2007
DOI: 10.1093/hmg/ddm187
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Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients

Abstract: Recent studies suggest that assisted reproductive technologies (ART), which involve the isolation, handling and culture of gametes and early embryos, are associated with an increased incidence of rare imprinting disorders. Major epigenetic events take place during this time and the process of ART may expose the epigenome to external influences, preventing the proper establishment and maintenance of genomic imprints. However, the risks of ART cannot be simply evaluated because the patients who receive ART may d… Show more

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Cited by 394 publications
(341 citation statements)
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“…[79][80][81][82][83][84][85][86] Abnormal methylation was observed in not only paternally methylated ICRs but also maternally methylated ICRs. At present, it is unclear how defects in methylation imprints are brought about in these patients, but one explanation could be aminoacid sequence variations in DNMT3L.…”
Section: Molar Pregnancy Infertility Assisted Reproductive Technolomentioning
confidence: 99%
“…[79][80][81][82][83][84][85][86] Abnormal methylation was observed in not only paternally methylated ICRs but also maternally methylated ICRs. At present, it is unclear how defects in methylation imprints are brought about in these patients, but one explanation could be aminoacid sequence variations in DNMT3L.…”
Section: Molar Pregnancy Infertility Assisted Reproductive Technolomentioning
confidence: 99%
“…It determines which genes from the paternal and maternal genomes are expressed in the embryo and is critical for normal development [171]. Several loci are known to be imprinted.…”
Section: Epigenetic Modifications and Male Infertilitymentioning
confidence: 99%
“…For instance, in humans, fetal spermatogonia seem to be mostly unmethylated at H19 differentially methylated regions, although spermatogonia in adult testis demonstrate significant methylation in this region [148]. Imprinted genes, including the paternally imprinted GTL2 and H19 loci, have been previously examined by Kobayashi et al, [171] in 97 infertile men. The importance of genomic imprinting during spermatogenesis has been reinforced by the association of decreased methylation of the paternal IGF2⁄H19 imprinting control region 1 (ICR1) and GTL2 imprints in spermatozoa of men with disturbed spermatogenesis.…”
Section: Epigenetic Modifications and Male Infertilitymentioning
confidence: 99%
“…Even where the seminal parameters are normal, ejaculates showing sperm with high DNA damage have been reported 10, 11. Moreover, various epidemiological studies reporting the methylation status of imprinted genes of sperm from severely infertile men show a significant risk of imprinting disorders in offspring conceived by IVF and ICSI 18, 19, 20, 21, 22, 23, 24, 25, 26. These observations strongly argue that the sperm genome provides an epigenetically poised set of developmental genes that potentially have a crucial effect on embryological growth and development.…”
Section: Introductionmentioning
confidence: 99%