2020
DOI: 10.1177/2058738420974888
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Aberrant miR-219-5p is correlated with TLR4 and serves as a novel biomarker in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning

Abstract: This study aimed to investigate the clinical significance of serum microRNA-219-5p (miR-219-5p) in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat (PQ) poisoning, and its correlation with Toll-like Receptor 4 (TLR4). Luciferase reporter assay was used to investigate in vitro the correlation of miR-219-5p with TLR4. Serum miR-219-5p levels were evaluated by quantitative real-time polymerase chain reaction. Serum levels of TLR4, IL-1β, and TNF-α were measured by Enzyme-linked im… Show more

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Cited by 4 publications
(5 citation statements)
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“…miRNAs used as biomarkers for organ damage have been reported. 23,24 Notably, miR-219-5p 7 and miR-27a 6 can be used as biomarkers for the diagnosis and survival prognosis of MODS patients induced by paraquat. In this study, we further investigated the clinical value of miR-200b-3p in patients with MODS caused by paraquat poisoning.…”
Section: Discussionmentioning
confidence: 99%
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“…miRNAs used as biomarkers for organ damage have been reported. 23,24 Notably, miR-219-5p 7 and miR-27a 6 can be used as biomarkers for the diagnosis and survival prognosis of MODS patients induced by paraquat. In this study, we further investigated the clinical value of miR-200b-3p in patients with MODS caused by paraquat poisoning.…”
Section: Discussionmentioning
confidence: 99%
“…6 miR-219-5p may participant in MODS process by regulating inflammatory responses via affecting toll-like receptor 4 (TLR4). 7…”
Section: Introductionmentioning
confidence: 99%
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“…Tus, the early prediction of the severity of acute PQ poisoning can aid the guidance of appropriate treatment. Current studies on the prognosis of paraquat poisoning mainly include the amount of paraquat ingested [7], hematological indicators [8][9][10], biological indicators [11][12][13], various rating scales [14,15], and ultrasound and imaging indicators [16,17]. However, no unifed clinical standards are present for prognostic evaluation of PQ poisoning to date.…”
Section: Introductionmentioning
confidence: 99%