Abietane diterpenoids from Phlegmariurus carinatus and their biological activities

Lycopodium Alkaloids from Phlegmariurus carinatus with Cytotoxic and Neuroprotective Effects

“…The twelve known LAs (2-13) were identified as phlegmariurine B (2), [16,18] lycopodatine C (3), [19] lycoposerramine-K (4), [20] lycodine (5), lycophlegmarinine E (6), [21] huperzine A (7), huperzine C (8), [22] fawcettidine (9), lycoflexine (10), [23] 14,15-dehydrolycoflexine (11), carinatine A ( 12), and huperzine W (13) [24] by comparing the reported 1D NMR data in literature.…”

“…Some of these compounds showed various degrees of cytotoxic, anti‐AChE, and anti‐Parkinson's disease activities. In our previous study, seventeen abietane diterpenoids were isolated from this species, and their neuroprotective and cytotoxic activities were discussed [15,16] . As a result of our continuing search for structurally interesting and biologically significant metabolites from this plant, one new fawcettimine‐type LA ( 1 ), along with twelve known analogs ( 2 – 13 ), were further isolated and elucidated (Figure 1).…”

“…In our previous study, seventeen abietane diterpenoids were isolated from this species, and their neuroprotective and cytotoxic activities were discussed. [15,16] As a result of our continuing search for structurally interesting and biologically significant metabolites from this plant, one new fawcettimine-type LA (1), along with twelve known analogs (2-13), were further isolated and elucidated (Figure 1). Hence, this research reports the isolation, structure elucidation, and biological properties of all isolates.…”