Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Liu, Mengqi; Huang, Yang; Li, Xuemei; Liu, Yang; Yu, Renqiang; Long, Yicheng; Lv, Fajin

doi:10.3389/fpsyt.2022.1007144

Cited by 9 publications

(5 citation statements)

References 61 publications

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“…Our findings are partially in line with previous studies that reported abnormal ALFF values in the temporal and fusiform gyrus in depressed adolescents (7,24,25). For example, Cao et al found that young depressed patients with suicidal behavior had increased baseline brain activity in the left middle temporal gyrus (l-MTG) compared to those without suicidal behavior (7).…”

Section: Discussionsupporting

confidence: 93%

“…Interestingly, when combining the mean ALFF values of both regions, relatively successful discrimination was achieved, suggesting that a combination of different biomarkers may provide a better prediction of suicide attempts and infer a potential suicide risk in depressed adolescents. Our research findings are consistent with some of the results in the literature but also have some differences (7,25,45). Unlike Cao et al we did not find significant differences in the ALFF values in the l-SFG and l-MFG between the two groups, nor did this region have a good discriminative capability (7).…”

Section: Discussionsupporting

confidence: 91%

“…Our research, along with previous findings, suggests that abnormal brain activity and functional connectivity in specific brain regions, including the temporal and fusiform gyri, may play a role in the pathogenesis of depression and suicidal behavior in adolescents. However, there are also differences among studies, such as the specific brain regions identified and the populations studied (e.g., males vs. females) (25). The inferior temporal gyrus is involved in visual processing, memory, and emotion recognition (28), and the fusiform gyrus is associated with face perception, social cognition, and empathy (29, 30).…”

Section: Discussionmentioning

confidence: 99%

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The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study

Jiang

Huang

et al. 2023

Front. Psychiatry

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BackgroundThe amplitude of low-frequency fluctuation (ALFF) is a measure of spontaneous brain activity derived from resting-state functional magnetic resonance imaging (rs-fMRI). Previous research has suggested that abnormal ALFF values may be associated with major depressive disorder (MDD) and suicide attempts in adolescents. In this study, our aim was to investigate the differences in ALFF values between adolescent MDD patients with and without a history of suicide attempts, and to explore the potential utility of ALFF as a neuroimaging biomarker for aiding in the diagnosis and prediction of suicide attempts in this population.MethodsThe study included 34 adolescent depression patients with suicide attempts (SU group), 43 depression patients without suicide attempts (NSU group), and 36 healthy controls (HC group). Depression was diagnosed using a threshold score greater than 17 on the Hamilton Depression Rating Scale (HDRS). The rs-fMRI was employed to calculate zALFF values and compare differences among the groups. Associations between zALFF values in specific brain regions and clinical variables such as emotion regulation difficulties were explored using Pearson partial correlation analysis. Receiver-Operating Characteristics (ROC) analysis assessed the ability of mean zALFF values to differentiate between SU and NSU groups.ResultsSignificant differences in zALFF values were observed in the left and right inferior temporal gyrus (l-ITG, r-ITG) and right fusiform gyrus (r-FG) among the three groups (GRF corrected). Both SU and NSU groups exhibited increased zALFF values in the inferior temporal gyrus compared to the HC group. Furthermore, the SU group showed significantly higher zALFF values in the l-ITG and r-FG compared to both the NSU group and the HC group. Partial correlation analysis revealed a negative correlation between zALFF values in the left superior and middle frontal gyrus (l-SFG, l-MFG) and the degree of emotional dysregulation in the SU group (R = −0.496, p = 0.003; R = −0.484, p = 0.005). Combining zALFF values from the l-ITG and r-FG achieved successful discrimination between depressed adolescents with and without suicide attempts (AUC = 0.855) with high sensitivity (86%) and specificity (71%).ConclusionDepressed adolescents with suicidal behavior exhibit unique neural activity patterns in the inferior temporal gyrus and fusiform gyrus. These findings highlight the potential utility of these specific brain regions as biomarkers for identifying suicide risk in depressed adolescents. Furthermore, associations between emotion dysregulation and activity in their frontal gyrus regions were observed. These findings provide preliminary yet pertinent insights into the pathophysiology of suicide in depressed adolescents.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study

Jiang

Huang

et al. 2023

Front. Psychiatry

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“…As mentioned in Methods, we conducted an additional updated search in May 2023, after the data synthesis had been performed and the brain model of suicidal behavior in youth had been built. The search resulted in 8 papers that met the inclusion criteria [58][59][60][61][62][63][64][65]. To preserve the order of the data synthesis-in which we begin with the systematic literature search first, without any specific model in mind, then perform a narrative synthesis, and finally propose a model-we did not include the 8 additional papers in the synthesis and instead compared the findings in these papers to our END model as to whether they support or contradict it.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of MRI Studies and the “Emotional paiN and social Disconnect (END)” Brain Model of Suicidal Behavior in Youth

Tymofiyeva,

Reeves,

Shaw

et al. 2023

Behavioural Neurology

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Introduction. Risk of suicidal ideation and suicidal behaviors greatly increases during adolescence, and rates have risen dramatically over the past two decades. However, few risk factors or biomarkers predictive of suicidal ideation or attempted suicide have been identified in adolescents. Neuroimaging correlates hold potential for early identification of adolescents at increased risk of suicidality and risk stratification for those at high risk of suicide attempt. Methods. In this systematic review, we evaluated neural regions and networks associated with suicidal ideation and suicide attempt in adolescents derived from magnetic resonance imaging (MRI) studies. A total of 28 articles were included in this review. Results. After descriptively synthesizing the literature, we propose the Emotional paiN and social Disconnect (END) model of adolescent suicidality and present two key neural circuits: (1) the emotional/mental pain circuit and (2) the social disconnect/distortion circuit. In the END model, the emotional pain circuit—consisting of the cerebellum, amygdala, and hippocampus—shows similar aberrations in adolescents with suicidal ideation as in those with a history of a suicide attempt (but to a smaller degree). The social disconnect circuit is unique to adolescent suicide attempters and includes the lateral orbitofrontal cortex (OFC), the temporal gyri, and the connections between them. Conclusion. Our proposed END brain model of suicidal behavior in youth, if confirmed by future prospective studies, can have implications for clinical goals of early detection, risk stratification, and intervention development. Treatments that target emotional pain and social disconnect may be ideal interventions for reducing suicidality in adolescents.

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“…Recently a study has calculated a suicide prevalence of 8.76 per 100,000 inhabitants in Mexico and previous reports have estimated 804,000 annual suicides worldwide (Cabello-Rangel et al, 2020). Major Depressive Disorder (MDD) is one of the most common mental disorders, affecting over 320 million people worldwide, and has been associated with an increased risk of suicidal ideation (SI), suicide attempts (SA), and completed suicide (Liu et al, 2022;Xu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism rs754203 in Gene CYP46A1 Is a Potential Suicide Risk Biomarker in Major Depressive Disorder

Serna-Rodríguez¹,

Cienfuegos-Jiménez²,

Cerda‐Flores³

et al. 2023

Preprint

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Background: Currently, completed suicide, suicide ideation, suicide behavior, and suicide attempts are major public health problems worldwide. Major Depressive Disorder (MDD) is one of the most common mental disorders associated with an increased risk of suicide. Since the relationship between suicide and cholesterol levels is still controversial, in this study, we explore the association between SNPs rs754203 and rs4900442 of CYP46A1 with suicide risk in Mexican patients with major depressive disorder. Methods: We evaluated 188 unrelated suicide completers and compared them to 144 non-suicidal individuals (controls) and 126 MDD patients. Genotypes were analyzed using the Real Time-polymerase chain reaction method and two allele-specific probes to detect specific SNP targets. A chi-square test was used to identify a possible risk genotype or allele type for suicide. Results: Statistical analysis showed significant differences between completed suicide and controls in their allelic and genotypic frequencies in rs754203 SNP. The genotype G/G of CYP46A1 rs754203 was significantly associated with suicide. Also, the G allele was associated with an increased risk of suicide (OR= 1.370, 95% CI= 1.002-1.873). No differences in either genotype distribution or allele frequencies of CYP46A1 rs4900442 were observed. Conclusions: The results of the current study report the first association between G allele carriers (A/G + G/G) of rs754203 and increased risk for suicide, especially in males.

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Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study

Cited by 9 publications

References 61 publications

The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study

The amplitude of low-frequency fluctuation characteristics in depressed adolescents with suicide attempts: a resting-state fMRI study

A Systematic Review of MRI Studies and the “Emotional paiN and social Disconnect (END)” Brain Model of Suicidal Behavior in Youth

Polymorphism rs754203 in Gene CYP46A1 Is a Potential Suicide Risk Biomarker in Major Depressive Disorder

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