Aberrant B-cell Subsets and Immunoglobulin Levels in Patients with Moderate-to-severe Psoriasis

Kahlert, Katrin; Grän, Franziska; Muhammad, Khalid; Benoit, Sandrine; Serfling, Edgar; Goebeler, Matthias; Kerstan, Andreas

doi:10.2340/00015555-3069

Cited by 12 publications

(4 citation statements)

References 14 publications

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“…Previous investigations indicate an elevation of transitional B-cells in the peripheral blood of psoriasis patients compared to normal subjects, potentially as a compensatory mechanism triggered by inflammation [ 51 – 53 ]. Nevertheless, our data unveils a synchronization of immune cell communication in psoriasis, activating B-cells into an input signaling pattern that synergistically reinforces T-cell input signaling.…”

Section: Discussionmentioning

confidence: 99%

Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

Xiong,

Li,

Bai

et al. 2024

Aging

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Psoriasis, a complex and recurrent chronic inflammatory skin disease involving various inflammatory cell types, requires effective cell communication to maintain the homeostatic balance of inflammation. However, patterns of communication at the single-cell level have not been systematically investigated. In this study, we employed social network analysis tools, pattern recognition, and manifold learning to compare molecular communication features between psoriasis cells and normal skin cells. Utilizing a process that facilitates the discovery of cell type-specific regulons, we analyzed internal regulatory networks among different cells in psoriasis. Advanced techniques for the quantitative detection of non-targeted proteins in pathological tissue sections were employed to demonstrate protein expression. Our findings revealed a synergistic interplay among the communication signals of immune cells in psoriasis. B-cells were activated, while Langerhans cells shifted into the primary signaling output mode to fulfill antigen presentation, mediating T-cell immunity. In contrast to normal skin cells, psoriasis cells shut down numerous signaling pathways, influencing the balance of skin cell renewal and differentiation. Additionally, we identified a significant number of active cell type-specific regulons of resident immune cells around the hair follicle. This study unveiled the molecular communication features of the hair follicle cell-psoriasis axis, showcasing its potential for therapeutic targeting at the single-cell level. By elucidating the pattern of immune cell communication in psoriasis and identifying new molecular features of the hair follicle cell-psoriasis axis, our findings present innovative strategies for drug targeting to enhance psoriasis treatment.

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Section: Discussionmentioning

confidence: 99%

Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

Xiong,

Li,

Bai

et al. 2024

Aging

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show abstract

“…B cells have an important role in the protection against different infectious and inflammatory diseases, but there are very few reports on B lymphocytes involvement in Ps. The regulatory sub-population of B cells, B regs were found decreased in Ps patients [ 61 ] and moreover, it was shown that B regs may positively influence the course of Ps by producing IL-10 [ 62 , 63 ]. Therefore, the B cells increase that we have noticed in the treated group could account for the clinical improvement of the induced Ps.…”

Section: Discussionmentioning

confidence: 99%

Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome

Surcel

Munteanu

Isvoranu

et al. 2021

JPM

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Psoriasis has a multifactorial pathogenesis and recently it was shown that alterations in the skin and intestinal microbiome are involved in the pathogenesis of psoriasis. Therefore, microbiome restoration becomes a promising preventive/therapy strategy in psoriasis. In our pre-clinical study design using a mice model of induced psoriatic dermatitis (Ps) we have tested the proof-of-concept that IgY raised against pathological human bacteria resistant to antibiotics can alleviate psoriatic lesions and restore deregulated immune cell parameters. Besides clinical evaluation of the mice and histology of the developed psoriatic lesions, cellular immune parameters were monitored. Immune cells populations/subpopulations from peripheral blood and spleen cell suspensions that follow the clinical improvement were assessed using flow cytometry. We have quantified T lymphocytes (CD3ε+) with T-helper (CD4+CD8−) and T-suppressor/cytotoxic (CD8a+CD4−) subsets, B lymphocytes (CD3ε−CD19+) and NK cells (CD3ε−NK1.1+). Improved clinical evolution of the induced Ps along with the restoration of immune cells parameters were obtained when orally IgY was administered. We pin-point that IgY specific compound can be used as a possible pre-biotic-like alternative adjuvant in psoriasis.

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“…Skin-resident B cells have been found to produce various inflammatory cytokines such as IL-4, IL-6, GM-CSF, and IFN-γ, which could enhance the inflammatory response seen in Ps (Shen and Fillatreau 2015;Grän et al 2020). Interestingly, studies have reported reduced numbers of regulatory B cells (Bregs) in both the blood and skin of Ps patients compared to healthy individuals (Hayashi et al 2016;Lu et al 2016;Mavropoulos et al 2017;Kahlert et al 2019). Notably, the levels of IL-10 + B cells were decreased and were inversely correlated with the presence of IL-17A + and IFN-γ + T cells and with the severity of the disease (Hayashi et al 2016;Mavropoulos et al 2017).…”

Section: Immune Cell Fate With Respect To Autophagy and Lysosomal Adm...mentioning

confidence: 99%

Insights into Autophagic Machinery and Lysosomal Function in Cells Involved in the Psoriatic Immune-Mediated Inflammatory Cascade

Kuczyńska,

Moskot,

Gabig-Cimińska

2024

Archivum Immunologiae Et Therapiae Experimentalis

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Impaired autophagy, due to the dysfunction of lysosomal organelles, contributes to maladaptive responses by pathways central to the immune system. Deciphering the immune–inflammatory ecosystem is essential, but remains a major challenge in terms of understanding the mechanisms responsible for autoimmune diseases. Accumulating evidence implicates a role that is played by a dysfunctional autophagy–lysosomal pathway (ALP) and an immune niche in psoriasis (Ps), one of the most common chronic skin diseases, characterized by the co-existence of autoimmune and autoinflammatory responses. The dysregulated autophagy associated with the defective lysosomal system is only one aspect of Ps pathogenesis. It probably cannot fully explain the pathomechanism involved in Ps, but it is likely important and should be seriously considered in Ps research. This review provides a recent update on discoveries in the field. Also, it sheds light on how the dysregulation of intracellular pathways, coming from modulated autophagy and endolysosomal trafficking, characteristic of key players of the disease, i.e., skin-resident cells, as well as circulating immune cells, may be responsible for immune impairment and the development of Ps.

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Aberrant B-cell Subsets and Immunoglobulin Levels in Patients with Moderate-to-severe Psoriasis

Cited by 12 publications

References 14 publications

Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

Generating detailed intercellular communication patterns in psoriasis at the single-cell level using social networking, pattern recognition, and manifold learning methods to optimize treatment strategies

Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome

Insights into Autophagic Machinery and Lysosomal Function in Cells Involved in the Psoriatic Immune-Mediated Inflammatory Cascade

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