Aberrant expression of erythropoietin in uterine leiomyoma: implications in tumor growth

Asano, Ryoko; Asai‐Sato, Mikiko; Miyagi, Yohei; Mizushima, Taichi; Koyama-Sato, Makiko; Nagashima, Yoji; Taguri, Masataka; Sakakibara, Hideya; Hirahara, Fumiki; Miyagi, Etsuko

doi:10.1016/j.ajog.2015.02.016

Cited by 19 publications

(18 citation statements)

References 23 publications

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“…In addition, increasing evidence suggests that EPO contributes to protecting tissues from ischemic damage and tissue remodeling through cell differentiation, control of apoptosis, angiogenesis, and/or vasculogenesis (2). We have previously reported that EPO is on occasion produced in uterine leiomyomas, and EPO messenger RNA (mRNA) levels seem to correlate with bulkier tumors, suggesting that EPO may promote the growth of leiomyomas in an autocrine and/or paracrine manner (3). Because EPO expression in leiomyomas varies dramatically from patient to patient, ranging from undetectable to extremely high levels, we believe that this variability in EPO expression may have bearing on the growth patterns of leiomyomas.…”

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confidence: 99%

Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities

Asano

Asai‐Sato

Matsukuma

et al. 2019

Fertility and Sterility

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Objective: To determine factors that impact erythropoietin (EPO) production in leiomyomas. We have previously implicated EPO production in promoting the growth of some leiomyomas. Design: The relationship between EPO messenger RNA (mRNA) expression and MED12 gene mutations or mRNA expression levels of high-mobility group AT-hook (HMGA) 1 and HMGA2 were analyzed. Effects of 10 À8 M 17b-E 2 on EPO mRNA expression were evaluated using leiomyoma cells grown in primary cultures. Setting: Graduate school of medicine. Patient(s): Patients with leiomyoma. Intervention(s): We used tissue samples and clinical data of 108 patients with leiomyomas to analyze the relation between EPO mRNA expression and MED12 mutation. Tissue samples from another 10 patients with leiomyomas were collected for in vitro experimentation using primary cultures of leiomyoma and myometrial cells. Main Outcome Measure(s): Relations between EPO mRNA expression, MED12 exon 2 mutation, and HMGA1/HMGA2 mRNA expression levels in leiomyoma samplings, in addition to effects of estrogen (E) on EPO mRNA expression in cultures of leiomyoma cells. Result(s): The EPO mRNA level was threefold higher in leiomyomas with wild-type (vs. mutated) MED12 genes. There was no correlation between EPO and HMGA1 or HMGA2 mRNA expression levels. In wild-type MED12 leiomyomas only, E 2 treatment produced a twofold increase in EPO mRNA expression, whereas mutated MED12 leiomyomas were unaffected. Conclusion(s):The EPO mRNA expression increased significantly after E 2 treatment only in leiomyomas lacking MED12 mutations. In conjunction with prior evidence linking EPO mRNA expression levels and tumor size, E 2 -stimulated EPO mRNA expression may explain the marked growth disparities seen in these tumors. (Fertil Steril Ò 2019;111:178-85. Ó2018 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

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confidence: 99%

Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities

Asano

Asai‐Sato

Matsukuma

et al. 2019

Fertility and Sterility

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“…In addition, Asano et al demonstrated that leiomyoma-derived EPO promotes the acceleration of tumor growth. 12 Wolf et al and McDonald et al showed a significant increase in platelet production in animals receiving EPO. 13,14 It has also shown in another study that uterine fibroids secrete PDGF-C, which subsequently promotes the growth of smooth muscle cells of the uterus and uterine fibroids.…”

Section: Discussionmentioning

confidence: 95%

The Role of Mean Platelet Volume on Distinction of Submucosal Myomas from Other Etiologies in Increased Endometrial Thickness

Seçkin

Karslı

Yücel

et al. 2016

Gynecol Obstet Reprod Med

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OBJECTIVE: The aim of the study was to determine whether it is possible to differentiate submucosal fibroids before interventional procedures based on mean platelet volume (MPV), in reproductive-age patients presenting with endometrial thickening and abnormal uterine bleeding. STUDY DESIGN: This study included 581 reproductive-age women who underwent diagnostic procedures (curettage or operative hysteroscopy) and were subsequently divided into two groups based on clinico-pathological findings. The first group included those with benign endometrial pathology (control group, n=438), and the second group consisted of those with submucosal leiomyomas (n=143). The demographic characteristics and complete blood count (CBC) data of these patients were collected retrospectively, and comparisons were made between groups. RESULTS: No statistically significant difference was found between the groups according to demographic features and CBC parameters such as hemoglobin levels and white blood count (p>0,05). Platelet counts were significantly higher and MPV values were significantly lower in submucosal leiomyoma patients compared with the control subjects (p<0,05). CONCLUSIONS: MPV may be a useful predictive marker when differentiating submucosal leiomyoma from other benign causes of abnormal uterine bleeding. The ability to predict the possibility of the presence of submucosal leiomyoma before surgery can assist in determining the most appropriate type of invasive procedure.

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“…Antes del tratamiento definitivo, el SME fue manejado de manera similar a la policitemia vera, a menudo con flebotomías terapéuticas recurrentes para mantener un hematocrito de menos de 45% y así disminuir el riesgo de trombosis. 7,8 Según una revisión de LevGur y Levie, menos de 40 casos de SME se han reportado en la literatura en las últimas seis décadas. 11 Se ha demostrado que la eritrocitosis aislada es el resultado de la producción ectópica de eritropoyetina (Epo) en varias neoplasias malignas, que incluyen células renales y carcinoma hepatocelular.…”

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Eritrocitosis y miomatosis

Troche¹

2020

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Los leiomiomas uterinos son tumores asociados a tumores de eritrocitosis secundaria. En la literatura se ha propuesto y demostrado la producción de eritropoyetina ectópica por fibromas de músculos lisos. Se ha demostrado que la eritrocitosis aislada es el resultado de la producción ectópica de eritropoyetina (Epo) en varias neoplasias malignas que incluyen células renales y carcinoma hepatocelular. Se ha encontrado que ocurre en tumores extraños como el hemangioblastoma cerebeloso y los adenomas. Se le asocia con menos frecuencia a leiomioma uterino. Los cirujanos emplean cada vez más la laparoscopia para la histerectomía. Sin embargo, el papel de la laparoscopia en presencia de un útero gigante todavía es debatible. En pacientes con síndrome miomatoso eritrocitario (SME) presente con signos y síntomas atribuidos a una masa abdominopélvica o eritrocitosis la flebotomía preoperatoria ayuda a disminuir la gravedad de la eritrocitosis y se ha utilizado para mitigar el riesgo de complicaciones trombóticas. La resección quirúrgica del leiomioma es un enfoque válido para el tratamiento de SME.

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Aberrant expression of erythropoietin in uterine leiomyoma: implications in tumor growth

Cited by 19 publications

References 23 publications

Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities

Expression of erythropoietin messenger ribonucleic acid in wild-type MED12 uterine leiomyomas under estrogenic influence: new insights into related growth disparities

The Role of Mean Platelet Volume on Distinction of Submucosal Myomas from Other Etiologies in Increased Endometrial Thickness

Eritrocitosis y miomatosis

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