Aberrant Epigenetic Modifications in Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein

Park, In Young; Sohn, Bo Hwa; Yu, Eunsil; Suh, Dong Jin; Chung, Young–Hwa; Lee, Je‐Ho; Surzycki, Stefan; Lee, Young Ik

doi:10.1053/j.gastro.2007.01.034

Cited by 284 publications

(300 citation statements)

References 58 publications

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“…However, the presence of DNA methylation at the S and C genes was associated with their lack of expression (Fernandez et al, 2009). HBx is probably involved in the establishment of DNA methylation patterns within the HBV genome in the same way as has been described for host genes (Jung et al, 2007;Park et al, 2007a;Zheng et al, 2009).…”

Section: Hepatitis B Virusmentioning

confidence: 73%

“…It has also been proposed that HBV infection induces epigenetic alterations in host cells (Cougot et al, 2007;Jung et al, 2007;Park et al, 2007a;Herceg and Paliwal, 2009;Shon et al, 2009;Zheng et al, 2009). In such a context, HBx is a key factor initiating epigenetic alterations induced by this virus.…”

Section: Hepatitis B Virusmentioning

confidence: 99%

“…In such a context, HBx is a key factor initiating epigenetic alterations induced by this virus. HBx interacts with DNMTs to produce alterations in the expression of key genes through methylation of their promoters (Jung et al, 2007;Park et al, 2007a;Zheng et al, 2009). DNMT1 expression can be activated by HBx and this increase can then inhibit the expression of tumorsuppressor genes such as p16 or E-cadherin (Jung et al, 2007).…”

Section: Hepatitis B Virusmentioning

confidence: 99%

“…DNMT1 expression can be activated by HBx and this increase can then inhibit the expression of tumorsuppressor genes such as p16 or E-cadherin (Jung et al, 2007). HBx can also regulate the expression of DNMT3a and DNMT3b or interact directly with them, resulting in the hypermethylation or hypomethylation of the promoter regions modulating gene expression (Park et al, 2007a;Zheng et al, 2009). In addition, interactions are known to occur between HBx and the chromatin remodeling machinery components (Cougot Interactions between HBx and histone acetyltransferase (HAT) CBP/p300 are associated with the modulation of gene expression (Cougot et al, 2007), and those with histone deacetylase 1 (HDAC1) have been associated with gene repression (Shon et al, 2009;Zheng et al, 2009).…”

Section: Hepatitis B Virusmentioning

confidence: 99%

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Viral epigenomes in human tumorigenesis

Fernández

Esteller

2010

Oncogene

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Viruses are associated with 15-20% of human cancers worldwide. In the last century, many studies were directed towards elucidating the molecular mechanisms and genetic alterations by which viruses cause cancer. The importance of epigenetics in the regulation of gene expression has prompted the investigation of virus and host interactions not only at the genetic level but also at the epigenetic level. In this study, we summarize the published epigenetic information relating to the genomes of viruses directly or indirectly associated with the establishment of tumorigenic processes. We also review aspects such as viral replication and latency associated with epigenetic changes and summarize what is known about epigenetic alterations in host genomes and the implications of these for the tumoral process. The advances made in characterizing epigenetic features in cancer-causing viruses have improved our understanding of their functional mechanisms. Knowledge of the epigenetic changes that occur in the genome of these viruses should provide us with markers for following cancer progression, as well as new tools for cancer therapy.

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Section: Hepatitis B Virusmentioning

confidence: 73%

Section: Hepatitis B Virusmentioning

confidence: 99%

Section: Hepatitis B Virusmentioning

confidence: 99%

Section: Hepatitis B Virusmentioning

confidence: 99%

See 2 more Smart Citations

Viral epigenomes in human tumorigenesis

Fernández

Esteller

2010

Oncogene

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“…7 HBV X (HBx) is a 16-kDa protein that has been implicated in the enhancement of viral replication, cell death, lipid metabolism, cell cycle regulation, DNA repair, and epigenetic modification. [8][9][10][11][12][13] HBx is frequently expressed in the tissues surrounding the tumor and may be involved in ICC formation. 14 It remains unclear whether the expression of HBx plays a functional role in the pathogenesis of ICC.…”

mentioning

confidence: 99%

A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver

et al. 2012

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Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises

El-Araby

Fouad

Hanbal

et al. 2016

Archiv der Pharmazie

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Cancerous transformation comprises different events that are both genetic and epigenetic. The ultimate goal for such events is to maintain cell survival and proliferation. This transformation occurs as a consequence of different features such as environmental and genetic factors, as well as some types of infection. Many viral infections are considered to be causative agents of a number of different malignancies. To convert normal cells into cancerous cells, oncogenic viruses must function at the epigenetic level to communicate with their host cells. Oncogenic viruses encode certain epigenetic factors that lead to the immortality and proliferation of infected cells. The epigenetic effectors produced by oncogenic viruses constitute appealing targets to prevent and treat malignant diseases caused by these viruses. In this review, we highlight the importance of epigenetic reprogramming for virus-induced oncogenesis, with special emphasis on viral epigenetic oncoproteins as therapeutic targets. The discovery of molecular components that target epigenetic pathways, especially viral factors, is also discussed.

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Aberrant Epigenetic Modifications in Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein

Cited by 284 publications

References 58 publications

Viral epigenomes in human tumorigenesis

Viral epigenomes in human tumorigenesis

A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver

Epigenetic Pathways of Oncogenic Viruses: Therapeutic Promises

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