Aberrant Expression of miR-142-3p and its Target Gene HMGA1 and FZD7 in Breast Cancer and its Clinical Significance

Jia, Xiupeng; Meng, Lingli; Fang, Jianchen; Wang, Hongwei; Chen, Jie; Zhou, Jue; Wang, Chun-Nian; Jiang, Weifeng

doi:10.7754/clin.lab.2017.171114

Cited by 18 publications

(9 citation statements)

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“…MiR-124-3p may also be a chronic regulator of gene expression after brain injury [43], therefore, miR-124-3p is a promising therapeutic target for interventions in neuroinflammation after TBI. Additionally, miR-142-3p, which has also long been studied, has been reported in several tumours [44][45][46] and other diseases [47,48]. Its expression in rat hippocampus after TBI has been reported [49], indicating that it may be a sensitive and informative biomarker for forensic assessment of TBI.…”

Section: Discussionmentioning

confidence: 97%

Plasma Exosome-derived MicroRNAs as Novel Biomarkers of Traumatic Brain Injury in Rats

Wang

Zhang

et al. 2020

Int. J. Med. Sci.

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Traumatic brain injury (TBI) is a widespread central nervous system (CNS) condition and a leading cause of death, disability, and long-term disability including seizures and emotional and behavioral issues. To date, applicable diagnostic biomarkers have not been elucidated. MicroRNAs (miRNAs) are enriched and stable in exosomes in plasma. Therefore, we speculated that miRNAs in plasma exosomes might serve as novel biomarkers for TBI diagnosis and are also involved in the pathogenesis of TBI. In this study, we first isolated exosomes from peripheral blood plasma in rats with TBI and then investigated the alterations in miRNA expression in exosomes by high-throughput RNA sequencing. As a result, we identified 50 significantly differentially expressed miRNAs, including 31 upregulated and 19 downregulated miRNAs. Then, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the most highly correlated pathways that were identified were the MAPK signaling pathway, regulation of actin cytoskeleton, Rap1 signaling pathway and Ras signaling pathway. This study provides novel perspectives on miRNAs in peripheral blood plasma exosomes, which not only could be used as biomarkers of TBI diagnosis but could also be manipulated as therapeutic targets of TBI.

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Section: Discussionmentioning

confidence: 97%

Plasma Exosome-derived MicroRNAs as Novel Biomarkers of Traumatic Brain Injury in Rats

Wang

Zhang

et al. 2020

Int. J. Med. Sci.

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“…30,31 The aberrant miR-142-3p expression not only has diagnostic value but also predicts prognosis for cancer patients. 32 Overexpression of miR-142-3p can inhibit the proliferation, invasion, and migration of gastric cancer cells. 33 However, no reports have established the significance of serum miR-142-3p levels in patients with CRC.…”

Section: Introductionmentioning

confidence: 99%

Serum level of miR-142-3p predicts prognostic outcome for colorectal cancer following curative resection

Gao

DeXiang

2019

J Int Med Res

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Objective MicroRNA (miR)-142-3p may function as a tumor suppressor in the development of various cancers. In this study, we measured serum levels of miR-142-3p in patients with colorectal cancer (CRC) to evaluate the diagnostic and prognostic value of miR-142-3p. Methods Serum samples from 363 consecutive CRC patients and 156 healthy controls were retrospectively collected. Serum miR-142-3p levels were measured using real-time quantitative reverse transcription polymerase chain reaction. All patients were followed up regularly after tumor resection. The correlation between serum miR-142-3p level and survival outcomes was analyzed. Results Serum levels of miR-142-3p were significantly lower in CRC patients than in healthy volunteers. A low serum miR-142-3p level was significantly associated with advanced cancer. Survival analysis demonstrated that patients with a low serum miR-142-3p had a lower 5-year overall survival rate than patients with a high serum miR-142-3p level (67.4% vs. 76.9%). Serum miR-142-3p level was also shown to be an independent risk factor for CRC in multivariate analysis (hazard ratio, 2.68; 95% confidence interval: 1.21–7.95). Conclusions Serum miR-142-3p might serve as a useful diagnostic and prognostic marker for CRC.

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“…These findings suggested the potential oncogenic function of HMGA1 in cancer progression. Notably, HMGA1 has been identified as the target of several miRNAs, including miR-26a, miR-195, miR-625 and miR-142-3p (36)(37)(38)(39). miR-26a targets and decreases the expression of HMGA1 and inhibits the migration of osteosarcoma cells (40).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer

Yan

Wang

et al. 2021

Exp Ther Med

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An increasing body of evidence indicates the involvement of microRNAs (miRNAs/miRs) in the initiation and progression of colorectal cancer (CRC). miR-296-5p was recently identified as a tumor suppressor in a variety of human cancer types; however, its function in CRC remains largely unknown. The present study demonstrated that the expression of miR-296-5p was significantly downregulated in CRC tissues and cell lines. The overexpression of miR-296-5p markedly inhibited proliferation, and induced cell cycle arrest and apoptosis in CRC cells. Bioinformatics analysis suggested that high mobility group AT-hook 1 (HMGA1) may be a target of miR-296-5p in CRC cells. Further experiments showed that miR-296-5p bound the 3'-untranslated region of HMGA1 and decreased its expression in CRC cells. HMGA1 was overexpressed in CRC tissues and was inversely correlated with the expression of miR-296-5p. The restoration of HMGA1 significantly reversed the inhibitory effect of miR-296-5p on the proliferation of CRC cells. Overall, the findings of the present study indicate that miR-296-5p suppressed the progression of CRC, at least partially via targeting HMGA1. Thus, miR-296-5p is a potential target for novel therapies in CRC.

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Aberrant Expression of miR-142-3p and its Target Gene HMGA1 and FZD7 in Breast Cancer and its Clinical Significance

Cited by 18 publications

References 0 publications

Plasma Exosome-derived MicroRNAs as Novel Biomarkers of Traumatic Brain Injury in Rats

Plasma Exosome-derived MicroRNAs as Novel Biomarkers of Traumatic Brain Injury in Rats

Serum level of miR-142-3p predicts prognostic outcome for colorectal cancer following curative resection

MicroRNA‑296‑5p inhibits cell proliferation by targeting HMGA1 in colorectal cancer

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