Aberrant parasympathetic responses in acupuncture therapy for restoring immune homeostasis

Liu, Jing; Dong, Shun; Liu, Shenbin

doi:10.1097/hm9.0000000000000060

Cited by 3 publications

(3 citation statements)

References 78 publications

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“…The ACh then interacts with the α7 nicotinic acetylcholine receptor (α7nAChR) on macrophages and other immune cells to stop the release of pro-inflammatory cytokines, protecting the body from harm [90,91] . The CAP pathway is also known as the cholinergic vagosplenic anti-inflammatory pathway [92] . CAP also refers to the release of ACh from efferent vagal nerve endings, which activates cholinergic receptors on inflammatory cells, effectively inhibiting the release of various inflammatory factors (TNF, IL-1, IL-6, and IL-18) and significantly reducing local and systemic inflammatory response [85] .…”

Section: Effects On Autonomic Pathway Activation Of Cholinergic Anti-...mentioning

confidence: 99%

“…Additionally, body acupuncture therapy for immunological diseases can activate the cholinergic vagal-myenteric plexus system [16,103] . The cholinergic vagal immunomodulation pathway can function directly through post-parasympathetic neurons (the myenteric plexus) found in visceral organs independent of the spleen [92] . Through this cholinergic vagalmyenteric plexus route, it has been demonstrated that EA activation of ST36 can reduce pancreatitis, intestinal ischemia-reperfusion injury, and postoperative ileusinduced inflammatory responses [104][105][106] .…”

Section: Effects On Other Somatosensory Autonomic Pathwaysmentioning

confidence: 99%

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Electroacupuncture targeting the immune system to alleviate sepsis

Fang,

Lan,

et al. 2024

Acupuncture and Herbal Medicine

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Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates. However, options for sepsis are still limited to general treatment in intensive care units (ICUs), and effective therapies that improve sepsis survival are required. Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation, susceptibility to infections, and death. Therefore, many investigators have focused on the potential benefits of immunomodulation therapy for sepsis. Electroacupuncture (EA) has been practiced in clinics for many years and has shown advantages in treating infectious diseases. Over the last few decades, our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments. We searched the literature regarding “CNKI, Wan Fang Data, VIP Database, PubMed, and Ingenta Connect” from 2010 to 2023, using the keywords "sepsis," "septic," and “electroacupuncture” and 336 sources were searched. Finally, we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on sepsis. In this review, we found that EA has clinical benefits in relieving septic inflammation, improving immune function, and attenuating related muti-organ injury through several mechanisms, such as activation of the cholinergic anti-inflammatory pathway (CAP), vagal-adrenal axis, inhibition of the nuclear factor Kappa-B (NF-κB) signaling pathway, signal transducers and activators of transcription (STAT) signaling pathway, and improvement of immune cell function. Therefore, EA may be a promising complementary therapy for sepsis treatment. We also expect these data will contribute to further studies on EA in sepsis.

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Section: Effects On Autonomic Pathway Activation Of Cholinergic Anti-...mentioning

confidence: 99%

Section: Effects On Other Somatosensory Autonomic Pathwaysmentioning

confidence: 99%

Electroacupuncture targeting the immune system to alleviate sepsis

Fang,

Lan,

et al. 2024

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

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“…Some progress has been made in recent years regarding the mechanism of acupuncture for treating sepsis. Acupuncture stimulation can drive various somatosensory-parasympathetic pathways in an acupoint- and intensity- dependent manner [ 7 ]. Studies in 2014 and 2020 have found that the anti-sepsis effect of EA is related to the vagus nerve-adrenal medulla-dopaminergic anti-inflammatory pathway, which explain the neuroendocrine regulation pathway of EA and its anti-inflammatory effects [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture-driven endogenous circulating serum exosomes as a potential therapeutic strategy for sepsis

Zhang,

Wang,

et al. 2023

Chin Med

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Background Sepsis poses a serious threat to human life and health, with limited options for current clinical treatments. Acupuncture plays an active role in treating sepsis. However, previous studies have focused on the neuromodulatory effect of acupuncture, neglecting its network modulatory effect. Exosomes, as a new way of intercellular communication, may play an important role in transmitting acupuncture information. This paper explores the possibility of electroacupuncture-driven endogenous circulating serum exosomes and their carried miRNAs as a potential treatment for sepsis. Methods The sepsis mouse model was established by intraperitoneal injection of lipopolysaccharide (LPS) (12 mg/kg, 24 mg/kg), and EA (continuous wave, 10 Hz, intensity 5) or intraperitoneal injection of Acupuncture Exosomes (Acu-exo) were performed before the model establishment. The therapeutic effect was evaluated by survival rate, ELISA, H&E staining and lung wet/dry weight ration (W/D). In vivo imaging of small animals was used to observe the accumulation of Acu-exo in various organs of sepsis mice. LPS was used to induce macrophages in cell experiments, and the effect of Acu-exo on macrophage inflammatory cytokines was observed. In addition, The miRNA sequencing method was further used to detect the serum exosomes of normal and EA-treated mice, and combined with network biology analysis methods to screen possible key targets. Results EA and Acu-exo reduced the W/D and lung tissue damage in sepsis mice, down-regulated the expression of serum inflammatory cytokines TNF-α and IL-6, and increased the survival rate of sepsis mice. In vivo imaging of small animals found that Acu-exo were accumulated in the lungs of sepsis mice. Cell experiments proved that Acu-exo down-regulated the expression of inflammatory cytokines TNF-α, IL-6 and IL-1β to alleviate the inflammatory response induced by LPS in macrophages. MiRNA sequencing revealed 53 differentially expressed miRNAs, and network biology analysis revealed the key targets of Acu-exo in sepsis treatment. Conclusion Electroacupuncture-driven endogenous circulating serum exosomes and their carried miRNAs may be a potential treatment for sepsis.

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Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure: A Randomized Controlled Trial

Lai,

Liu,

et al. 2024

Chin. J. Integr. Med.

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Aberrant parasympathetic responses in acupuncture therapy for restoring immune homeostasis

Cited by 3 publications

References 78 publications

Electroacupuncture targeting the immune system to alleviate sepsis

Electroacupuncture targeting the immune system to alleviate sepsis

Electroacupuncture-driven endogenous circulating serum exosomes as a potential therapeutic strategy for sepsis

Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure: A Randomized Controlled Trial

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