Aberrant DNA Methylation in Cutaneous Squamous Cell Carcinoma

Li, Fengjuan; Wu, Yi; Lv, Qun; Yang, Xueyuan; Jiang, Mingjun; Li, Liming

doi:10.1097/jd9.0000000000000054

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…Additionally, cSCCs exhibit a high tumor mutational burden (TMB), particularly with UV signature mutations, which leads to loss of function in tumor suppressor genes or gain of function in proto-oncogenes [11,12]. Epigenetic changes in methylation patterns [13] or alterations in miRNA expression in cutaneous SCCs [14] are important additional effectors in cSCC etiology, alongside genetic factors. Understanding the changes in miRNA expression during cSCC development and progression is of particular interest, as miRNAs can be used as biomarkers (liquid biopsies) in body fluids to monitor pathological processes or therapies longitudinally.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of Simulated-Solar-Radiation-Sensitive miR-205-5p Does Not Induce Progression of Cutaneous Squamous Cell Carcinoma In Vitro

Bender,

Chen,

Henning

et al. 2023

IJMS

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Solar radiation is the main risk factor for cSCC development, yet it is unclear whether the progression of cSCC is promoted by solar radiation in the same way as initial tumorigenesis. Additionally, the role of miRNAs, which exert crucial functions in various tumors, needs to be further elucidated in the context of cSCC progression and connection to solar radiation. Thus, we chronically irradiated five cSCC cell lines (Met-1, Met-4, SCC-12, SCC-13, SCL-II) with a custom-built irradiation device mimicking the solar spectrum (UVB, UVA, visible light (VIS), and near-infrared (IRA)). Subsequently, miRNA expression of 51 cancer-associated miRNAs was scrutinized using a flow cytometric multiplex quantification assay (FirePlex®, Abcam). In total, nine miRNAs were differentially expressed in cell-type-specific as well as universal manners. miR-205-5p was the only miRNA downregulated after SSR-irradiation in agreement with previously gathered data in tissue samples. However, inhibition of miR-205-5p with an antagomir did not affect cell cycle, cell growth, apoptosis, or migration in vitro despite transient upregulation of oncogenic target genes after miR-205-5p knockdown. These results render miR-205-5p an unlikely intracellular effector in cSCC progression. Thus, effects on intercellular communication in cSCC or the simultaneous examination of complementary miRNA sets should be investigated.

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Section: Introductionmentioning

confidence: 99%

Knockdown of Simulated-Solar-Radiation-Sensitive miR-205-5p Does Not Induce Progression of Cutaneous Squamous Cell Carcinoma In Vitro

Bender,

Chen,

Henning

et al. 2023

IJMS

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“…These epigenetic mechanisms are connected, occurring in concert with other molecular processes/factors inducing chromatin architecture modifications, ultimately leading to gene regulation [ 11 ]. Alterations in HPTMs, DNA methylation, and miRNA expression, result in instable cell states; gene expression changes; and, eventually, carcinogenesis [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma

Rotondo

Mazziotta

Lanzillotti

et al. 2021

IJMS

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Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and microRNA (miRNA) regulation on MCPyV-driven MCC has recently been highlighted. In this review, we aim to describe and discuss the latest insights into HPTMs, DNA methylation, and miRNA regulation, as well as their regulative factors in the context of MCPyV-driven MCC, to provide an overview of current findings on how MCPyV is involved in the dysregulation of these epigenetic processes. The current state of the art is also described as far as potentially using epigenetic dysregulations and related factors as diagnostic and prognostic tools is concerned, in addition to targets for MCPyV-driven MCC therapy. Growing evidence suggests that the dysregulation of HPTMs, DNA methylation, and miRNA pathways plays a role in MCPyV-driven MCC etiopathogenesis, which, therefore, may potentially be clinically significant for this deadly tumor. A deeper understanding of these mechanisms and related factors may improve diagnosis, prognosis, and therapy for MCPyV-driven MCC.

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5-Aminolevulinic Acid Photodynamic Therapy combined with CO2 laser therapy in treatment of laryngeal papilloma: Case report

Zhang

Yang

Zou

et al. 2016

Photodiagnosis and Photodynamic Therapy

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Aberrant DNA Methylation in Cutaneous Squamous Cell Carcinoma

Cited by 3 publications

References 67 publications

Knockdown of Simulated-Solar-Radiation-Sensitive miR-205-5p Does Not Induce Progression of Cutaneous Squamous Cell Carcinoma In Vitro

Knockdown of Simulated-Solar-Radiation-Sensitive miR-205-5p Does Not Induce Progression of Cutaneous Squamous Cell Carcinoma In Vitro

Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma

5-Aminolevulinic Acid Photodynamic Therapy combined with CO2 laser therapy in treatment of laryngeal papilloma: Case report

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