2024
DOI: 10.3389/fimmu.2024.1368572
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Aberrant CD8+T cells drive reproductive dysfunction in female mice with elevated IFN-γ levels

Enitome E. Bafor,
Rebecca A. Erwin-Cohen,
Toni Martin
et al.

Abstract: IntroductionInterferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or chronic inflammatory conditions, is implicated in adverse reproductive outcomes such as pregnancy failure or infertility. Additionally, the underlying immunological mechanisms remain elusive.MethodsHere, we explore the impact of systemic IFN-γ elevation on cytotoxic T cell responses in female reproduction utilizing a systemic lupus-pro… Show more

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