Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells

Zhuang, Hao; Zhao, Mingjun; Hei, Kaiwen; Yang, Baohong; Sun, Li; Du, Xue; Li, Yongmei

doi:10.7314/apjcp.2015.16.8.3325

Cited by 18 publications

(16 citation statements)

References 37 publications

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“…These results suggest that PIM kinases may affect OS metastasis. In agreement with this, previous studies have suggested a role for PIM kinases in cell motility and metastasis, for example, PIM1 was able to promote migration in leukemia and prostate cancer cells (48), PIM2 was shown to induce human liver cell malignant transformation and increase the migration rate (49), and PIM3 can promote ovarian cancer cell migration (50). In addition, absence of PIM kinases blocks the process of bone invasion induced by the 3-methylcholanthrene-induced sarcoma in vivo (51).…”

Section: Discussionsupporting

confidence: 87%

Expression and function of PIM kinases in osteosarcoma

Mou

Wang

Ding

et al. 2016

International Journal of Oncology

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The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies. However, their role in osteosarcoma (OS) remains largely unknown. This study aimed to examine the expression patterns and the clinical significance of PIM kinases in human OS and their biological effects in human OS cell lines. Immunohistochemical staining was used to detect PIM kinases in archived pathologic material from 43 patients with primary OS; in addition, the effects of PIM knockdown and overexpression on the proliferation, migration and invasion of OS cell lines were determined. We observed that all three PIM kinases were frequently expressed in OS, but only PIM1 positive expression was associated with poorer prognosis regarding overall survival of OS patients. In addition, knockdown of PIM kinases notably inhibited OS cell proliferation, migration and invasiveness, whereas overexpression of PIM kinases resulted in increased OS cell growth and motility. This study suggests that PIM1 could be a valuable prognostic marker in patients with OS, and the biological functions of PIM kinase family in the osteosarcoma cell lines indicate that they could serve as potential therapeutic targets for OS.

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Section: Discussionsupporting

confidence: 87%

Expression and function of PIM kinases in osteosarcoma

Mou

Wang

Ding

et al. 2016

International Journal of Oncology

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“…Impaired expression of MACC1 is associated with several malignant tumors. MACC1 down-regulation in OC cells inhibits migration, invasion and proliferation of these cells, and increases the apoptosis [ 11 ]. MACC1 inhibition suppresses the growth and metastatic OC cells in vivo and in vitro.…”

Section: Pim Kinases and Proteins Involved In Cellular Functions Omentioning

confidence: 99%

“…Recently, it has been reported that MACC1 and PIM kinases are correlated to each other and they have similar role. PIM3 and MACC1 [ 11 ] expressions have also been reported higher in OC tissues as compared to other tissues [ 11 ]. However, the mechanism by which PIM3 regulates the MACC1 expression is still unknown.…”

Section: Pim Kinases and Proteins Involved In Cellular Functions Omentioning

confidence: 99%

“…PIM3 over expression in OC cells enhances metastasis-associated in colon cancer-1 (MACC1) mRNA and protein expressions, which promote the SKOV3 cell line migration and proliferation. It suggests that PIM3 is a putative oncogene in SKOV3 cell line [ 11 ]. SKOV3 cell line has been characterized as “unlikely high grade” and it cannot be a good model to study OC [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer

et al. 2018

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Ovarian cancer is a medical term that includes a number of tumors with different molecular biology, phenotypes, tumor progression, etiology, and even different diagnosis. Some specific treatments are required to address this heterogeneity of ovarian cancer, thus molecular characterization may provide an important tool for this purpose. On a molecular level, proviral-integration site for Moloney-murine leukemia virus (PIM) kinases are over expressed in ovarian cancer and play a vital role in the regulation of different proteins responsible for this tumorigenesis. Likewise, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is also a central regulator of the ovarian cancer. Interestingly, recent research has linked the PIM kinases to the PI3K/AKT/mTOR pathway in several types of cancers, but their connection in ovarian cancer has not been studied yet. Once the exact relationship of PIM kinases with the PI3K/AKT/mTOR pathway is acquired in ovarian cancer, it will hopefully provide effective treatments on a molecular level. This review mainly focuses on the role of PIM kinases in ovarian cancer and their interactions with proteins involved in its progression. In addition, this review suggests a connection between the PIM kinases and the PI3K/AKT/mTOR pathway and their parallel mechanism in the regulation of ovarian cancer.

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“…Uncontrolled growth of the tumor would be triggered by these changes. Thirdly, previous research on solid tumors and leukemia 14 , 15 , 17 indicated that Pim-3 expression may have important effects on p53 or on other members of the anti-apoptosis Bcl-2 protein family. As the most important apoptosis-inducing gene in the body, p53 critically influences the mitochondrial and death receptor pathways, which are both important for apoptosis.…”

Section: Discussionmentioning

confidence: 98%

Pim-3 as a potential predictor of chemoradiotherapy resistance in locally advanced rectal cancer patients

Zhang

Zhou

et al. 2017

Sci Rep

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Approximately 30% of locally advanced rectal cancer patients might not benefit from chemoradiotherapy; however, the response to neoadjuvant chemoradiotherapy in these cases is difficult to predict. Pim-3 is a member of the provirus integration site for a moloney murine leukemia virus family of proteins that contributes to cell proliferation, survival, and chemotherapy resistance. Therefore, the relationship between Pim-3 expression and response to neoadjuvant chemoradiotherapy in rectal cancer patients is important to evaluate. 175 rectal cancer patients who underwent neoadjuvant treatment enrolled in this study. The relationship between Pim-3 expression on immunohistochemical analysis of rectal cancer tissue, which was obtained before treatment, the response to chemoradiotherapy and survival was investigated. The patients with no Pim-3 expression were more likely to achieve a pathologic complete response to chemoradiotherapy than patients with Pim-3 expression (P = 0.001). Cox multivariate analysis showed that the significant prognostic factors were Pim-3 expression (P = 0.003) and the number of neoadjuvant chemotherapy cycles (P = 0.005) for overall survival. Neoadjuvant chemotherapy cycles (P = 0.007), adjuvant chemotherapy cycles (P = 0.004) and pathology types (P = 0.049) were significant prognostic factors for disease-free survival. Pim-3 is a potential predictive biomarker for the response of rectal cancer to chemoradiotherapy.

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Aberrant Expression of Pim-3 Promotes Proliferation and Migration of Ovarian Cancer Cells

Cited by 18 publications

References 37 publications

Expression and function of PIM kinases in osteosarcoma

Expression and function of PIM kinases in osteosarcoma

PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer

Pim-3 as a potential predictor of chemoradiotherapy resistance in locally advanced rectal cancer patients

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