Aberrant intrinsic functional connectivity in thalamo‐cortical networks in major depressive disorder

Kong, Qingmei; Qiao, Hong; Liu, Chao‐Zhong; Zhang, Ping; Li, Ké; Wang, Li; Li, Jitao; Su, Yun-Ai; Li, Ke‐Qing; Yan, Chao‐Gan; Mitchell, Philip B.; Si, Tianmei

doi:10.1111/cns.12831

Cited by 43 publications

(28 citation statements)

References 58 publications

(129 reference statements)

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“…The rs-FC between the thalamus and the whole brain has been previously examined, and there were relatively consistent findings. MDD subjects had altered thalamocortical connectivity characterized by an intricate pattern in the region that was associated with clinical symptoms; indeed, one of them indicated the thalamus is hyper-connected with SI [ 47 – 50 ]. The importance of the SI has been gradually discovered in schizophrenia patients.…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study

et al. 2018

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BackgroundStudies have confirmed that the thalamus and the primary somatosensory cortex (SI) are associated with cognitive function. These two brain regions are closely related in structure and function. The interactions between SI and the thalamus are of crucial significance for the cognitive process. Patients with major depressive disorder (MDD) have significant cognitive impairment. Based on these observations, we used resting-state functional magnetic resonance imaging (rs-fMRI) to investigate whether there is an abnormality in the SI-thalamic functional connection in MDD. Furthermore, we explored the clinical symptoms related to this abnormality.MethodsWe included 31 patients with first-episode major depressive disorder and 28 age-, gender-, and education-matched healthy controls (HC). The SI-thalamic functional connectivity was compared between the MDD and HC groups. The correlation analyses were performed between areas with abnormal connectivity and clinical characteristics.ResultsCompared with healthy subjects, the MDD patients had enhanced functional connectivity between the thalamus and SI (p < 0.05, corrected). Brain areas with significantly different levels of connectivity had a negative correlation with the Assessment of Neuropsychological Status total score (r = − 0.383, p = 0.033), delayed memory score (r = − 0.376, p = 0.037) and two-digit continuous operation test score (r = − 0.369, p = 0.041) in MDD patients.ConclusionsThese results demonstrate that SI-thalamic functional connectivity is abnormal and associated with the core clinical symptoms in MDD. The SI-thalamic functional connectivity functions as a neurobiological feature and potential biomarker for MDD.

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Section: Discussionmentioning

confidence: 99%

Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study

et al. 2018

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“…Considering the thalamic heterogeneity and its association with MDD neuropathology,12,15 it is inadequate to examine functional deficits from the perspective of a single region of interest (ROI) in the thalamus. Previous studies divided the thalamus into several parts to examine the functional specialization of different thalamic subregions 14,16. Kong et al16 partitioned the whole cortex into six large areas, namely, the prefrontal, motor, somatosensory, parietal, temporal, and occipital cortex, and used them as seeds to examine functional connectivity patterns with each thalamic voxel.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies divided the thalamus into several parts to examine the functional specialization of different thalamic subregions 14,16. Kong et al16 partitioned the whole cortex into six large areas, namely, the prefrontal, motor, somatosensory, parietal, temporal, and occipital cortex, and used them as seeds to examine functional connectivity patterns with each thalamic voxel. Based on specific connectivity patterns of each cortical subdivision, they identified six thalamic parcellations and then examined their whole-brain connectivity patterns.…”

Section: Introductionmentioning

confidence: 99%

<p>Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder</p>

Xue¹,

Wang²,

Tan³

et al. 2019

NDT

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PurposeEntropy analysis of resting-state functional magnetic resonance imaging (R-fMRI) has recently been adopted to characterize brain temporal dynamics in some neuropsychological or psychiatric diseases. Thalamus-related dysfunction might be a potential trait marker of major depressive disorder (MDD), but the abnormal changes in the thalamus based on R-fMRI are still unclear from the perspective of brain temporal dynamics. The aim of this study was to identify local entropy changes and subregional connectivity patterns of the thalamus in MDD patients.Patients and methodsWe measured the sample entropy of the R-fMRI data from 46 MDD patients and 32 matched healthy controls. We employed the Louvain method for the module detection algorithm to automatically identify a functional parcellation of the thalamus and then examined the whole-brain subregional connectivity patterns.ResultsThe results indicated that the MDD patients had decreased entropy in the bilateral thalami compared with healthy controls. Increased functional connectivity between the thalamic subregions and the medial part of the superior frontal gyrus (mSFG) was found in MDD patients.ConclusionThis study showed new evidence about sample entropy changes in MDD patients. The functional connectivity alterations that were widely distributed across almost all the thalamic subregions with the mSFG in MDD suggest a general involvement independent of the location and function of the subregions.

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“…According to the Harvard Oxford subcortical structural atlases ( 25 , 36 ), the thalamus can be subdivided into 7 bilateral subregions based on previous study ( 25 ). Based on previous studies ( 37 , 38 ), we hypothesized that enhanced thalamo-cortical FC would exist in SD, and we also examined whether FC changes was positively correlated with cognitive function and personality traits in patients with SD.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Connectivity of Thalamo-Cortical Networks in First-Episode, Treatment-Naive Somatization Disorder

Zhao

Liu

et al. 2020

Front. Psychiatry

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Background Dysfunctions of the thalamus and its projections to cortical cortices have been implicated in patient with somatization disorder (SD). However, changes in the anatomical specificity of thalamo-cortical functional connectivity (FC) in SD remain unclear. Methods Resting-state fMRI scans were collected in 25 first-episode, drug-naive patients with SD, as well as 28 sex-, age-, and education-matched healthy controls. We parcellated the thalamus with seven predefined regions of interest (ROIs) and used them as seeds to map whole-brain FC. Correlation analysis was conducted in the patients. Results We found an increased pattern of thalamic ROI-cortex connectivity in patients with SD. Patients with SD demonstrated enhanced thalamic connectivity to the bilateral anterior/middle cingulum, motor/sensory cortex, visual cortex, and auditory cortex. A significantly negative correlation was found between the right occipital thalamic ROI to the anterior cingulum and EPQ extraversion scores ( r =0.404, p =0.045) after the Benjamini-Hochberg correction. Conclusions This study demonstrates that anatomical specificity of enhanced thalamo-cortical FCs exists in first-episode, drug-naive patients with SD. These findings further highlight the importance of the thalamic subregions in the pathophysiology of SD.

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Aberrant intrinsic functional connectivity in thalamo‐cortical networks in major depressive disorder

Cited by 43 publications

References 58 publications

Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study

Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study

<p>Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder</p>

Enhanced Connectivity of Thalamo-Cortical Networks in First-Episode, Treatment-Naive Somatization Disorder

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