Aberrant fissure in polymicrogyria

Abstract

SUMMARYObjective: Polymicrogyria (PMG) is the most common malformation of the brain cortex. There is an impaired migration and proliferation of neuronal cells leading to a thickened cortex with multiple small (micro) gyri. It can be focal or diffuse. The aim of this study is to delineate the MRI properties of an aberrant fissure (AF) associated with PMG. Method: MR images of 34 patients were retrospectively investigated for the features of PMG, the presence of an AF and its properties along with the clinical findings. Results: Thirty-one patients (91.2%) showed focal PMG, whereas 3 patients (8.8%) had diffuse involvement of the brain. None of the diffuse PMGs showed an AF, whereas 30 patients (88%) with focal PMG showed an associated AF. Only one patient with a focal PMG did not display an AF, however, he had an arachnoid cyst adjacent to the PMG. AFs were related to or in continuity with major fissures of the brain in 27 subjects. Conclusions: An AF is present in the vast majority of patients with a focal PMG, however, there is no significant relation between the presence of AF and clinical findings. Keywords: Aberrant fissure, magnetic resonance imaging, polymicrogyria ÖZET Amaç: Polimikrogiri (PMG) beyin korteksinin en sık görülen malformasyonudur. Beyin gelişimi sırasında nöronal migrasyonun son evresinde ve migrasyon sonrası korteks organizasyonunda bozukluk mevcuttur. PMG fokal veya diffüz olabilir. Bu çalışmanın amacı PMG'de görülen aberran fissürün (AF) MR özelliklerini ortaya koymaktır. Yöntem: PMG tanısı alan 34 hastanın manyetik rezonans görüntüleme (MRG) bulguları ve dosya bilgileri PMG özellikleri, AF varlığı ve özellikleri ile klinik bulguları yönünden retrospektif olarak değerlendirildi. Bulgular: 34 hastanın 31'inde (% 91.2) fokal, 3'ünde (% 8.8) diffüz PMG görüldü. Diffüz PMG'li 3 olguda AF izlenmedi. Fokal PMG li 30 olguda AF saptandı. AF saptanmayan bir fokal PMG olgusunda PMG komşuluğunda araknoid kist mevcuttu. 27 hastada AF beynin bilinen majör fissürleri ile ilişkiliydi ya da onlarla devamlılık gösteriyordu. Sonuç: Fokal PMG li olguların büyük çoğunluğunda AF izlenmekle birlikte klinik bulgular ile anlamlı ilişkisi yoktur. Anahtar sözcükler: Aberran fissür, manyetik rezonas görüntüleme, polimikrogiri CMJ

Different Polymicrogyria patterns and associated anomalies in childhood: MRI findings

“…PMG can be seen in all lobes. PMG most often holds the sylvian fissure and posterior portion [8][9][10][11] .…”

“…Polymicrogyria can be isolated or with different morphological or genetic malformations. The most common anomalies associated with PMG are corpus callosum dysgenesis / agenesis / hypogenesis, cerebellar hypoplasia and gray matter heterotopia 9 . In addition to these anomalies, the type of perisylvian may be associated with chromosomal deletion and duplication anomalies such as DiGeorge syndrome 6,7 .…”