Aberrant protein synthesis and cancer development: The role of canonical eukaryotic initiation, elongation and termination factors in tumorigenesis

Rubio, Angela; Garland, Gavin D.; Sfakianos, Aristeidis; Harvey, R; Willis, Anne E.

doi:10.1016/j.semcancer.2022.04.006

Cited by 21 publications

(11 citation statements)

References 243 publications

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“…One-third of the metabolites identified belong to the class of amino acids, the building block of proteins. This can be attributed to greater need for protein synthesis, owing to rapid cellular proliferation [ 48 , 49 ]. L-glutamic acid also known as glutamate (6/13 hits) followed by L-methionine (5/13 hits) were the most reported metabolites and amino acids across different studies.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review

Alapati,

Fortuna,

Ramage

et al. 2023

Metabolites

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In recent years, high-throughput technologies have facilitated the widespread use of metabolomics to identify biomarkers and targets for oral squamous cell carcinoma (OSCC). As a result, the primary goal of this systematic review is to identify and evaluate metabolite biomarkers and their pathways for OSCC that featured consistently across studies despite methodological variations. Six electronic databases (Medline, Cochrane, Web of Science, CINAHL, ProQuest, and Embase) were reviewed for the longitudinal studies involving OSCC patients and metabolic marker analysis (in accordance with PRISMA 2020). The studies included ranged from the inception of metabolomics in OSCC (i.e., 1 January 2007) to 30 April 2023. The included studies were then assessed for their quality using the modified version of NIH quality assessment tool and QUADOMICS. Thirteen studies were included after screening 2285 studies. The majority of the studies were from South Asian regions, and metabolites were most frequently derived from saliva. Amino acids accounted for more than quarter of the detected metabolites, with glutamate and methionine being the most prominent. The top dysregulated metabolites indicated dysregulation of six significantly enriched pathways including aminoacyl-tRNA biosynthesis, glutathione metabolism and arginine biosynthesis with the false discovery rate (FDR) <0.05. Finally, this review highlights the potential of metabolomics for early diagnosis and therapeutic targeting of OSCC. However, larger studies and standardized protocols are needed to validate these findings and make them a clinical reality.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review

Alapati,

Fortuna,

Ramage

et al. 2023

Metabolites

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“…In the current study, we analyzed 29 m7G methylation-related genes in LSCC tissues versus normal specimens and identified five m7G methylation-related genes as a risk model to estimate the survival of LSCC patients. Specifically, eukaryotic translation initiation factor 3 (EIF3) is necessary for the initiation of protein synthesis in cells and consists of subunits of EIF3A-M; if its subunits are altered, oncogene expression is upregulated, and tumor transformation occurs ( 39 - 41 ). For example, EIF3D , as the core subunit of EIF3, plays an oncogenic role in NSCLC ( 42 ), and the percentage of apoptotic cells in renal cell carcinoma cells was increased after knockdown of EIF3D expression ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

A signature of five 7-methylguanosine-related genes is a prognostic marker for lung squamous cell carcinoma

Liu,

Wang,

Ulivi

et al. 2023

J Thorac Dis

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Background N 7 -methylguanosine (m7G) is an important posttranscriptional modification affecting mRNA and tRNA functions and stability. The genes regulating the m7G process have been previously found involved in the carcinogenesis process. We aimed to analyze the role of m7G-related genes as potential prognostic markers for lung squamous cell carcinoma (LSCC). Methods Twenty-nine m7G-related genes were selected for the analysis in the LSCC cohort of the Cancer Genome Atlas (TCGA). Univariate, multivariate, and Kaplan-Meier analyses were used to evaluate the predictive value of risk model developed with m7G signature for overall survival (OS).. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of differentially expressed genes (DEGs) were performed for high- and low-risk LSCC groups. Results We identified 17 differentially expressed m7G methylation-related genes in LSCC versus normal tissues. The expression of five m7G-related genes ( EIF3D , LSM1 , NCBP2 , NUDT10 , and NUDT11 ) was identified as an independent prognostic marker for OS in LSCC patients. A risk model with these five m7G-related genes predicted 2-, and 3-year survival rates of 0.623 and 0.626, respectively. The risk score significantly correlated with OS: LSCC patients with a higher risk score had shorter OS (P<0.01) and it was associated with lower immune response (P<0.01). Conclusions We developed a novel m7G-related gene signature that can be of great utility to predict the prognosis for patients with LSCC.

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“…Dysregulation of mRNA translation is a prominent feature of cancer, leading to the excessive synthesis of oncogenic proteins involved in various oncogenic processes 183–185 . Cancer cells often exhibit altered mechanisms of translational control, enabling increased production of proteins that promote tumor growth, survival, angiogenesis, and metastasis 186–189 . Recent studies have highlighted the role of the METTL1/WDR4 complex in elevated mRNA translation and enhanced tRNA stability, which contributes to the development of several cancers.…”

Section: Rna Methylation and Rna Metabolismmentioning

confidence: 99%

“… 183 , 184 , 185 Cancer cells often exhibit altered mechanisms of translational control, enabling increased production of proteins that promote tumor growth, survival, angiogenesis, and metastasis. 186 , 187 , 188 , 189 Recent studies have highlighted the role of the METTL1/WDR4 complex in elevated mRNA translation and enhanced tRNA stability, which contributes to the development of several cancers. Notably, the upregulated expression of the METTL1/WDR4 complex has been found to drive translational regulation of specific oncogenic mRNAs in HCC through m 7 G tRNA modification‐dependent mechanisms, thereby fueling hepatocarcinogenesis.…”

Section: Rna Methylation and Rna Metabolismmentioning

confidence: 99%

Critical roles and clinical perspectives of RNA methylation in cancer

Li,

Yao,

Liu

et al. 2024

MedComm

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RNA modification, especially RNA methylation, is a critical posttranscriptional process influencing cellular functions and disease progression, accounting for over 60% of all RNA modifications. It plays a significant role in RNA metabolism, affecting RNA processing, stability, and translation, thereby modulating gene expression and cell functions essential for proliferation, survival, and metastasis. Increasing studies have revealed the disruption in RNA metabolism mediated by RNA methylation has been implicated in various aspects of cancer progression, particularly in metabolic reprogramming and immunity. This disruption of RNA methylation has profound implications for tumor growth, metastasis, and therapy response. Herein, we elucidate the fundamental characteristics of RNA methylation and their impact on RNA metabolism and gene expression. We highlight the intricate relationship between RNA methylation, cancer metabolic reprogramming, and immunity, using the well‐characterized phenomenon of cancer metabolic reprogramming as a framework to discuss RNA methylation's specific roles and mechanisms in cancer progression. Furthermore, we explore the potential of targeting RNA methylation regulators as a novel approach for cancer therapy. By underscoring the complex mechanisms by which RNA methylation contributes to cancer progression, this review provides a foundation for developing new prognostic markers and therapeutic strategies aimed at modulating RNA methylation in cancer treatment.

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Aberrant protein synthesis and cancer development: The role of canonical eukaryotic initiation, elongation and termination factors in tumorigenesis

Cited by 21 publications

References 243 publications

Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review

Evaluation of Metabolomics as Diagnostic Targets in Oral Squamous Cell Carcinoma: A Systematic Review

A signature of five 7-methylguanosine-related genes is a prognostic marker for lung squamous cell carcinoma

Critical roles and clinical perspectives of RNA methylation in cancer

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