Abilities of berberine and chemically modified berberines to inhibit proliferation of pancreatic cancer cells

Abrams, Stephen L.; Follo, Marie; Steelman, Linda S.; Lertpiriyapong, Kvin; Cocco, Lucio; Ratti, Stefano; Martelli, Alberto M.; Candido, Saverio; Libra, Massimo; Murata, Ramiro Mendonça; Rosalen, Pedro Luiz; Montalto, Giuseppe; Cervello, Melchiorre; Gizak, Agnieszka; Rakus, Dariusz; Mao, Weifeng; Lombardi, Paolo; McCubrey, James A.

doi:10.1016/j.jbior.2018.10.003

Cited by 37 publications

(38 citation statements)

References 66 publications

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“…We have recently reviewed various modified BBR compounds that have been developed (McCubrey et al, 2017;Abrams et al, 2018;Abrams et al, 2019). In this current manuscript, we will summarize some novel advances in the field.…”

Section: Chemically-modified Bbrs-enhancing Effects Of Bbr By Medicinmentioning

confidence: 99%

“…PDAC cell lines were infected with either a retroviral vector encoding WT-TP53 or the empty pLXSN vector as a control as described (Abrams et al, , 2019. Stably infected cell lines were isolated in the presence of 2 mg/ml G418 (geneticin) Sigma-Aldrich.…”

Section: Infection Of Cells With a Retroviral Vector Encoding Wt-tp53mentioning

confidence: 99%

“…Stably infected cell lines were isolated in the presence of 2 mg/ml G418 (geneticin) Sigma-Aldrich. Pools were established after approximately four weeks in culture (Abrams et al, , 2019.…”

Section: Infection Of Cells With a Retroviral Vector Encoding Wt-tp53mentioning

confidence: 99%

“…Methylthiazole tetrazolium (MTT) assays were performed to determine the sensitivity of the pancreatic cancer cells to the modified NAX compounds and berberine as described (Abrams et al, , 2019.…”

Section: Methylthiazole Tetrazolium Assaysmentioning

confidence: 99%

“…Previously, we have summarized many of the key genetic and biological factors implicated in pancreatic cancer Abrams et al, 2018Abrams et al, , 2019McCubrey et al, 2018). Although various genetics and environmental factors may be involved in pancreatic cancer, few remedies have been developed to treat this devastating disease beyond surgery and chemotherapy which, unfortunately, only have minimal positive effects on patient survival.…”

Section: Introductionmentioning

confidence: 99%

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Abilities of berberine and chemically modified berberines to interact with metformin and inhibit proliferation of pancreatic cancer cells

Akula

Candido

Libra

et al. 2019

Advances in Biological Regulation

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A B S T R A C TPancreatic cancer is devastating cancer worldwide with few if any truly effective therapies. Pancreatic cancer has an increasing incidence and may become the second leading cause of death from cancer. Novel, more effective therapeutic approaches are needed as pancreatic cancer patients usually survive for less than a year after being diagnosed. Control of blood sugar levels by the prescription drug metformin in diseases such as diabetes mellitus has been examined in association with pancreatic cancer. While the clinical trials remain inconclusive, there is hope that certain diets and medications may affect positively the outcomes of patients with pancreatic and other cancers. Other natural compounds may share some of the effects of metformin. One "medicinal" fruit consumed by millions worldwide is berberine (BBR). Metformin and BBR both activate AMP-activated protein kinase (AMPK) which is a key mediator of glucose metabolism.

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Section: Chemically-modified Bbrs-enhancing Effects Of Bbr By Medicinmentioning

confidence: 99%

Section: Infection Of Cells With a Retroviral Vector Encoding Wt-tp53mentioning

confidence: 99%

“…Stably infected cell lines were isolated in the presence of 2 mg/ml G418 (geneticin) Sigma-Aldrich. Pools were established after approximately four weeks in culture (Abrams et al, , 2019.…”

Section: Infection Of Cells With a Retroviral Vector Encoding Wt-tp53mentioning

confidence: 99%

Section: Methylthiazole Tetrazolium Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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