Aberrant expression of angiopoietin-like proteins 1 and 2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome

Liu, Zhenteng; Liu, Chang; Hao, Cuifang; Xue, Qianwen; Huang, Xin; Zhang, Ning; Bao, Hongchu; Qu, Qinglan

doi:10.3109/09513590.2016.1138463

Cited by 13 publications

(9 citation statements)

References 25 publications

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“…ANGPTL4 protein in mice is most highly expressed in white and brown adipose tissues and to a much lesser extent in other tissues such as ovary, heart, liver, skeletal muscle and intestine [19]. Liu et al (2016) indicate that aberrant expression patterns of ANGPTL1 and ANGPTL2 transcripts in cumulus cells during oocyte maturation is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome (PCOS) [20].…”

Section: Figurementioning

confidence: 99%

The blood vessels development, morphogenesis and blood circulation are three ontologic groups highly up-regulated in porcine oocytes before in vitro maturation

Nawrocki¹,

Celichowski²,

Budna³

et al. 2017

Advances in Cell Biology

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The blood vessels development, morphogenesis and blood circulation are three ontologic groups highly up-regulated in porcine oocytes before in vitro maturation AbstractThe mammalian oocytes undergo significant biochemical and structural modifications during maturation both in vitro and in vivo. These changes involve chromatin reorganization and modification within metabolic status of cytoplasmic organelles. After oocytes' successful maturation the substantially increased storage of RNA was observed. Moreover, the early embryo interaction with maternal endometrial tissue after fertilization is up to now considered as the main marker of proper embryo implantation and early growth. In this study, we first investigated the expression profile of genes involved in blood vessel formation and blood circulation in porcine oocytes before and after in vitro maturation.

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Section: Figurementioning

confidence: 99%

The blood vessels development, morphogenesis and blood circulation are three ontologic groups highly up-regulated in porcine oocytes before in vitro maturation

Nawrocki¹,

Celichowski²,

Budna³

et al. 2017

Advances in Cell Biology

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“…Previous studies have revealed that follicular development disorder, ovulation inhibition and GC apoptosis are associated with the downregulation of nitric oxide (59,60). Liu et al (61) indicated that the abnormal expression patterns of angiopoietin-like (ANGPT) 1 and ANGPTL2 mRNAs in cumulus cells are associated with impaired oocyte developmental competence in PCOS, via pathological angiogenesis and metabolism. Chen et al (62) demonstrated that impaired cystic fibrosis transmembrane conductance regulator (a chloride ion channel) resulted in ovarian disorders by amplifying FSH-stimulated estrogen production in cystic fibrosis and PCOS.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics identification of microRNAs involved in�polycystic ovary syndrome based on microarray data

Hou

Wang²,

Xu³

et al. 2019

Mol Med Report

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Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age. MicroRNAs (miRNAs or miRs) serve important roles in the physiological and pathological process of PCOS. To identify PCOS-associated miRNAs, the dataset GSE84376 was extracted from the Gene Expression Omnibus database. Differentially expressed miRNAs (DE-miRNAs) were obtained from Gene-Cloud Biotechnology Information and potential target genes were predicted using TargetScan, DIANA-microT-CDS, miRDB and miRTarBase tools. Gene Ontology enrichment analysis was performed using Metascape and a protein-protein interaction network was constructed using Cytoscape. Transcription factors were obtained from FunRich. DE-miRNAs were verified by reverse transcription-quantitative PCR. At the screening phase, there were seven DE-miRNAs in the PCOS group not present in the control group. In total, 935 target genes were identified, which are involved in the development and maturation of oocytes. Mitogen-activated protein kinase 1, phosphatase and tensin homolog, cAMP responsive element binding protein 1, signal transducer and activator of transcription 3, interferon γ, Fms-related tyrosine kinase 1, transcription factor p65, insulin receptor substrate 1, DnaJ homolog superfamily C member 10 and casein kinase 2 α 1 were identified as the top 10 hub genes in the protein-protein interaction network. Specificity protein 1 was the most enriched transcription factor. At the validation phase, the levels of Homo sapiens (hsa)-miR-3188 and hsa-miR-3135b were significantly higher in the PCOS group than in the control group. In addition, the expression level of hsa-miR-3135b was significantly correlated with the number of oocytes retrieved, the fertilization rate and the cleavage rate (P<0.05). The present bioinformatics study on miRNAs may offer a novel understanding of the mechanism of PCOS, and may serve to identify novel miRNA therapeutic targets.

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“…An understanding of how CCs and FF influence the acquisition of oocyte competence and protect the oocyte from deleterious systemic and pelvic conditions is important for clinical decision-making in the management of infertility. Disruption of the intrafollicular environment under different pathological conditions [3][4][5][6][7][8][9][10][11][12] has the potential to impact the chance of pregnancy if not treated and/or adjusted in a timely manner. This paper discusses how CCs and FF (and their functional integrity) affect oocyte quality in the context of commonly encountered pathological conditions that are likely to compromise the sustainable environment that is needed to obtain pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

Broi

Giorgi

Wang

et al. 2018

J Assist Reprod Genet

209

135

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An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment.

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Aberrant expression of angiopoietin-like proteins 1 and 2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome

Cited by 13 publications

References 25 publications

The blood vessels development, morphogenesis and blood circulation are three ontologic groups highly up-regulated in porcine oocytes before in vitro maturation

The blood vessels development, morphogenesis and blood circulation are three ontologic groups highly up-regulated in porcine oocytes before in vitro maturation

Bioinformatics identification of microRNAs involved in�polycystic ovary syndrome based on microarray data

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

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