Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity

Tóth, Barbara; Kúsz, Norbert; Forgó, Péter; Bózsity, Noémi; Zupkó, István; Pinke, Gyula; Hohmann, Judit; Vasas, Andrea

doi:10.1016/j.fitote.2017.08.016

Cited by 18 publications

(4 citation statements)

References 20 publications

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“…Few studies have investigated the antiproliferative potential of Sideritis spp. Tóth et al [ 41 ] examined the antiproliferative effects of isolated diterpenoids derived from Sideritis montana on human cancer cell lines (HeLa, SiHa, and C33A) by using MTT assay. Moreover, Tadić et al [ 42 ] investigated the cytotoxic effect of Sideritis scardica on PBMC, B16, and HL-60 cells, demonstrating also the potential anti-inflammatory effects of that extract.…”

Section: Resultsmentioning

confidence: 99%

Assessment of the Antimicrobial, Antioxidant, and Antiproliferative Potential of Sideritis raeseri subps. raeseri Essential Oil

Mitropoulou

Sidira²,

Skitsa

et al. 2020

Foods

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The aim of the present study was to investigate the antimicrobial potential of Sideritis raeseri subps. raeseri essential oil (EO) against common food spoilage and pathogenic microorganisms and evaluate its antioxidant and antiproliferative activity. The EO was isolated by steam distillation and analyzed by GC/MS. The main constituents identified were geranyl-p-cymene (25.08%), geranyl-γ-terpinene (15.17%), and geranyl-linalool (14.04%). Initially, its activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Listeria monocytogenes, Salmonella Enteritidis, Salmonella Typhimurium, Pseudomonas fragi, Saccharomyces cerevisiae, and Aspergillus niger was screened by the disk diffusion method. Subsequently, minimum inhibitory concentration (MIC), non-inhibitory concentration (NIC), and minimum lethal concentration (MLC) values were determined. Growth inhibition of all microorganisms tested was documented, although it was significantly lower compared to gentamycin, ciproxin, and voriconazole, which were used as positive controls. In a next step, its direct antioxidant properties were examined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, and the IC50 values were determined. The potential cytoprotective activity of the oil against H2O2–induced oxidative stress and DNA damage was studied in human immortalized keratinocyte (HaCaT) cells using the comet assay. Finally, the antiproliferative activity of the oil was evaluated against a panel of cancer cell lines including A375, Caco2, PC3, and DU145 and the non-cancerous HaCaT cell line using the sulforhodamine B (SRB) assay, and the EC50 values were determined. The oil demonstrated weak radical scavenging activity, noteworthy cytoprotective activity against H2O2–induced oxidative stress and DNA damage in HaCaT cells, and antiproliferative activity against all cell lines tested, being more sensitive against the in vitro model of skin melanoma.

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Section: Resultsmentioning

confidence: 99%

Assessment of the Antimicrobial, Antioxidant, and Antiproliferative Potential of Sideritis raeseri subps. raeseri Essential Oil

Mitropoulou

Sidira²,

Skitsa

et al. 2020

Foods

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“…Apart from the essential oil, S. montana is rich in phenolics (caffeic, ferulic, and rosmarinic acid), flavonoids and their derivatives (diosmetin, luteolin-3-O-glucoside, kaempferol-3-O-glucoside, kaempferol-3-O-rutinoside, pomiferin E, and 6-metoxysakuranetin), abietane diterpenoids (sideritins A and B, 9α,13α-epi-dioxyabiet-8(14)-en-18-ol), lignins (paulownin), sesquiterpenoids (3-oxo-α-ionol), phenyl-ethanoid glycosides (verbascoside), phenols (4-allyl-2,6-dimethoxyphenol glucoside), iridoids and their glycosides (ajugol, ajugoside, melittoside), coumarins, terpenes, and sterols (ergosterol, stigmasterol, β-sitosterol), among others [ 17 , 20 , 21 , 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…(66), 120 (38), 81 (35), 67 (31), 105 (29), 204 (29), 162 (25), 106 (23), 91 (21). NI-2: 107(100), 132 (50), 91 (34), 105 (34), 125 (30), 119 (29), 133 (29), 122 (28), 41 (23), 93 (22). NI-3: 109(100), 124(97), 81(94), 95 (74), 41 (65), 82 (58), 107 (55), 67 (54), 93 (48), 55 (46).…”

Section: Sideritis Montanamentioning

confidence: 99%

“…These results support the traditional use of S. montana for the healing and prevention of many diseases of modern times. Serbia: wound healing herb (aerial parts)/decoction, infusion/internally [9] Smooth muscle-relaxing methanol extract [27] Bulgaria: for relief of cough associated with cold ns [33] Antiproliferative (cervical cancer) and cytotoxic (melanoma, breast adenocarcinoma and human colon cancer) ethanol, methanol, hexane and ethyl acetate extracts, essential oil [17,22] Spain: digestive ns/infusion/internally [34] Antiinflammatory methanol extract [28] ns-not specified.…”

Section: Sideritis Montanamentioning

confidence: 99%

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Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia

et al. 2023

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Ironwort (Sideritis montana L.), mountain germander (Teucrium montanum L.), wall germander (Teucrium chamaedrys L.), and horehound (Marrubium peregrinum L.) are species widely distributed across Europe and are also found in North Africa and West Asia. Because of their wide distribution they express significant chemical diversity. For generations, these plants have been used as medical herbs for treating different aliments. The aim of this paper is to analyze volatile compounds of four selected species that belong to the subfamily Lamioideae, family Lamiaceae, and inspect scientifically proven biological activities and potential uses in modern phytotherapy in relation to traditional medicine. Therefore, in this research, we analyze the volatile compounds from this plants, obtained in laboratory by a Clevenger-type apparatus, followed by liquid–liquid extraction with hexane as the solvent. The identification of volatile compounds is conducted by GC-FID and GC-MS. Although these plants are poor in essential oil, the most abundant class of volatile components are mainly sesquiterpenes: germacrene D (22.6%) in ironwort, 7-epi-trans-sesquisabinene hydrate (15.8%) in mountain germander, germacrene D (31.8%) and trans-caryophyllene (19.7%) in wall germander, and trans-caryophyllene (32.4%) and trans-thujone (25.1%) in horehound. Furthermore, many studies show that, in addition to the essential oil, these plants contain phenols, flavonoids, diterpenes and diterpenoids, iridoids and their glycosides, coumarins, terpenes, and sterols, among other active compounds, which affect biological activities. The other goal of this study is to review the literature that describes the traditional use of these plants in folk medicine in regions where they grow spontaneously and compare them with scientifically confirmed activities. Therefore, a bibliographic search is conducted on Science Direct, PubMed, and Google Scholar to gather information related to the topic and recommend potential applications in modern phytotherapy. In conclusion, we can say that selected plants could be used as natural agents for promoting health, as a source of raw material in the food industry, and as supplements, as well as in the pharmaceutical industry for developing plant-based remedies for prevention and treatment of many diseases, especially cancer.

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Abietane‐Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential

Sargazifar,

Ghorbanian Charami,

Esmaeilzadeh Kashi

et al. 2024

Chemistry & Biodiversity

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The abietane‐type diterpenoids are among the most significant diterpene subsets found in hundreds of plant species belonging to various families. Among which, the members of the genus Salvia and Euphorbia are rich in abietane diterpenoids. Because of the chemical diversity and notable bioactivities, such as anticancer, antiinflammatory, antimicrobial, and antioxidant activities, abietane‐type diterpenoids are attractive. Herein, recent advances in the isolation and characterization of abietane‐type diterpenoids from natural sources, as well as their biological activities, from 2015 up to 2024 are reviewed. During this time, over 300 abietane diterpenoids with diverse structures have been discovered.

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Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity

Cited by 18 publications

References 20 publications

Assessment of the Antimicrobial, Antioxidant, and Antiproliferative Potential of Sideritis raeseri subps. raeseri Essential Oil

Assessment of the Antimicrobial, Antioxidant, and Antiproliferative Potential of Sideritis raeseri subps. raeseri Essential Oil

Screening of Volatile Compounds, Traditional and Modern Phytotherapy Approaches of Selected Non-Aromatic Medicinal Plants (Lamiaceae, Lamioideae) from Rtanj Mountain, Eastern Serbia

Abietane‐Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential

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