Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer

Wu, Cheng‐Kun; Wei, Kuo‐Liang; Chou, Jian–Liang; Lu, Chung‐Kuang; Hsieh, Ching‐Chuan; Lin, Jora M. J.; Deng, Yi-Fang; Hsu, Wan‐Ting; Wang, Hui‐Min David; Leung, Chi Hung; Ma, Dik‐Lung; Li, Chin; Chan, Michael W.Y.

doi:10.3390/ijms17091467

Cited by 28 publications

(27 citation statements)

References 22 publications

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“…60 Abnormal JAK/STAT signaling may be involved in epigenetic inhibition of GATA6 expression by promoter hypermethylation, which may further cause downregulation of trefoil factors 1 and 2 (TFF1/2) in GC. 61 In summary, GATA6 has multiple roles in the development of GC, and its gene amplification can be a high-risk factor for the development of GC. Enhancing the expression of GATA6 can also inhibit tumor migration and invasion through certain signaling pathways.…”

Section: Gata6 and Gastric Cancermentioning

confidence: 99%

“…In addition, activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) (JAK/STAT) signal plays a key role in GC development . Abnormal JAK/STAT signaling may be involved in epigenetic inhibition of GATA6 expression by promoter hypermethylation, which may further cause downregulation of trefoil factors 1 and 2 (TFF1/2) in GC …”

Section: Gata6 and Human Cancersmentioning

confidence: 99%

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Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers

Sun

Yan

2019

Clinical Genetics

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Cancer is a common type of non-communicable disease, and its morbidity and mortality are rapidly increasing. It is expected to become the largest obstacle to the promotion of global human health in the future. Some transcription factors that play important regulatory roles in embryogenesis and subsequent tissue maintenance can be selectively amplified during tumorigenesis. Due to its high expression in the embryonic endoderm and mesoderm, GATA6 plays a crucial role in the normal development of early human heart, lung, digestive system, adrenal glands, breasts, ovaries, retina, skin, and nervous system. Up to now, overexpression of the GATA6 gene has been shown to play an important role in several cancers, including lung cancer, digestive system tumors, breast cancer, and ovarian cancer. However, the human body is a complex organism, which causes the transcription factor GATA6 to have multiple roles in cancer. In this review, we summarize the multiple roles of transcription factor GATA6 in various cancers and its regulatory mechanisms. The aim is to better understand the relationship between GATA6 gene expression and cancer development and to provide new insights for exploring potential therapeutic targets.

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Section: Gata6 and Gastric Cancermentioning

confidence: 99%

Section: Gata6 and Human Cancersmentioning

confidence: 99%

Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers

Sun

Yan

2019

Clinical Genetics

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“…In addition, TFF2 and SST have been reported as tumor suppressors, and low level of TFF2 and SST were found in GC patients (66)(67)(68). TFF2 is a short peptide that secreted by gastric mucous neck cells and is helpful for cellular protection of gastrointestinal tract (69).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis and Identification of Potential Biomarkers in Gastric Cancer

Yang¹,

Peng²,

Qin³

et al. 2020

Preprint

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Background: Although the morbidity and mortality of gastric cancer are declining, gastric cancer is still one of the most common causes of death. Early detection of gastric cancer is of great help to improve the survival rate, but the existing biomarkers are not sensitive to diagnose early gastric cancer. The aim of this study is to identify the novel biomarkers for gastric cancer.Methods: Three gene expression profiles (GSE27342, GSE63089, GSE33335) were downloaded from Gene Expression Omnibus database to select differentially expressed genes. Then, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis were performed to explore the biological functions of differentially expressed genes. Cytoscape was utilized to construct protein-protein interaction network and hub genes were analyzed by plugin cytoHubba of Cytoscape. Furthermore, Gene Expression Profiling Interactive Analysis and Kaplan-Meier plotter were used to verify the identified hub genes.Results: 35 overlapping differentially expressed genes were screened from gene expression datasets, which consisted of 11 up-regulated genes and 24 down-regulated genes. Gene Ontology functional enrichment analysis revealed that differentially expressed genes were significantly enriched in digestion, regulation of biological quality, response to hormone and steroid hormone, and homeostatic process. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed differentially expressed genes were enriched in the secretion of gastric acid and collecting duct acid, leukocyte transendothelial migration and ECM-receptor interaction. According to protein-protein interaction network, 10 hub genes were identified by Maximal Clique Centrality method.Conclusion: By using bioinformatics analysis, COL1A1, BGN, THY1, TFF2 and SST were identified as the potential biomarkers for early detection of gastric cancer.

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“…The sediment was washed with 1 mL of ethanol solution 75% (v/v) and centrifuged at 12 000× g for 5 min. Finally, the RNA pellet was dried and dissolved in the buffer solution, treated with 50 μL diethyl pyrocarbonate (DEPC) …”

Section: Methodsmentioning

confidence: 99%

Reversing UVB‐induced photoaging with Hibiscus sabdariffa calyx aqueous extract

Lin

et al. 2019

J Sci Food Agric

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BACKGROUND Hibiscus sabdariffa is commonly used in daily life and its extract is applied widely in food and cosmetics. However, it has not been evaluated for its anti‐aging effects. RESULTS Hibiscus sabdariffa calyx aqueous extract (HSCAE) has shown potential collagenase activity suppression effects, together with tyrosinase activity inhibition, and anti‐oxidation as a free radical scavenger. The current investigation demonstrated that HSCAE was not cytotoxic in skin fibroblasts, and it significantly decreased ultraviolet B (UVB)‐induced reactive oxygen species (ROS) on a flow cytometry assay. Moreover, HSCAE reduced matrix metalloproteinase (MMP) expression, increased tissue inhibition of metalloproteinase (TIMP)‐1 level, and enhanced collagen content by inhibiting collagenase activity. It also blocked mRNA and protein expressions of melanin production pathway key factors, including the microphthalmia‐associated transcription factor (MITF), tyrosinase, tyrosinase‐related protein‐1 (TRP‐1), and dopachrome tautomerase‐2 (TRP‐2). CONCLUSION These results demonstrated, for the first time, the potential of HSCAE as a natural antioxidant with the ability to maintain collagen production and to decrease melanin syntheses under UVB radiation, for anti‐aging effects. © 2019 Society of Chemical Industry

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Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer

Cited by 28 publications

References 22 publications

Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers

Multiple roles and regulatory mechanisms of the transcription factor GATA6 in human cancers

Bioinformatics Analysis and Identification of Potential Biomarkers in Gastric Cancer

Reversing UVB‐induced photoaging with Hibiscus sabdariffa calyx aqueous extract

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