Abdominal Wall Hernia Repair: A Comparison of Sepramesh and Parietex Composite Mesh in a Rabbit Hernia Model

Judge, Timothy; Parker, David M.; Dinsmore, Robert C.

doi:10.1016/j.jamcollsurg.2006.11.003

Cited by 60 publications

(37 citation statements)

References 14 publications

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“…Prolonged presence of active fibroblasts then might induce more tenacious adhesions, as observed. 14,26 Overall, the results of the microscopic analyses (histology) and the macroscopic adhesion scores were consistent.…”

Section: Discussion and Concluding Remarksmentioning

confidence: 61%

“…12,24,26 These complications may have serious consequences, such as chronic pain, recurrence of the hernia or even intestinal obstruction and enterocutaneous fistulas. 14,26 A review of the literature on the use of polymer meshes for incisional hernia repair learned that studies of biomaterial-tissue interactions have hardly played a role in the development of these implants. The majority of the commercial meshes are made out of knitted polypropylene (PP) fibers (e.g., Prolene Ò , Marlex Ò , Trelex Ò ).…”

Section: Introductionmentioning

confidence: 99%

“…Others have more or less successfully used different coatings from a biological origin such as sodium hyaluronate/ carboxymethylcellulose 10,26 or an absorbable layer of oxidized regenerated cellulose. 14,15,26 Of course, it remains to be established whether or not these coatings are capable of adhesion prevention in the long term. In view of the fact that biological coatings are susceptible to hydrolytic or enzymatic degradation, it must be expected that these coatings will not provide long-term non-adhesiveness.…”

Section: Introductionmentioning

confidence: 99%

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Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

et al. 2008

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Abstract-Abdominal surgery is associated with a significant risk for incisional herniation. Hernia repair is routinely performed by implantation of synthetic meshes. Such meshes may cause serious adhesions between the implanted material and organs leading to intestinal obstruction or enterocutaneous fistulas. This study compares three knitted meshes for their capacity to prevent adhesion formation in an in vivo study. The meshes evaluated are polypropylene (Prolene Ò ), polypropylene coated with oxygenated regenerated cellulose-in principle-a biodegradable biomaterial (Proceed Ò ), and Prolene Ò coated with a nondegradable copolymer of the hydrophilic building block N-vinyl pyrrolidone (NVP) and the hydrophobic building block n-butylmethacrylate (BMA). The meshes were implanted in the abdomen of rats (followup 7 or 30 days). After 7 days, the formation of adhesions decreased in the order: Prolene Ò > NVP/BMA-coated Prolene Ò > Proceed Ò ; after 30 days, this order changed into: Proceed Ò > Prolene Ò > NVP/BMA-coated Prolene Ò . Both at 7 and at 30 days, Proceed Ò was the only mesh surrounded by macrophage cells that contained foreign materials, presumably degradation products of the (biodegradable) surface coating. The data indicate that long-term protection of implanted meshes against excessive adhesions may be achieved through stable biocompatible hydrogel surface coatings.

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Section: Discussion and Concluding Remarksmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

et al. 2008

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“…These infiltrating fibroblasts demonstrated a longitudinal directional alignment in parallel to the abdominal wall. Further, none of the biomaterials induced severe bowel adhesions, which are commonly seen when synthetic biomaterials are used [45][46][47][48]. The adhesions seen in this study were limited mainly to the suture material used (Prolene, non absorbable) [49].…”

Section: Discussionmentioning

confidence: 97%

One and four layer acellular bladder matrix for fascial tissue reconstruction

Eberli

Atala

Yoo

2011

J Mater Sci: Mater Med

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To determine whether the use of multiple layers of acellular bladder matrix (ABM) is more suitable for the treatment of abdominal wall hernia than a single layered ABM. The feasibility, biocompatibility and mechanical properties of both materials were assessed and compared. Biocompatibility testing was performed on 4 and 1 layered ABM. The matrices were used to repair an abdominal hernia model in 24 rabbits. The animals were followed for up to 3 months. Immediately after euthanasia, the implant site was inspected and samples were retrieved for histology, scanning electron microscopy and biomechanical studies. Both acellular biomaterials demonstrated excellent biocompatibility. At the time of retrieval, there was no evidence of infection. The matrices demonstrated biomechanical properties comparable to native tissue. Three hernias (25%) were found in the single layer ABM group and only 1 hernia (8%) was found in the 4 layer ABM group. Histologically, the matrix structure was intact and the cell density within the matrices decreased with time. The dominant cell type present within the matrices shifted from lymphocytes to fibroblasts over time. Both ABMs maintained adequate strength over time when used for hernia repair, and there was an extremely low incidence of adhesion formation. The single layer ABM showed enhanced cellular integration, while the 4 layer ABM reduced hernia formation. Either of these matrices may be useful as an off-the-shelf biomaterial for patients requiring fascial repair. TITLE:ONE To determine whether the use of multiple layers of acellular bladder matrix (ABM) is more suitable for the treatment of abdominal wall hernia than a single layered ABM. The feasibility, biocompatibility and mechanical properties of both materials were assessed and compared.Design and Method: Biocompatibility testing was performed on 4 and 1 layered ABM.The matrices were used to repair an abdominal hernia model in 24 rabbits. The animals were followed for up to 3 months. Immediately after euthanasia, the implant site was inspected and samples were retrieved for histology, scanning electron microscopy and biomechanical studies.Results: Both acellular biomaterials demonstrated excellent biocompatibility. At the time of retrieval, there was no evidence of infection. The matrices demonstrated biomechanical properties comparable to native tissue. Three hernias (25%) were found in the single layer ABM group and only 1 hernia (8%) was found in the 4 layer ABM group.Histologically, the matrix structure was intact and the cell density within the matrices decreased with time. The dominant cell type present within the matrices shifted from lymphocytes to fibroblasts over time.

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“…The consensus or a reliable algorithm to hernia treatment remains a challenge [1][2][3][4][5] . In the same way, the reports using animals have limiting points like the use of different species, mainly rats [6][7][8] , rabbits [9][10][11] and pigs [12][13][14] , and different procedures to promote the model of hernia to be used for the further technique and/or mesh reinforce. Most of them make an acute defect by provoking a hole on the abdominal wall, which is immediately repaired.…”

Section: Introductionmentioning

confidence: 99%

Animal model of chronic abdominal hernia in rabbit

Silva

Fagundes

Seidel³

et al. 2009

Acta Cir. Bras.

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Purpose: To create a feasible animal model of hernia that should be reliable to test the different types of mesh and/or surgical technique. Methods: Thirty six male New Zealand albino rabbits were submitted to surgical procedure to provoke a standard hole in the abdominal wall. A metallic frame measuring 3 cm length and 1 cm width was allocated longitudinally on the umbilicus scar and the comprehensive three squared centimeters area was resected. A continuous 4.0 polyamide was performed to closure the subcutaneous and skin. Results: During three weeks a score of signals/symptoms was performed to evaluate the wound and clinical conditions. No death or severe complications occurred. In the 3rd week the hernia ring and visceral adhesions were evaluated. Soft omental adherences were present in the hernial sac in all animals. The area of hernia ring ranged from 32.1±5.5 to 35.6±3.1 squared centimeter and the maximum was 39 cm 2 and the minimum was 30 cm 2 . The model results in protrusion which was similar to a human incisional hernia with hernia sac, visceral adhesions and fibrous healing ring. Conclusion: The model was more reliable to test further techniques or mesh on hernia repair. Key words: Hernia, Ventral. Hernia, Abdominal. Wound Healing. Animal Experimentation. Rabbits. RESUMO Objetivo:Criação de um modelo animal de hérnia que seja confiável para testar as diferentes técnicas e tipos de telas. Métodos: Trinta e seis coelhos foram submetidos a procedimento operatório que provocou uma falha na parede abdominal. Uma moldura metálica com 3 cm de comprimento e 1 cm de largura foi colocada longitudinalmente sobre a cicatriz umbilical e ressecada uma área de 3cm 2 . Uma sutura contínua de poliamida 4.0 fechou a tela subcutânea e pele. Resultados: durante três semanas o escore de sinais e sintomas foi coletado para avaliar as condições clínicas e da ferida operatória. Não ocorreram óbitos ou complicações graves. Na terceira semana o anel herniário e aderências peritoneais foram avaliadas. Aderências frouxas estavam presentes no saco herniário em todos os animais. A área do anel herniário variou de 32.1±5.5 a 35.6±3.1 cm 2 , com um máximo de 39 cm 2 e um mínimo de 30 cm 2 . O modelo resultou numa protrusão de vísceras semelhante ao que ocorre em hérnia incisional de humanos. Conclusão: O modelo é factível para testar técnicas operatórias ou telas na reconstrução de hérnias incisionais.

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Abdominal Wall Hernia Repair: A Comparison of Sepramesh and Parietex Composite Mesh in a Rabbit Hernia Model

Cited by 60 publications

References 14 publications

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

Polypropylene Meshes to Prevent Abdominal Herniation. Can Stable Coatings Prevent Adhesions in the Long Term?

One and four layer acellular bladder matrix for fascial tissue reconstruction

Animal model of chronic abdominal hernia in rabbit

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