Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer

Qi, Lin; Li, Jun; Zhu, Dexiang; Niu, Zhihong; Pan, Xue; Xu, Pingping; Ji, Meiling; Ye, Wei; Xu, Jianmin

doi:10.3389/fphar.2019.01183

Cited by 16 publications

(15 citation statements)

References 43 publications

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“…Gelsolin has been found to regulate EMT in HPV cells, predict patient prognosis in squamous cell carcinoma of the larynx, and suppress apoptotic machinery in neuroendocrine prostate cancer [42,43]. Adseverin expression has been reported to be a marker for cisplatin resistance in bladder cancer and correlate with prognosis in colorectal cancer [44,45]. Calcium signaling is disrupted in GBM, and may provide an abundant source for gelsolin family member activation [46].…”

Section: Advillin Family Members and Their Association With Cancermentioning

confidence: 99%

Targeting AVIL, a New Cytoskeleton Regulator in Glioblastoma

Cornelison

Marrah

Horter

et al. 2021

IJMS

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Glioblastoma (GBM) is the most common adult neural malignancy and the deadliest. The standard of care is optimal, safe, cytoreductive surgery followed by combined radiation therapy and alkylating chemotherapy with temozolomide. Recurrence is common and therapeutic options in the recurrent setting are limited. The dismal prognosis of GBM has led to novel treatments being a serious roadblock in the field, with most new treatments failing to show efficacy. Targeted therapies have shown some success in many cancers, but GBM remains one of the most difficult to treat, especially in recurrence. New chemotherapeutic directions need to be explored, possibly expanding the targeted chemotherapy spectrum in previously unforeseen ways. In this perspective paper, we will explain why AVIL, an actin-binding protein recently found to be overexpressed in GBM and a driving force for GBM, could prove versatile in the fight against cancer. By looking at AVIL and its potential to regulate FOXM1 and LIN28B, we will be able to highlight a way to improve outcomes for GBM patients who normally have very little hope.

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Section: Advillin Family Members and Their Association With Cancermentioning

confidence: 99%

Targeting AVIL, a New Cytoskeleton Regulator in Glioblastoma

Cornelison

Marrah

Horter

et al. 2021

IJMS

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“…In this context, serpinA1 may be a potential therapeutic target for novel predictive biomarkers and CRC. Scinderin (SCIN) may be a significant predictor of poor prognosis in patients with CRC liver metastasis (CRLM) and CRC [ 53 ]. Our research provided new insights into the genes highly expressed in CRC, which may help explain the dual role of Th17 cells.…”

Section: Discussionmentioning

confidence: 99%

Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Zhou

et al. 2021

Bioscience Reports

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Background: Colorectal cancer (CRC) is the most common type of gastrointestinal malignant tumour. Colorectal adenocarcinoma (COAD) – the most common type of CRC – is particularly dangerous. The role of the immune system in the development of tumour-associated inflammation and cancer has received increasing attention recently. Methods: In the present study, we compiled the expression profiles of 262 patients with complete follow-up data from The Cancer Genome Atlas (TCGA) database as an experimental group and selected 65 samples from the Gene Expression Omnibus (GEO) dataset (of which 46 samples were with M0) as a verification group. First, we screened the immune T helper 17 (Th17) cells related to the prognosis of COAD. Subsequently, we identified Th17 cells-related hub genes by utilising Weighted Gene Co-expression Network Analysis (WGCNA) and Least Absolute Shrinkage and Selector Operation (LASSO) regression analysis. Six genes associated with the prognosis in patients with COAD were identified, including: KRT23, ULBP2, ASRGL1, SERPINA1, SCIN, and SLC28A2. We constructed a clinical prediction model and analysed its predictive power. Results: The identified hub genes are involved in developing many diseases and closely linked to digestive disorders. Our results suggested that the hub genes could influence the prognosis of COAD by regulating Th17 cells’ infiltration. Conclusions: These newly discovered hub genes contribute to clarifying the mechanisms of COAD development and metastasis. Given that they promote COAD development, they may become new therapeutic targets and biomarkers of COAD.

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“…Some studies have found that SCIN is highly expressed in human prostate cancer specimens and human lung cancer tissues and plays an important role in cell proliferation (Liu et al, 2015; Wang et al, 2014). In colorectal cancer, the expression of SCIN is increased and is closely related to poor prognosis (Lin, Li, et al, 2019). Therefore, it may be a potential therapeutic target in colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Gene expression network related to DNA methylation and miRNA regulation during the process of aflatoxin B1‐induced malignant transformation of L02 cells

Zhao

Chen

Yang

et al. 2021

J of Applied Toxicology

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Aflatoxin is a secondary metabolite secreted by Aspergillus flavus, parasitic Aspergillus, and other fungi through the polyketone pathway, and it can be detected in many foods. Aflatoxin has strong toxicity and carcinogenicity, and many studies have shown that aflatoxin is highly associated with liver cancer. In the present study, malignant transformation of L02 cells was induced by aflatoxin B1 (AFB1), and the gene expression, miRNA expression, and methylation level were detected by high‐throughput sequencing. The gene and miRNA expression results showed that 2547 genes and 315 miRNAs were changed in the AFB1‐treated group compared with the DMSO group. Among them, RSAD2 and SCIN were significantly upregulated, whereas TRAPPC3L and UBE2L6 were significantly downregulated. Has‐miR‐33b‐3p was significantly upregulated, whereas Has‐miR‐3613‐5p was significantly downregulated. The methylation results showed that 2832 CpG sites were methylated on the promoter or coding DNA sequence (CDS) of the gene, whereas the expression of DNMT3a and DNMT3b was significantly upregulated. Moreover, hypermethylation occurred in TRAPPC3L, CDH13, and SPINK13. The results of GO and KEGG pathway analyses showed that significantly changed genes and miRNAs were mainly involved in tumor formation, proliferation, invasion, and migration. The results of network map analysis showed that Hsa‐miR‐3613‐5p, Hsa‐miR‐615‐5p, Hsa‐miR‐615‐3p, and Hsa‐miR‐3158‐3p were the key miRNAs for malignant transformation of L02 cells induced by AFB1. In addition, the expression of ONECUT2, RAP1GAP2, and FSTL4 was regulated by DNA methylation and miRNAs. These results suggested that the gene expression network regulated by DNA methylation and miRNAs may play a vital role in AFB1‐induced hepatocellular carcinoma.

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Aberrant Scinderin Expression Correlates With Liver Metastasis and Poor Prognosis in Colorectal Cancer

Cited by 16 publications

References 43 publications

Targeting AVIL, a New Cytoskeleton Regulator in Glioblastoma

Targeting AVIL, a New Cytoskeleton Regulator in Glioblastoma

Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers

Gene expression network related to DNA methylation and miRNA regulation during the process of aflatoxin B1‐induced malignant transformation of L02 cells

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