Aberrant high expression of the TET1 gene in Hirschsprung's disease

Yang, Shaobo; Yu, Jianhua; Ye, Hong; Zheng, Wanwei; Zhao, Ying; Huang, Yanlei; Chen, Gong; Zheng, Shusen

doi:10.1016/j.pedneo.2022.03.003

Cited by 3 publications

(2 citation statements)

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“…67) and increased expression of the demethylation enzyme TET1 in intestinal samples from patients with HSCR (Ref. 68). These findings support the role for a complex interplay between methylation and demethylation in regulating the formation of the enteric nervous system.…”

Section: Hirschsprung's Diseasementioning

confidence: 99%

DNA methylation in necrotizing enterocolitis

Frazer,

Yamaguchi,

Singh

et al. 2024

Expert Rev. Mol. Med.

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Epigenetic modifications, such as DNA methylation, are enzymatically regulated processes that directly impact gene expression patterns. In early life, they are central to developmental programming and have also been implicated in regulating inflammatory responses. Research into the role of epigenetics in neonatal health is limited, but there is a growing body of literature related to the role of DNA methylation patterns and diseases of prematurity, such as the intestinal disease necrotizing enterocolitis (NEC). NEC is a severe intestinal inflammatory disease, but the key factors that precede disease development remain to be determined. This knowledge gap has led to a failure to design effective targeted therapies and identify specific biomarkers of disease. Recent literature has identified altered DNA methylation patterns in the stool and intestinal tissue of neonates with NEC. These findings provide the foundation for a new avenue in NEC research. In this review, we will provide a general overview of DNA methylation and then specifically discuss the recent literature related to methylation patterns in neonates with NEC. We will also discuss how DNA methylation is used as a biomarker for other disease states and how, with further research, methylation patterns may serve as potential biomarkers for NEC. 6Lauren C. Frazer et al.

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Section: Hirschsprung's Diseasementioning

confidence: 99%

DNA methylation in necrotizing enterocolitis

Frazer,

Yamaguchi,

Singh

et al. 2024

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

show abstract

“…Diseases associated with TET1 include Glioblastoma and Rett Syndrome and cervical cancer. The important paralog of this gene is TET2 (13)(14)(15)(16)(17). Figure 1(C) shows the location of this gene on the chromosome.…”

Section: Tet1 Genementioning

confidence: 99%