Aberrant Sensory Innervation of the Olfactory Bulb in Neuropilin-2 Mutant Mice

Walz, Andreas; Rodríguez, Iván; Mombaerts, Peter

doi:10.1523/jneurosci.22-10-04025.2002

Cited by 172 publications

(170 citation statements)

References 52 publications

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“…Members of the secreted semaphorin (Sema) family and their receptors, the neuropilins, have been implicated in the development of OSN projections. (de Castro et al, 1999;Pasterkamp et al, 1999;Renzi et al, 2000;Schwarting et al, 2000;Walz et al, 2002;Cloutier et al, 2004;Schwarting et al, 2004). Indeed, Sema3A is required for appropriate medial to lateral targeting of OSN axons (Schwarting et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Requirement for Slit-1 and Robo-2 in Zonal Segregation of Olfactory Sensory Neuron Axons in the Main Olfactory Bulb

Cho¹,

Lépine²,

Andrews³

et al. 2007

J. Neurosci.

112

125

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The formation of precise stereotypic connections in sensory systems is critical for the ability to detect and process signals from the environment. In the olfactory system, olfactory sensory neurons (OSNs) project axons to spatially defined glomeruli within the olfactory bulb (OB). A spatial relationship exists between the location of OSNs within the olfactory epithelium (OE) and their glomerular targets along the dorsoventral axis in the OB. The molecular mechanisms underlying the zonal segregation of OSN axons along the dorsoventral axis of the OB are poorly understood. Using robo-2 Ϫ/Ϫ (roundabout) and slit-1 Ϫ/Ϫ mice, we examined the role of the Slit family of axon guidance cues in the targeting of OSN axons during development. We show that a subset of OSN axons that normally project to the dorsal region of the OB mistarget and form glomeruli in the ventral region in robo-2 Ϫ/Ϫ and slit-1 Ϫ/Ϫ mice. In addition, we show that the Slit receptor, Robo-2, is expressed in OSNs in a high dorsomedial to low ventrolateral gradient across the OE and that Slit-1 and Slit-3 are expressed in the ventral region of the OB. These results indicate that the dorsal-to-ventral segregation of OSN axons are not solely defined by the location of OSNs within the OE but also relies on axon guidance cues.

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Section: Introductionmentioning

confidence: 99%

Requirement for Slit-1 and Robo-2 in Zonal Segregation of Olfactory Sensory Neuron Axons in the Main Olfactory Bulb

Cho¹,

Lépine²,

Andrews³

et al. 2007

J. Neurosci.

112

125

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“…There are five other members of the class 3 family of semaphorins (Semaphorin Nomenclature Committee, 1999). Between them, they regulate the formation of neuronal networks in many regions of the CNS, including the hippocampus, cerebral cortex, and olfactory system (Chedotal et al, 1998;Polleux et al, 1998;Schwarting et al, 2000;Pozas et al, 2001;Cloutier et al, 2002;Walz et al, 2002;Taniguchi et al, 2003). In addition to directing growth cone movements, they regulate the migration of cells, including neural crest and neuronal progenitor cells (Song et al, 1998;Eickholt et al, 1999;Bagnard et al, 2001;Kawasaki et al, 2002) and, thus, may play a role in shaping anatomic structures.…”

Section: Introductionmentioning

confidence: 99%

Cranial expression of class 3 secreted semaphorins and their neuropilin receptors

Chilton

Guthrie

2003

Developmental Dynamics

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The semaphorin family of chemorepellents and their receptors the neuropilins are implicated in a variety of cellular processes, including axon guidance and cell migration. Semaphorins may bind more than one neuropilin or a heterodimer of both, thus a detailed knowledge of their expression patterns may reveal possible cases of redundancy or mutual antagonism. To assess their involvement in cranial development, we cloned fragments of the chick orthologues of Sema3B and Sema3F. We then carried out mRNA in situ hybridisation of all six class 3 semaphorins and both neuropilins in the embryonic chick head. We present evidence for spatiotemporal regulation of these molecules in the brainstem and developing head, including the eye, ear, and branchial arches. These expression patterns provide a basis for functional analysis of semaphorins and neuropilins in the development of axon projections and the morphogenesis of cranial structures. Developmental Dynamics 228:726 -733, 2003.

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“…The screening of molecules that were up-regulated in the CMS-induced cells, and down-regulated in the CMS-inhibited cells, revealed Nrp2 as a candidate. Interestingly, analysis of the heterozygous Nrp2-Δ mouse brain ( +/− ), in which tauGFP was knocked in into the Nrp2 locus (19), revealed that the pattern of Nrp2 expression was similar to that of COUP-TFII (Fig. 6).…”

Section: Nrp2 Is Preferentially Expressed In the Cms And Functions As Amentioning

confidence: 97%

The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

Kanatani

Honda

Aramaki

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The preoptic area (POa) of the rostral diencephalon supplies the neocortex and the amygdala with GABAergic neurons in the developing mouse brain. However, the molecular mechanisms that determine the pathway and destinations of POa-derived neurons have not yet been identified. Here we show that Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2) and its down-regulation control the destination of POa-derived GABAergic neurons. Initially, a majority of the POa-derived migrating neurons express COUP-TFII and form a caudal migratory stream toward the caudal subpallium. When a subpopulation of cells steers toward the neocortex, they exhibit decreased expression of COUP-TFII and Nrp2. The present findings show that suppression of COUP-TFII/Nrp2 changed the destination of the cells into the neocortex, whereas overexpression of COUP-TFII/Nrp2 caused cells to end up in the medial part of the amygdala. Taken together, these results reveal that COUP-TFII/Nrp2 is a molecular switch determining the pathway and destination of migrating GABAergic neurons born in the POa.

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Aberrant Sensory Innervation of the Olfactory Bulb in Neuropilin-2 Mutant Mice

Cited by 172 publications

References 52 publications

Requirement for Slit-1 and Robo-2 in Zonal Segregation of Olfactory Sensory Neuron Axons in the Main Olfactory Bulb

Requirement for Slit-1 and Robo-2 in Zonal Segregation of Olfactory Sensory Neuron Axons in the Main Olfactory Bulb

Cranial expression of class 3 secreted semaphorins and their neuropilin receptors

The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

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