Aberrant interhemispheric functional connectivity in major depressive disorder with and without anhedonia

Lu, Shengyong; Shao, Jian‐Zhong; Feng, Qian; Wu, Congchong; Fang, Zhe; Jia, Lili; Wang, Zheng; Hu, Shaohua; Xu, Yi; Huang, Manli

doi:10.1186/s12888-022-04343-x

Cited by 19 publications

(12 citation statements)

References 55 publications

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“…In addition, MFG is one part of dlPFC, get closely correlated with eudemonia well-being (113). And the increased Voxel-mirrored homotopic connectivity values in the SFG in MDD patients with anhedonia were found from a recent study (114). We speculate that decreased rsFC of right Nac core-like subdivision with right MFG and right SFG in MDD patients indicates that the reward system in MDD with consummatory anhedonia is disrupted.…”

Section: Discussionmentioning

confidence: 54%

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

Zhao

et al. 2022

Preprint

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Background: The nucleus accumbens (Nac) is a crucial brain region in the pathophysiology of MDD patients with anhedonia. However, the relationship between functional imaging characteristics of Nac subregions and anhedonia remains unclear. Thus, this study aimed to investigate the role of functional connectivity of the Nac subregions between MDD and anhedonia. Methods: We conducted resting-state functional magnetic resonance imaging (fMRI) to measure the resting-state functional connectivity (rsFC) of Nac subregions in 55 MDD patients and 30 healthy controls (HC). A two-sample t-test was performed to obtain the different brain regions with Nac subregions between groups respectively. Then correlation analyses were carried out to investigate the relationships between the aberrant rsFC of Nac subregions and the severity of anhedonia. Furthermore, we constructed a mediation model to explain the role of the aberrant rsFC of Nac subregions between MDD and the severity of anhedonia. Results: The results show that decreased rsFC of Nac subregions with regions of the prefrontal cortex, insula, lingual, and visual association cortex in MDD patients compared with the HC group. In the MDD group, the rsFC of the right Nac shell-like subregions with middle frontal gyrus (MFG)/superior frontal gyrus (SFG) was correlated with consummatory anhedonia; and the rsFC of the Nac core-like subdivisions with inferior frontal gyrus/insula and lingual/visual association cortex was correlated with anticipatory anhedonia. More importantly, the functional alterations of the Nac subregions mediated the association between anhedonia and depression. Conclusions: The present findings suggest the functional alteration of the Nac subregions mediates the association between MDD and anhedonia, which provides evidence for the hypothesis that MDD has different neurobiological underpinnings of reward systems from HC.

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Section: Discussionmentioning

confidence: 54%

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

Zhao

et al. 2022

Preprint

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“…Cerebral functional nodal characteristics of the left SFG were associated with the severity of consummatory anhedonia in MDD patients with severe anhedonia [ 103 ]. And abnormal voxel-mirrored homotopic connectivity values in the SFG in MDD patients with anhedonia were found in a recent study [ 104 ]. During the reward outcome stage, the right MFG showed decreased activation in MDD patients compared to controls [ 105 ].…”

Section: Discussionmentioning

confidence: 94%

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

Zhao

et al. 2023

BMC Psychiatry

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Background The nucleus accumbens (Nac) is a crucial brain region in the pathophysiology of major depressive disorder (MDD) patients with anhedonia. However, the relationship between the functional imaging characteristics of Nac subregions and anhedonia remains unclear. Thus, this study aimed to investigate the role of resting-state functional connectivity (rsFC) of the Nac subregions between MDD and anhedonia. Methods We performed resting-state functional magnetic resonance imaging (fMRI) to measure the rsFC of Nac subregions in 55 MDD patients and 30 healthy controls (HCs). A two-sample t test was performed to determine the brain regions with varying rsFC among Nac subregions between groups. Then, correlation analyses were carried out to investigate the relationships between the aberrant rsFC of Nac subregions and the severity of anhedonia. Furthermore, we constructed a mediation model to explain the role of the aberrant rsFC of Nac subregions between MDD and the severity of anhedonia. Results Compared with the HC group, decreased rsFC of Nac subregions with regions of the prefrontal cortex, insula, lingual gyrus, and visual association cortex was observed in MDD patients. In the MDD group, the rsFC of the right Nac shell-like subregions with the middle frontal gyrus (MFG)/superior frontal gyrus (SFG) was correlated with consummatory anhedonia, and the rsFC of the Nac core-like subdivisions with the inferior frontal gyrus (IFG)/insula and lingual gyrus/visual association cortex was correlated with anticipatory anhedonia. More importantly, the functional alterations in the Nac subregions mediated the association between anhedonia and depression. Conclusions The present findings suggest that the functional alteration of the Nac subregions mediates the association between MDD and anhedonia, which provides evidence for the hypothesis that MDD patients have neurobiological underpinnings of reward systems that differ from those of HCs.

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“…This explains the abnormalities of emotional control [45] and hearing impairment [46] seen in patients with MDD. In addition, analysis of dynamic brain graphs generated by BDANet showed that TE1m had the most significant ab- normalities in functional connectivity with other brain regions, possibly related to anhedonia in MDD [47], which are a core symptom of MDD [48]. The degree of abnormal functional connectivity of p24, showed a significant correlation with the severity of clinical symptoms of MDD.…”

Section: Discussionmentioning

confidence: 95%

Cross-Domain Identification of Multisite Major Depressive Disorder Using End-to-End Brain Dynamic Attention Network

Yuan,

Chen,

Ding

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Objectives: Establishing objective and quantitative imaging markers at individual level can assist in accurate diagnosis of Major Depressive Disorder (MDD). However, the clinical heterogeneity of MDD and the shift to multisite data decreased identification accuracy. To address these issues, the Brain Dynamic Attention Network (BDANet) is innovatively proposed, and analyzed bimodal scans from 2055 participants of the Rest-meta-MDD consortium. Methods: The end-to-end BDANet contains two crucial components. The Dynamic BrainGraph Generator dynamically focuses and represents topological relationships between Regions of Interest, overcoming limitations of static methods. The Ensemble Classifier is constructed to obfuscate domain sources to achieve inter-domain alignment. Finally, BDANet dynamically generates sample-specific brain graphs by downstream recognition tasks. Results: The proposed BDANet achieved an accuracy of 81.6%. The regions with high attribution for classification were mainly located in the insula, cingulate cortex and auditory cortex. The level of brain connectivity in p24 region was negatively correlated (p<0.05) with the severity of MDD. Additionally, sex differences in connectivity strength were observed in specific brain regions and functional subnetworks (p<0.05 or p<0.01). Conclusions and Significance: These findings based on a large multisite dataset support the conclusion that BDANet can better solve the problem of the clinical heterogeneity of MDD and the shift of multisite data. It also illustrates the potential utility of BDANet for personalized accurate identification, treatment and intervention of MDD.

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Aberrant interhemispheric functional connectivity in major depressive disorder with and without anhedonia

Cited by 19 publications

References 55 publications

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder

Cross-Domain Identification of Multisite Major Depressive Disorder Using End-to-End Brain Dynamic Attention Network

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