Aberrant expression of oxytocin receptor in endometrium and decidua in women who have experienced recurrent implantation failure

Liu, Chang; Li, Yuehan; Li, Linshuang; Shui, Shike; Liu, Yang; Sui, Cong; Zhang, Hanwang

doi:10.1016/j.xfss.2020.10.004

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…We show that OXTR is also expressed in stromal cells. Studies have shown variable expression of OXTR across the menstrual cycle [ 3 , 35 , 49 ] and in response to endometrial pathologies, including endometriosis, adenomyosis and recurrent implantation failure [ 35 , 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

Global Analysis of Transcription Start Sites and Enhancers in Endometrial Stromal Cells and Differences Associated with Endometriosis

Marla

Mortlock

Yoon

et al. 2023

Cells

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Identifying tissue-specific molecular signatures of active regulatory elements is critical to understanding gene regulatory mechanisms. In this study, transcription start sites (TSS) and enhancers were identified using Cap analysis of gene expression (CAGE) across endometrial stromal cell (ESC) samples obtained from women with (n = 4) and without endometriosis (n = 4). ESC TSSs and enhancers were compared to those reported in other tissue and cell types in FANTOM5 and were integrated with RNA-seq and ATAC-seq data from the same samples for regulatory activity and network analyses. CAGE tag count differences between women with and without endometriosis were statistically tested and tags within close proximity to genetic variants associated with endometriosis risk were identified. Over 90% of tag clusters mapping to promoters were observed in cells and tissues in FANTOM5. However, some potential cell-type-specific promoters and enhancers were also observed. Regions of open chromatin identified using ATAC-seq provided further evidence of the active transcriptional regions identified by CAGE. Despite the small sample number, there was evidence of differences associated with endometriosis at 210 consensus clusters, including IGFBP5, CALD1 and OXTR. ESC TSSs were also located within loci associated with endometriosis risk from genome-wide association studies. This study provides novel evidence of transcriptional differences in endometrial stromal cells associated with endometriosis and provides a valuable cell-type specific resource of active TSSs and enhancers in endometrial stromal cells.

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Section: Discussionmentioning

confidence: 99%

Global Analysis of Transcription Start Sites and Enhancers in Endometrial Stromal Cells and Differences Associated with Endometriosis

Marla

Mortlock

Yoon

et al. 2023

Cells

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show abstract

“…Generally, an increase of plant tissue N with soil N will ultimately increase plant N accumulation and grain yield [53]. Deep N and P fertilizer placement increases nutrient availability in the maize root zone for a longer period of growth requirement [54], which can promote root length, proliferation, and penetration capacity, as well as water and N uptake, and thereby plant tissue N accumulation and biomass production [54][55][56]. Our results are in accordance with these previous studies, e.g., Fageria et al [57] reported positive relationships between soil NO3 − and plant tissue N. Jiang et al [22] showed that maize tissue N accumulation increased with increasing N fertilization rates from N135, N150 to N180 kg ha −1 .…”

Section: Variations In Relationships Between Concentrations Of Tissue...mentioning

confidence: 99%

Variation in Nitrogen Accumulation and Use Efficiency in Maize Differentiate with Nitrogen and Phosphorus Rates and Contrasting Fertilizer Placement Methodologies

Sharifi,

Shi,

Dong

et al. 2023

Preprint

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Balanced nitrogen (N) and phosphorus (P) rates coupling with rational fertilization methodology could promote crop N accumulation, N use efficiency and yield production, particularly in semi-arid and arid regions. To test these characteristics, a two-year (2018 and 2019) pot experiment was therefore performed by growing summer maize in a rain-proof glass greenhouse, under 9 combined N (112, 150 and 187 kg ha-1, urea) and P (45, 60, 75 kg ha-1, calcium superphosphate) rates and three contrasting fertilizer placements. The fertilizers were placed by broadcast on soil surface (Broadcast), side band on 4 cm strip soil surface within 7 cm from sowing line (Side band) and deep band on 4 cm strip below 7 cm soil depth within 7 cm from sowing line (Deep band). Results from three maize growth stages (eight-leaf, 45 days after sowing, DAS; tasseling, 60 DAS; and harvest, 115 DAS) showed that leaf, stem, root N accumulation and total soil N were significantly increased under Deep band than under both Side band and Broadcast at N150P60, N187P60, N150P75 and N187P75, but not at N112P45, N150P45, N187P45, N112P60 and N112P75. Significantly greater leaf, stem, and root N accumulations were also displayed at N150 and N187 than at N112 for the same P60 or P75 under Deep band at 60 DAS and 115 DAS, while were for leaf and stem N accumulations at P75 and P60 than at P45 for the same N150 under Deep band at 45 DAS, 60 DAS and 115 DAS. Significantly greater agronomy N use efficiency, partial factor productivity and N use efficiency exhibited under Deep band than under Side band and Broadcast at N150P75 and N187P75, but at N150P60 and N187P60 for NUE only. In addition, leaf, stem, seed, root N concentrations positively correlated with their own N accumulations or soil N concentration at tasseling and harvest stages. Our results demonstrate that a synchronized N150P60, N187P60, N150P75 or N187P75 fertilization rate with Deep band placement can improve soil N availability and root N uptake, and hereby greater aboveground N accumulation, N use efficiency and yield production of maize particularly practical for small-holder farmers globally.

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Aberrant expression of oxytocin receptor in endometrium and decidua in women who have experienced recurrent implantation failure

Cited by 2 publications

References 28 publications

Global Analysis of Transcription Start Sites and Enhancers in Endometrial Stromal Cells and Differences Associated with Endometriosis

Global Analysis of Transcription Start Sites and Enhancers in Endometrial Stromal Cells and Differences Associated with Endometriosis

Variation in Nitrogen Accumulation and Use Efficiency in Maize Differentiate with Nitrogen and Phosphorus Rates and Contrasting Fertilizer Placement Methodologies

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