Aberrant axillary breast tissue: A report of a family with six affected women in two generations

Abstract

A family with bilateral accessory axillary breasts without nipples or areolae in six adult females of two generations is reported. The anomaly is most likely caused by an auto-soma1 dominant gene of variable expressivity which prevents normal regression of the embryonal mammary ridge. Accessory breasts with and without nipples and areolae have been seen in another family in the literature. In the absence of areolae or nipples the trait will usually be undetectable in prepubertal females and in males of all ages.

Fibroadenoma of the Axilla

“…However, it is suspected that it may also be a hereditary condition. Viera and Weinberg and Motulsky reported familial cases 5,6 . This may be explained by hereditary autosomal dominant genes with variable expression that inhibit the normal regression of the embryonic mammary ridge.…”

"Supernumerary Breast: About an Uncommon Case Report"

“…Any abnormality in the involution of the mammary Crete results in the persistence of glandular tissue anywhere along the lacteal line, from the axilla to the inguinal region, which can lead to the appearance of other buds whose persistence results in accessory or supernumerary breasts or polymastia [2]. Familial cases have been reported [3] and there is a hypothesis of autosomal dominant genetic transmission [4]. In our observation, no family antecedent had been found.…”

Untitled

“…Any abnormality in the involution of the mammary Crete results in the persistence of glandular tissue anywhere along the lacteal line, from the axilla to the inguinal region, which can lead to the appearance of other buds whose persistence results in accessory or supernumerary breasts or polymastia [2]. Familial cases have been reported [3] and there is a hypothesis of autosomal dominant genetic transmission [4]. In our observation, no family antecedent had been found.…”