Aberrant Coupling Within and Across the Default Mode, Task-Positive, and Salience Network in Subjects at Risk for Psychosis

Wotruba, Diana; Michels, Lars; Buechler, Roman; Metzler, Sibylle; Theodoridou, Anastasia; Gerstenberg, Miriam; Walitza, Susanne; Kollias, Spyros; Rössler, Wulf; Heekeren, Karsten

doi:10.1093/schbul/sbt161

Cited by 158 publications

(135 citation statements)

References 69 publications

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“…Notably, a negative association was found between the correlation of default mode network and the task-positive network and the expression of cognitive impairments. 40 Importantly, the reduced insula-ACC connectivity was evident only in untreated, not antipsychotic-treated, patients with FEP, suggesting a normalization of this functional coupling via …”

Section: Discussionmentioning

confidence: 97%

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

Schmidt

Palaniyappan

Smieskova

et al. 2016

jpn

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IntroductionOur brain is constantly exposed to a wide variety of stimuli, which compete for limited cognitive resources. External stimu li are processed depending on their salience so as to ignore predictable, state and task-irrelevant events while enhancing resource allocation in order to process unexpected or state-and task-relevant events. Efficient prediction of salient stimuli, such as those of rewards, is thus essential for adapting ongoing behaviour. This process requires the ability to learn that a neutral stimulus becomes emotionally endowed owing to its association with primary reinforcement. 1 Behavioural and fMRI studies have demonstrated impairments in patients with psychosis when anticipating reward.2 Relative to controls, behavioural evidence indicated that patients with rst-episode psychosis (FEP) exhibited less reactivity to reward-predicting cues.3 Functional MRI studies during reward prediction have reported reduced activity in diverse brain regions, including the ventral striatum (VS), 4,5 anterior cingulate cortex (ACC), midbrain, thalamus and cerebellum, of unmedicated patients with FEP compared with controls. 5 It has further been shown that VS activation during reward prediction was negatively related to positive psychotic symptoms in patients with FEP. 4,5 Reward processing is critically mediated by dopamine, 6,7 and the VS response to reward-predicting cues is likely triggered by dopamine activity. 8,9 A previous fMRI study in patients with chronic schizophrenia showed that the VS response during reward prediction was reduced only in patients treated with typical antipsychotics, whereas no difference was observed between healthy controls and patients treated with atypical medication. 10 In line with this nding in patients with chronic schizophrenia, the reduced baseline VS activation during reward prediction seen in patients with FEP relative to healthy controls has been reported to be normalized after 6 weeks of monotherapy with atypical antipsychotics.11 The largest improvement in positive symptoms was seen in patients with the highest VS signal increase.11 Although not speci cally during reward processing, a recent resting-state fMRI study in patients Background: Increasing evidence indicates that psychosis is associated with abnormal reward processing. Imaging studies in patients with first-episode psychosis (FEP) have revealed reduced activity in diverse brain regions, including the ventral striatum, insula and anterior cingulate cortex (ACC), during reward prediction. However, whether these reductions in local brain activity are due to altered connectivity has rarely been explored. Methods: We applied dynamic causal modelling and Bayesian model selection to fMRI data during the Salience Attribution Task to investigate whether patients with FEP showed abnormal modulation of connectivity between the ventral striatum, insula and ACC induced by rewarding cues and whether these changes were related to positive psychotic symptoms and atypical antipsychotic medication. Results: The model...

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Section: Discussionmentioning

confidence: 97%

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

Schmidt

Palaniyappan

Smieskova

et al. 2016

jpn

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“…57 Similarly, individuals at risk for psychosis demonstrated a positive correlation between the medial prefrontal cortex (associated with the DMN) and the right dorsolateral prefrontal cortex (associated with the CEN). 63 The positive relationship between activity in the DMN and the CEN can lead to difficulty separating internally vs externally generated stimuli. Therefore, the relationship between the DMN and the CEN might be linked to the misattribution of agency in patients.…”

Section: Soa Schizophrenia and The Resting Statementioning

confidence: 99%

Is the Sense of Agency in Schizophrenia Influenced by Resting-State Variation in Self-Referential Regions of the Brain?

Robinson

Wagner

Northoff³

2015

SCHBUL

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Schizophrenia is a disturbance of the self, of which the attribution of agency is a major component. In this article, we review current theories of the Sense of Agency, their relevance to schizophrenia, and propose a novel framework for future research. We explore some of the models of agency, in which both bottom-up and top-down processes are implicated in the genesis of agency. We further this line of inquiry by suggesting that ongoing neurological activity (the brain's resting state) in self-referential regions of the brain can provide a deeper level of influence beyond what the current models capture. Based on neuroimaging studies, we suggest that aberrant activity in regions such as the default mode network of individuals with schizophrenia can lead to a misattribution of internally/externally generated stimuli. This can result in symptoms such as thought insertion and delusions of control. Consequently, neuroimaging can contribute to a more comprehensive conceptualization and measurement of agency and potential treatment implications.

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“…From this perspective schizophrenia has been associated with changes in functional connectivity [68] and homogeneity of the midline cortex [69], an anterior-to-posterior shift during self-reflection [70], as well as aberrant coupling within and across the default mode network and other brain networks [71]. Moreover, the PCC (posterior cingulate cortex) which is a crucial node of the default mode network [72] is commonly implicated in schizophrenia [73,74].…”

Section: The Self Schizophrenia and Brain Midline Regionsmentioning

confidence: 99%

Psychopathology of the Bodily Self and the Brain: The Case of Schizophrenia

Gallese

Ferri

2014

Psychopathology

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In the present paper, we review the recent empirical evidence on the neurobiological basis of a minimal notion of the self, the bodily self. We show the relationship between the body, its motor potentialities and the notion of minimal self. We argue that this approach can shed new light onto self-disturbances and social deficits characterizing schizophrenia. We discuss our approach with other views on the neural correlates of self-disturbances in schizophrenia and propose that cognitive neuroscience can today address the classical topics of psychopathology by adding a new level of description, finally enabling the correlation between the first-person experiential aspects of psychiatric diseases and their neurobiological roots.

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Aberrant Coupling Within and Across the Default Mode, Task-Positive, and Salience Network in Subjects at Risk for Psychosis

Cited by 158 publications

References 69 publications

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis

Is the Sense of Agency in Schizophrenia Influenced by Resting-State Variation in Self-Referential Regions of the Brain?

Psychopathology of the Bodily Self and the Brain: The Case of Schizophrenia

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