2015
DOI: 10.3892/mmr.2015.4025
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Aberrant Wnt/β-catenin signaling and elevated expression of stem cell proteins are associated with osteosarcoma side population cells of high tumorigenicity

Abstract: According to the cancer stem cell theory, the presence of a small sub-population of cancer cells, termed cancer stem cells (CSCs), have a significant implication on cancer treatment and are responsible for tumor recurrence. Previous studies have reported that alterations in the Wnt/β-catenin signaling are crucial in the maintenance of CSCs. In the present study, the characteristic features and activation of Wnt/β-catenin signaling in CSCs from osteosarcoma, an aggressive human bone tumor, were investigated. In… Show more

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Cited by 21 publications
(17 citation statements)
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“…However, the exact etiology of OS remains unknown. Although related surgical techniques and adjuvant chemotherapy have been improved, OS is still a primary cause of mortality for patients . It is reported that microRNAs (miRs) play vital roles in the tumors development and progression .…”
Section: Introductionmentioning
confidence: 99%
“…However, the exact etiology of OS remains unknown. Although related surgical techniques and adjuvant chemotherapy have been improved, OS is still a primary cause of mortality for patients . It is reported that microRNAs (miRs) play vital roles in the tumors development and progression .…”
Section: Introductionmentioning
confidence: 99%
“…In OS cell lines, the inactivation of NOTCH and WNT pathways resulted in sensitization to chemotherapeutic drugs [ 36 ]. In addition, aberrant active WNT/ β -catenin signaling has been described in the OS-CSC population and has been associated with SOX2 overexpression and tumorigenicity [ 38 , 132 ]. On the other hand, the WNT-antagonist Dickkopf proteins 1 (DKK1) has been proposed to enhance protumorigenic properties in OS, in part, through the upregulation of the stress response enzyme and CSC marker ALDH1A1 [ 133 ].…”
Section: Cancer Stem Cell Targeted Therapies In Osmentioning
confidence: 99%
“…3B). As increased expression of these genes is connected not only with "normal" stem cells but is also observed in "cancer" stem cells, [42][43][44] we also studied the influence of E-cadherin expression alterations on the proportion of cells with the CSCs traits in A549 cell sublines. For this purpose generally accepted approaches were used.…”
Section: Resultsmentioning
confidence: 99%