Aberrant Expression of Long Non Coding RNA HOTAIR and De-Regulation of the Paralogous 13 HOX Genes Are Strongly Associated with Aggressive Behavior of Gastro-Entero-Pancreatic Neuroendocrine Tumors

Mauro, Annabella Di; Scognamiglio, Giosuè; Aquino, Gabriella; Cerrone, Margherita; Liguori, Giuseppina; Clemente, Ottavia; Bonito, Maurizio Di; Cantile, Monica; Botti, Gerardo; Tafuto, Salvatore; Tatangelo, Fabiana

doi:10.3390/ijms22137049

Cited by 9 publications

(4 citation statements)

References 30 publications

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“…In fact, HOTAIR showed weak expression in low-grade GEP NENs and aberrant expression in NET G3 and NEC G3 categories. Furthermore, HOTAIR appeared inversely correlated with posterior HOX genes expression, highlighting that the combined expression can be useful in molecular stratification of GEP-NENs [ 146 ].…”

Section: The Role Of Hotair In Rare Tumorsmentioning

confidence: 99%

The Role of lncRNAs in Rare Tumors with a Focus on HOX Transcript Antisense RNA (HOTAIR)

Liguori

Cerrone

Chiara

et al. 2021

IJMS

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Rare cancers are identified as those with an annual incidence of fewer than 6 per 100,000 persons and includes both epithelial and stromal tumors from different anatomical areas. The advancement of analytical methods has produced an accurate molecular characterization of most human cancers, suggesting a “molecular classification” that has allowed the establishment of increasingly personalized therapeutic strategies. However, the limited availability of rare cancer samples has resulted in very few therapeutic options for these tumors, often leading to poor prognosis. Long non coding RNAs (lncRNAs) are a class of non-coding RNAs mostly involved in tumor progression and drug response. In particular, the lncRNA HOX transcript antisense RNA (HOTAIR) represents an emergent diagnostic, prognostic and predictive biomarker in many human cancers. The aim of this review is to highlight the role of HOTAIR in rare cancers, proposing it as a new biomarker usable in the management of these tumors.

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Section: The Role Of Hotair In Rare Tumorsmentioning

confidence: 99%

The Role of lncRNAs in Rare Tumors with a Focus on HOX Transcript Antisense RNA (HOTAIR)

Liguori

Cerrone

Chiara

et al. 2021

IJMS

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“…LncRNA HOX transcript antisense RNA (HOTAIR) was first discovered to contribute the carcinogenesis of breast cancer through interacting with polycomb repressive complex 2 (PRC2) 11 . During the past years, a number of evidences have demonstrated that HOTAIR function as an important regulator in the development and metastasis of many types of cancer 12,13 . Although these studies revealed some aspects of HOTAIR function in cancer, the effect of HOTAIR on oxaliplatin resistance of GC remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…11 During the past years, a number of evidences have demonstrated that HOTAIR function as an important regulator in the development and metastasis of many types of cancer. 12,13 Although these studies revealed some aspects of HOTAIR function in cancer, the effect of HOTAIR on oxaliplatin resistance of GC remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Dampening HOTAIR sensitizes the gastric cancer cells to oxaliplatin through miR‐195‐5p and ABCG2 pathway

Luo,

Lu,

et al. 2023

J Cellular Molecular Medi

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Long non‐coding RNAs (lncRNA) have an extensive role in the progression and chemoresistance of gastric cancer (GC). Deeply study the regulatory role of lncRNAs could provide potential therapeutic targets. The aim of this study is to explore the regulatory role of HOTAIR in the progression and oxaliplatin resistance of GC. The expression of HOTAIR in GC and cell lines were detected by using qRT‐PCR. Cell proliferation and apoptosis were analysed by CCK‐8, EdU incorporation and flow cytometry. Luciferase reporter assay was used to identify the interaction between HOTAIR and ABCG2 (ATP‐binding cassette (ABC) superfamily G member 2, ABCG2) via miR‐195‐5p. The regulatory functions were verified by using molecular biology experiments. HOTAIR was significantly overexpressed in GC and associated with poor prognosis. Knock‐down of HOTAIR inhibited the GC cells proliferation and oxaliplatin resistance, while overexpression of HOTAIR showed opposite functions. Further studies found that HOTAIR acted as a competing endogenous RNA (ceRNA) to absorb miR‐195‐5p and elevated the expression of ABCG2, which leads to resistance of GC cells to oxaliplatin. Taken together, our findings demonstrated that HOTAIR regulates ABCG2 induced resistance of GC to oxaliplatin through miR‐195‐5p signalling and illustrate the great potential of developing new therapeutic targets for GC patients.

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“…[ 1 ] Gastrointestinal neoplasms, also known as gastroenteropancreatic NETs, account for two-thirds of all NETs. [ 2 ] The incidence of gastroenteropancreatic NETs has been increasing in recent decades. [ 3 , 4 ] GI NETs have now become the second most common gastrointestinal malignancies.…”

Section: Introductionmentioning

confidence: 99%

A gastric neuroendocrine carcinoma with good prognosis after chemotherapy combined with immunotherapy: A case report (CARE-compliant)

Zhao,

Yang,

2023

Medicine

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Introduction: Gastric neuroendocrine carcinoma (GNENs), as a highly malignant gastrointestinal tumor, is characterized by easy postoperative metastasis, and its prognosis has always been poor compared to other gastrointestinal tumors. Due to its rarity, there have been few case reports and studies on it. As of now, there is no clear diagnosis and treatment sequence and guidelines. In this report, we present a case of GNENs that underwent first-line treatment after surgery. The patient achieved an excellent prognosis and survival after a combination of chemotherapy resistance and immunotherapy. This report aims to provide valuable reference and guidance for the treatment of GNENs in the future. Therefore, we conducted a literature review on GNENs. Patient concerns: A 61-year-old man was admitted to the hospital with complaints of upper abdominal distension and discomfort that had been persistent for 1 month. During the endoscopy examination, a 2.5 cm irregular deep mucosal defect was observed at the center of the gastric angle. The defect appeared covered with dirty moss, had a hard texture, and exhibited a tendency to bleed upon contact. Diagnosis: Biopsy results confirmed the presence of a medium to poorly differentiated adenocarcinoma in the gastric horn. Subsequently, the patient underwent surgery, and the removed specimen was diagnosed as GNENs. Intervention: Postoperative chemotherapy combined with immunotherapy Outcome: The patient in this case achieved a good prognosis and extremely long survival [overall survival > 3 years+] after receiving first-line treatment, which included chemotherapy, drug resistance and immunotherapy, and is currently in good health condition. The tumor is not sensitive to the standard EP regimen for neuroendocrine carcinoma, but after being replaced with oxaliplatin based regimen combined with immunotherapy, partial response was obtained, indicating a synergistic effect between chemotherapy and immunity. After treatment, it remained stable for a considerable period of time. Conclusion: Immunotherapy, as a new mode of cancer treatment can provide new guidance and ideas for the treatment of GNENs.

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Aberrant Expression of Long Non Coding RNA HOTAIR and De-Regulation of the Paralogous 13 HOX Genes Are Strongly Associated with Aggressive Behavior of Gastro-Entero-Pancreatic Neuroendocrine Tumors

Cited by 9 publications

References 30 publications

The Role of lncRNAs in Rare Tumors with a Focus on HOX Transcript Antisense RNA (HOTAIR)

The Role of lncRNAs in Rare Tumors with a Focus on HOX Transcript Antisense RNA (HOTAIR)

Dampening HOTAIR sensitizes the gastric cancer cells to oxaliplatin through miR‐195‐5p and ABCG2 pathway

A gastric neuroendocrine carcinoma with good prognosis after chemotherapy combined with immunotherapy: A case report (CARE-compliant)

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