Aberrant white matter microstructure evaluation by automated fiber quantification in typhoon-related post-traumatic stress disorder

Zhang, Yiying; Chen, Huijuan; Qi, Rongfeng; Ke, Jun; Xu, Qiang; Zhong, Yuan; Wu, Yanglei; Guo, Yihao; Lu, Guangming; Chen, Feng

doi:10.1007/s11682-022-00755-1

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…While findings are somehow inconsistent [44,45], the uncinate fasciculus (UF), the cingulum (CI), and the inferior longitudinal fasciculus (ILF) have all been associated with cognitive decline and aging in PTSD, TBI, and AD [34-36, 38, 40, 41, 46-49]. Additionally, the UF and CI were found to be the most important tracts in distinguishing groups with PTSD and trauma-exposed controls [50]. The UF connects the anterior temporal lobe with the lateral orbitofrontal cortex and is involved in emotion and memory regulation [51,52].…”

Section: Introductionmentioning

confidence: 99%

Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans

Marcolini,

Rojczyk,

Seitz-Holland

et al. 2023

JAD

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Background: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans and linked to behavioral disturbances, increased risk of cognitive decline, and Alzheimer’s disease. Objective: We studied the synergistic effects of PTSD and TBI on behavioral, cognitive, and neuroimaging measures in Vietnam war Veterans. Methods: Data were acquired at baseline and after about one-year from male Veterans categorized into: PTSD, TBI, PTSD+TBI, and Veteran controls without PTSD or TBI. We applied manual tractography to examine white matter microstructure of three fiber tracts: uncinate fasciculus (N = 91), cingulum (N = 87), and inferior longitudinal fasciculus (N = 95). ANCOVAs were used to compare Veterans’ baseline behavioral and cognitive functioning (N = 285), white matter microstructure, amyloid-β (N = 230), and tau PET (N = 120). Additional ANCOVAs examined scores’ differences from baseline to follow-up. Results: Veterans with PTSD and PTSD+TBI, but not Veterans with TBI only, exhibited poorer behavioral and cognitive functioning at baseline than controls. The groups did not differ in baseline white matter, amyloid-β, or tau, nor in behavioral and cognitive functioning, and tau accumulation change. Progression of white matter abnormalities of the uncinate fasciculus in Veterans with PTSD compared to controls was observed; analyses in TBI and PTSD+TBI were not run due to insufficient sample size. Conclusions: PTSD and PTSD+TBI negatively affect behavioral and cognitive functioning, while TBI does not contribute independently. Whether progressive decline in uncinate fasciculus microstructure in Veterans with PTSD might account for cognitive decline should be further studied. Findings did not support an association between PTSD, TBI, and Alzheimer’s disease pathology based on amyloid and tau PET.

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Section: Introductionmentioning

confidence: 99%

Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans

Marcolini,

Rojczyk,

Seitz-Holland

et al. 2023

JAD

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The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post‐Traumatic Stress Disorder

Hinostroza,

Mahr

2024

Brain and Behavior

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IntroductionThis extensive literature review investigates the relationship between post‐traumatic stress disorder (PTSD) and alcohol use disorder (AUD), focusing on the neurobiological changes associated with their co‐occurrence. Given that these disorders frequently coexist, we analyze mechanisms through which alcohol serves as a coping strategy for PTSD symptoms, particularly highlighting the drinking‐to‐cope self‐medication model, which suggests that alcohol use exacerbates PTSD symptoms and complicates recovery.MethodsA systematic literature search was conducted across multiple databases, including PubMed and Google Scholar, to identify studies examining the intersection of the biopsychosocial model with PTSD, AUD, and associated neural alterations.ResultsFindings demonstrate that chronic PTSD is associated with progressive dysfunction in the amygdala, hippocampus, prefrontal cortex, hypothalamic–pituitary–adrenal axis, and white matter pathways. Also, our findings underscore alterations within the reward system, prefrontal cortex, hippocampus, amygdala, basal ganglia, and hypothalamic–pituitary–adrenal axis that contribute to the pathophysiology of AUD. Our results support the notion that a biopsychosocial framework is essential for contemporary addiction treatment, particularly in the context of alcohol addiction and PTSD.ConclusionPTSD frequently leads individuals to use alcohol as a maladaptive coping strategy, ultimately resulting in neuroadaptive alterations across critical brain regions. These neurobiological changes contribute to the development and maintenance of AUD. The findings reiterate the necessity of employing a biopsychosocial model in treating individuals grappling with both PTSD and AUD. This model allows for a comprehensive understanding of the unique challenges faced by this population, integrating biological, psychological, and social factors that influence recovery.

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Aberrant white matter microstructure evaluation by automated fiber quantification in typhoon-related post-traumatic stress disorder

Cited by 2 publications

References 45 publications

Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans

Posttraumatic Stress and Traumatic Brain Injury: Cognition, Behavior, and Neuroimaging Markers in Vietnam Veterans

The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post‐Traumatic Stress Disorder

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