2023
DOI: 10.21203/rs.3.rs-3439470/v1
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Aberrant expression of C1q, IL-6 and β-catenin in class VI lupus nephritis

Jing Xue,
Yu Min,
Zeqin Zhu
et al.

Abstract: Background: complement component C1q, interleukin-6 (IL-6) and β-catenin have been implicated in the pathogenesis of lupus nephritis (LN). However, their correlation with the pathological progression and type of LN remain unclear. Methods: the concentrations of C1q, IL-6 and β-catenin were evaluated in plasma, urine and kidney tissues in LN patients, non-LN systemic lupus erythematosus (SLEn) patients, and healthy cohorts, as well as C57BL/6, IL-6-/-, MRL-Fas/lpr and MRL-Fas/lprIL-6-/- mice. Results: more… Show more

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