Aberrant mitochondrial DNA methylation and declined pulmonary function in a population with polycyclic aromatic hydrocarbon composition in particulate matter

Guo, Liqiong; Wang, Yanhua; Yang, Xueli; Wang, Ting; Yin, Jie; Zhao, Liwei; Lin, Yang; Dai, Yufei; Hou, Shike; Duan, Huawei

doi:10.1016/j.envres.2022.113797

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…They describe 13,643 differentially methylated CpG loci between policeman from two different cities; they also found two hypomethylated loci annotated to the DNA repair gene XRCC5 ; groups of differentially methylated loci annotated to the same gene were linked to diabetes mellitus, respiratory diseases, the dopaminergic system of the brain and neurodegenerative diseases. Finally, Guo et al ( 57 ), investigated mitochondrial DNA (mtDNA) methylation in workers from a coke-oven plant exposed concurrently to PAH's and PM 2.5 mtDNA methylation was measured by bisulfite pyrosequencing of two genes of ATP synthase ( MT-ATP6 and MT-ATP8 ). They observed a significant, negative association between methylation of platelet mitochondrial gene MT-ATP6 and PM exposure.…”

Section: Resultsmentioning

confidence: 99%

Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents

Jiménez-Garza

Ghosh

Barrow

et al. 2023

Front. Public Health

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IntroductionEpigenetic marks have been proposed as early changes, at the subcellular level, in disease development. To find more specific biomarkers of effect in occupational exposures to toxicants, DNA methylation studies in peripheral blood cells have been performed. The goal of this review is to summarize and contrast findings about DNA methylation in blood cells from workers exposed to toxicants.MethodsA literature search was performed using PubMed and Web of Science. After first screening, we discarded all studies performed in vitro and in experimental animals, as well as those performed in other cell types other than peripheral blood cells. Results: 116 original research papers met the established criteria, published from 2007 to 2022. The most frequent investigated exposures/labor group were for benzene (18.9%) polycyclic aromatic hydrocarbons (15.5%), particulate matter (10.3%), lead (8.6%), pesticides (7.7%), radiation (4.3%), volatile organic compound mixtures (4.3%), welding fumes (3.4%) chromium (2.5%), toluene (2.5%), firefighters (2.5%), coal (1.7%), hairdressers (1.7%), nanoparticles (1.7%), vinyl chloride (1.7%), and others. Few longitudinal studies have been performed, as well as few of them have explored mitochondrial DNA methylation. Methylation platforms have evolved from analysis in repetitive elements (global methylation), gene-specific promoter methylation, to epigenome-wide studies. The most reported observations were global hypomethylation as well as promoter hypermethylation in exposed groups compared to controls, while methylation at DNA repair/oncogenes genes were the most studied; studies from genome-wide studies detect differentially methylated regions, which could be either hypo or hypermethylated.DiscussionSome evidence from longitudinal studies suggest that modifications observed in cross-sectional designs may be transitory; then, we cannot say that DNA methylation changes are predictive of disease development due to those exposures.ConclusionDue to the heterogeneity in the genes studied, and scarcity of longitudinal studies, we are far away from considering DNA methylation changes as biomarkers of effect in occupational exposures, and nor can we establish a clear functional or pathological correlate for those epigenetic modifications associated with the studied exposures.

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Section: Resultsmentioning

confidence: 99%

Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents

Jiménez-Garza

Ghosh

Barrow

et al. 2023

Front. Public Health

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“… 65 FEV1/FVC is also decreased by exposure to PAH-enriched PM2.5. 66 Nevertheless, the exact mechanism is still unknown. The well-known PAH can result in lung cancer by elevating the expression of the CYP1A1 gene and promoting DNA damage.…”

Section: Pm25 Components and Copdmentioning

confidence: 99%

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

Wang¹,

Li²

2023

COPD

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Chronic obstructive pulmonary disease (COPD), a heterogeneous disease, is the leading cause of death worldwide. In recent years, air pollution, especially particulate matter (PM), has been widely studied as a contributing factor to COPD. As an essential component of PM, PM2.5 is associated with COPD prevalence, morbidity, and acute exacerbations. However, the specific pathogenic mechanisms were still unclear and deserve further research. The diversity and complexity of PM2.5 components make it challenging to get its accurate effects and mechanisms for COPD. It has been determined that the most toxic PM2.5 components are metals, polycyclic aromatic hydrocarbons (PAHs), carbonaceous particles (CPs), and other organic compounds. PM2.5-induced cytokine release and oxidative stress are the main mechanisms reported leading to COPD. Nonnegligibly, the microorganism in PM 2.5 may directly cause mononuclear inflammation or break the microorganism balance contributing to the development and exacerbation of COPD. This review focuses on the pathophysiology and consequences of PM2.5 and its components on COPD.

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“…12 921 brain tissue of CB57BL/6J mice [52]. In studies using patient samples and in vitro cell models, PM induced damaged mitochondrial DNA (mtDNA) and an alteration in fusion-fission dynamics [involving dynamin-related protein 1 (DRP1), mitochondria fission protein 1 (FIS1), and mitofusin 2] [50, 53,54]. Collectively, these observations suggest that chronic PM exposure can gradually lead to metabolic reprogramming, which may promote low-grade chronic inflammation and mitochondrial dysfunction.…”

Section: Trends In Pharmacological Sciencesmentioning

confidence: 99%

Unravelling the signaling power of pollutants

Manzano-Covarrubias,

Yan,

Luu

et al. 2023

Trends in Pharmacological Sciences

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Aberrant mitochondrial DNA methylation and declined pulmonary function in a population with polycyclic aromatic hydrocarbon composition in particulate matter

Cited by 5 publications

References 57 publications

Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents

Toxicomethylomics revisited: A state-of-the-science review about DNA methylation modifications in blood cells from workers exposed to toxic agents

The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease

Unravelling the signaling power of pollutants

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