin and Wilson (2014) reported that roughly 80% of cases of omphalocele had an associated anomaly. Defects that occur with omphalocele primarily include those of the cardiovascular system, musculoskeletal system, gastrointestinal system, urogenital system, and central nervous system as well as chromosomal defects (Benjamin & Wilson, 2014;Bugge et al, 2017;Springett et al, 2014;Stoll et al, 2008). Approximately one-sixth of omphalocele cases also have chromosomal anomalies, which are more common in infants born to women aged 35 years and older and among male infants (Marshall et al, 2015).…”

Section: Omphalocelementioning

confidence: 99%

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Population‐based birth defects data in the United States, 2012–2016: A focus on abdominal wall defects

Stallings

Isenburg

Short

et al. 2019

Birth Defects Research

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Background/Objectives: In this report, the National Birth Defects Prevention Network (NBDPN) examines and compares gastroschisis and omphalocele for a recent 5-year birth cohort using data from 30 population-based birth defect surveillance programs in the United States. Methods: As a special call for data for the 2019 NBDPN Annual Report, state programs reported expanded data on gastroschisis and omphalocele for birth years 2012–2016. We estimated the overall prevalence (per 10,000 live births) and 95% confidence intervals (CI) for each defect as well as by maternal race/ethnicity, maternal age, infant sex, and case ascertainment methodology utilized by the program (active vs. passive). We also compared distribution of cases by maternal and infant factors and presence/absence of other birth defects. Results: The overall prevalence estimates (per 10,000 live births) were 4.3 (95% CI:4.1–4.4) for gastroschisis and 2.1 (95% CI: 2.0–2.2) for omphalocele. Gastroschisis was more frequent among young mothers (<25 years) and omphalocele more common among older mothers (>40 years). Mothers of infants with gastroschisis were more likely to be underweight/normal weight prior to pregnancy and mothers of infants with omphalocele more likely to be overweight/obese. Omphalocele was twice as likely as gastroschisis to co-occur with other birth defects. Conclusions: This report highlights important differences between gastroschisis and omphalocele. These differences indicate the importance of distinguishing between these defects in epidemiologic assessments. The report also provides additional data on co-occurrence of gastroschisis and omphalocele with other birth defects. This information can provide a basis for future research to better understand these defects.

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Section: Discussionmentioning

confidence: 99%

Section: Gastroschisismentioning

confidence: 99%

Section: Omphalocelementioning

confidence: 99%

Section: Omphalocelementioning

confidence: 99%

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Population‐based birth defects data in the United States, 2012–2016: A focus on abdominal wall defects

Stallings

Isenburg

Short

et al. 2019

Birth Defects Research

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“…If this is the mechanism that results in gastroschisis, the critical timing of an exposure may involve several months: before or after conception, or, before, during or after the merging of the body stalk and omphalomesenteric stalk (21–35 days postconception) 2. The prevalence of gastroschisis in recent decades shows a remarkable and worrying increasing trend in the USA3–6 and elsewhere,7 8 suggesting a role of an environmental factor yet unknown. Most infants with gastroschisis (approximately 80% in several studies)6 7 9 are born to women under 25 years of age, and rates are highest among infants born to the youngest mothers (<20 years of age), for reasons that are unclear.…”

Section: Introductionmentioning

confidence: 99%

Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997–2011

et al. 2019

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ObjectiveTo assess the association between occurrence and timing of maternal self-reported genitourinary tract infection (urinary tract infections [UTIs] and/or sexually transmitted infection [STI]) and risk for gastroschisis in the offspring.DesignPopulation-based case–control study.SettingNational Birth Defects Prevention Study, a multisite study in the USA.ParticipantsMothers of 1366 gastroschisis cases and 11 238 healthy controls.Main outcome measuresCrude and adjusted ORs (aORs) with 95% CIs.ResultsGenitourinary infections were frequent in case (19.3%) and control women (9.9%) during the periconceptional period (defined as 3 months prior to 3 months after conception). UTI and/or STI in the periconceptional period were associated with similarly increased risks for gastroschisis (aOR 1.5, 95% CI 1.3 to 1.8; aOR 1.6, 95% CI 1.2 to 2.3, respectively). The risk was increased with a UTI before (aOR 2.5; 95% CI 1.4 to 4.5) or after (aOR 1.7; 95% CI 1.1 to 2.6) conception only among women ≥25 years of age. The risk was highest among women <20 years of age with an STI before conception (aOR 3.6; 95% CI 1.5 to 8.4) and in women ≥25 years of age, the risk was similar for before (aOR 2.9; 95% CI 1.0 to 8.5) and after (aOR 2.8; 95% CI 1.3 to 6.1) conception. A specific STI pathogen was reported in 89.3% (50/56) of cases and 84.3% (162/191) of controls withChlamydia trachomatisthe most common (25/50 cases, 50%; 58/162 controls, 36%) and highest among women <20 years of age (16/25 cases, 64%; 22/33 controls, 67%).ConclusionsUTI and/or STI were associated with an increased risk for gastroschisis, with the strength of the association varying by maternal age and timing of infection.

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Prevalence rates study of selected isolatednon‐Mendeliancongenital anomalies in the Hutterite population of Alberta, 1980–2016

Lowry

Bedard

Crawford

et al. 2020

American J of Med Genetics Pt A

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A study of the prevalence rates for selected isolated non-Mendelian congenital anomalies in the Hutterite Brethren of Alberta, Canada was undertaken to further examine longitudinal data in this isolated community that was last reported in 1985 (Lowry et al., 1985), although there are numerous publications on recessive disorders (Boycott et al., 2008; Triggs-Raine et al., 2016). Cases were ascertained from the Alberta Congenital Anomaly Surveillance System for the years 1997-2016. Since our initial results showed some surprising findings in the Hutterite Brethren, such as zero cases of spina bifida, cleft lip and palate, gastroschisis, and omphalocele, and a significant excess of cases with hypospadias, we extended the study to prior years (1980-1996) for selected anomalies. For the extended study period (1980-2016), there was a significant increased prevalence of hypospadias, tetralogy of Fallot and tricuspid atresia in the Hutterite population, and although not statistically significant, zero cases of cleft lip with cleft palate, gastroschisis and omphalocele were confirmed. Further research is needed to determine the precise effects of rural environmental exposures, lifestyle factors, and genetic associations for selected multifactorial congenital anomalies.

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Abdominal Wall Defects in Greenland 1989–2015

Cited by 16 publications

References 20 publications

Population‐based birth defects data in the United States, 2012–2016: A focus on abdominal wall defects

Population‐based birth defects data in the United States, 2012–2016: A focus on abdominal wall defects

Risk of gastroschisis with maternal genitourinary infections: the US National birth defects prevention study 1997–2011

Prevalence rates study of selected isolatednon‐Mendeliancongenital anomalies in the Hutterite population of Alberta, 1980–2016

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