Aberrant<i>Ascaris suum</i>Nematode Infection in Cattle, Missouri, USA

Taylor, Holly L.; Spagnoli, Sean; Calcutt, Michael J.; Kim, Dae Y.

doi:10.3201/eid2202.150686

Cited by 9 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pig roundworm A. suum has been suggested as causing a widely distributed zoonosis with human cases in North America, Europe and Asia [2,3,6]. Some other animals infected with A. suum have been also recently reported [7]. Our finding shows that this roundworm can infect dogs.…”

Section: Letter To the Editorsupporting

confidence: 56%

“…Importantly, cases of A. suum-related human infections have been reported [3][4][5], including an outbreak in Maine, USA, in 2010-2013 [6]. In addition, aberrant A. suum infections were also reported in domestic animals, such as cattle [7]. Here we expand the currently recognized infection spectrum by firstly describing A. suum infection in domestic dogs in China.…”

Section: Letter To the Editormentioning

confidence: 83%

See 1 more Smart Citation

First report on aberrant Ascaris suum infection in a dog, China

Xie

Liu

et al. 2020

Parasites Vectors

View full text Add to dashboard Cite

show abstract

Section: Letter To the Editorsupporting

confidence: 56%

Section: Letter To the Editormentioning

confidence: 83%

First report on aberrant Ascaris suum infection in a dog, China

Xie

Liu

et al. 2020

Parasites Vectors

View full text Add to dashboard Cite

show abstract

“…In high-income countries, many indigenous infections are thought to originate from zoonotic A. suum [ 19 ]. Incident zoonotic transmission can occur within other mammalian species including horses, racoons, dogs, cows, and marine mammals [ 20 ]. Human and animal transmission primarily ensues through the fecal oral route when embryonated eggs are ingested from contaminated soil or feces.…”

Section: Five Sths Of Public Health Importancementioning

confidence: 99%

“…As both A. lumbricoides and A. suum have been documented to cause infection in humans, many of these recent case reports have occurred in agricultural areas. Infections common in commercial and feral swine [ 44 ] have also been documented in other mammalian species, like cattle in Missouri and Iowa [ 20 , 36 ].…”

Section: What Is Known About Sth In the Usa?: Past And Presentmentioning

confidence: 99%

Soil-Transmitted Helminths in the USA: a Review of Five Common Parasites and Future Directions for Avenues of Enhanced Epidemiologic Inquiry

2021

View full text Add to dashboard Cite

Purpose of Review The aim of this review is to present a comprehensive look at five intestinal soil-transmitted helminths (STHs) of global health importance that may continue to plague low-income and rural areas of the USA and argue the need for enhanced surveillance of these infections, which primarily affect the nation's most vulnerable groups. Recent Findings Human STH infections in middle-and high-income countries are at particular risk for being undiagnosed; as common symptoms are non-specific, differentials require a high index of clinical suspicion, and cases are concentrated in areas of poverty where access to care is limited. Although autochthonous STHs are thought to be rare in the USA, infections were once common in the American South and Appalachia and robust epidemiologic surveillance is limited post 1980s. However, recent community studies and case reports from small-scale farms and areas of high rural or inner-city poverty reveal the potential for persisting helminth infections in distinct populations of the country. Summary STHs are among the most common neglected tropical diseases globally causing significant morbidity in underserved communities and contributing to the continuation of cycles of poverty within vulnerable populations. Due to possible severe disease sequalae and their ability to perpetuate poverty and poverty-associated health outcomes within already vulnerable groups, it is vital that surveillance for these infections is enhanced to bolster health equity in the USA.

show abstract

“…Ascaris , a genus of clade III nematode parasites, are gastrointestinal roundworms that infect humans, pigs and other animals worldwide (Taylor et al., 2016) and have been estimated to cause more than 1.2 billion human infections (de Silva et al., 2003). In developing countries, the control of Ascaris infection relies on the limited number of available anthelmintic drugs.…”

Section: Introductionmentioning

confidence: 99%

(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu -ACR-16 receptor

Zheng

Chou

et al. 2017

International Journal for Parasitology: Drugs and Drug Resistan

View full text Add to dashboard Cite

Nematode parasites infect ∼2 billion people world-wide. Infections are treated and prevented by anthelmintic drugs, some of which act on nicotinic acetylcholine receptors (nAChRs). There is an unmet need for novel therapeutic agents because of concerns about the development of resistance. We have selected Asu-ACR-16 from a significant nematode parasite genus, Ascaris suum, as a pharmaceutical target and nicotine as our basic moiety (EC50 6.21 ± 0.56 μM, Imax 82.39 ± 2.52%) to facilitate the development of more effective anthelmintics.We expressed Asu-ACR-16 in Xenopus oocytes and used two-electrode voltage clamp electrophysiology to determine agonist concentration-current-response relationships and determine the potencies (EC50s) of the agonists.Here, we describe the synthesis of a novel agonist, (S)-5-ethynyl-anabasine, and show that it is more potent (EC50 0.14 ± 0.01 μM) than other nicotine alkaloids on Asu-ACR-16. Agonists acting on ACR-16 receptors have the potential to circumvent drug resistance to anthelmintics, like levamisole, that do not act on the ACR-16 receptors.

show abstract

AberrantAscaris suumNematode Infection in Cattle, Missouri, USA

Cited by 9 publications

References 8 publications

First report on aberrant Ascaris suum infection in a dog, China

First report on aberrant Ascaris suum infection in a dog, China

Soil-Transmitted Helminths in the USA: a Review of Five Common Parasites and Future Directions for Avenues of Enhanced Epidemiologic Inquiry

(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu -ACR-16 receptor

Contact Info

Product

Resources

About