ABH and Lewis immunohistochemistry of the human eye

Pedal, I; Wetzel, Cornelia; Min, Jinsoo; Daus, W.

doi:10.1016/0379-0738(94)01630-n

Cited by 4 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that mucin-type O-glycans and N-glycans are expressed in the tear film and the ocular surface epithelia [15][16][17][18][19]. It was also reported that fucosylated glycans were expressed in normal corneas and conjunctivas [20][21][22][23], and their expression was upregulated in diseased corneas [23]. Given a range of functions of fucosylated glycans in physiologic and pathologic cellular processes, it is conceivable that fucosylation might play a role in ocular surface health and disease.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease

Yoon

Ryu

et al. 2021

IJMS

View full text Add to dashboard Cite

Fucosylation is involved in a wide range of biological processes from cellular adhesion to immune regulation. Although the upregulation of fucosylated glycans was reported in diseased corneas, its implication in ocular surface disorders remains largely unknown. In this study, we analyzed the expression of a fucosylated glycan on the ocular surface in two mouse models of dry eye disease (DED), the NOD.B10.H2b mouse model and the environmental desiccating stress model. We furthermore investigated the effects of aberrant fucosylation inhibition on the ocular surface and DED. Results demonstrated that the level of type 2 H antigen, an α(1,2)-fucosylated glycan, was highly increased in the cornea and conjunctiva both in NOD.B10.H2b mice and in BALB/c mice subjected to desiccating stress. Inhibition of α(1,2)-fucosylation by 2-deoxy-D-galactose (2-D-gal) reduced corneal epithelial defects and increased tear production in both DED models. Moreover, 2-D-gal treatment suppressed the levels of inflammatory cytokines in the ocular surface and the percentages of IFN-γ+CD4+ cells in draining lymph nodes, whereas it did not affect the number of conjunctival goblet cells, the MUC5AC level or the meibomian gland area. Together, the findings indicate that aberrant fucosylation underlies the pathogenesis of DED and may be a novel target for DED therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease

Yoon

Ryu

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

AB0-Blutgruppenexpression in Hornhäuten mit Transplantatversagen

et al. 2005

View full text Add to dashboard Cite

show abstract

The histo‐blood group ABO system and tissue transplantation

Eastlund¹

1998

Transfusion

127

View full text Add to dashboard Cite

In general, one might expect that ABO incompatibility of donor and recipient would be important to some degree if viability of the transplanted allograft is important for graft incorporation and function. This is true for some recipients of organs. However, ABO incompatibility appears to play a minor role, if any, in the clinical success of viable cornea and viable skin allografts. Even though A and B antigens may be present on the transplanted tissue, other factors that can contribute include the strength of the immune response, the avidity of the antibody, and the dose of the antigen presented, which may vary from donor to donor. Although A and B antigens are present on endothelium, the use of ABO-incompatible heart valves is successful, as they carry out their mechanical function by using the strength of the connective tissue rather than the viability of the donor endothelium. The presence, immunogenicity, and significance of A and B antigens in human vessel transplants have not been well studied. With the more commonly transplanted tissue, such as bone and tendon, posttransplant success does not depend on cellular viability or ABO compatibility.

show abstract

ABH and Lewis immunohistochemistry of the human eye

Cited by 4 publications

References 13 publications

Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease

Inhibition of Aberrant α(1,2)-Fucosylation at Ocular Surface Ameliorates Dry Eye Disease

AB0-Blutgruppenexpression in Hornhäuten mit Transplantatversagen

The histo‐blood group ABO system and tissue transplantation

Contact Info

Product

Resources

About