Ability of 201Tl and 123I-BMIPP mismatch to diagnose myocardial ischemia in patients with suspected coronary artery disease

Nakamura, Ayako; Momose, Mitsuru; Kondo, Chisato; Nakajima, Takahito; Kusakabe, Kiyoko; Hagiwara, Nobuhisa

doi:10.1007/s12149-009-0307-8

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…SPECT probes include straight or branched chain fatty acid analogs labeled with radio iodine ( IBMIPP in the detection of acute and chronic is chemic events. [19][20][21][22] However, this agent might not reflect beta oxi dation to the same extent as the straight chain fatty acids. SPECT imaging with 123 IIPPA enables the evaluation of changes in beta oxidation under conditions of regional myocardial ischemia.…”

Section: Applicationsmentioning

confidence: 99%

PET and SPECT in cardiovascular molecular imaging

2009

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The current focus of cardiovascular medicine is on early detection and prevention of disease, to control the escalating costs of health care. To achieve this goal, novel imaging approaches that allow for early detection of disease and risk stratification are needed. Traditionally, the diagnosis, monitoring, and prognostication of cardiovascular disease were based on techniques that measured changes in metabolism, blood flow, and biological function. Molecular imaging is emerging as a new tool for the noninvasive detection of biological processes that can differentiate and characterize tissues before manifestation of gross anatomical features or physiological consequences. Leading the way are techniques involving high-sensitivity radiotracers that could revolutionize current diagnostic paradigms. This Review provides an overview of selected molecular-based single photon emission CT (SPECT) and PET imaging strategies for the evaluation of cardiovascular disease-including the evaluation of myocardial metabolism and neurohumoral activity of the heart-and potential future targeted methods of evaluating critical molecular processes, such as atherosclerosis, ventricular remodeling after myocardial infarction, and ischemia-associated angiogenesis.

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Section: Applicationsmentioning

confidence: 99%

PET and SPECT in cardiovascular molecular imaging

2009

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“…The utility of 123 I-BMIPP/ 201 TlCl mismatch for the diagnosis of coronary artery disease and as a predictor of cardiac events. [10] And the utility of 123 I-BMIPP/ 201 TlCl scintigraphy was reported in patients with dilated cardiomyopathy. [11] Despite the http://dx.doi.org/10.1097/MD.0000000000027173…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, in the ischemic environment created by vascular spasm, coronary blood flow is preserved and 201 TlCl accumulation does not change. The utility of 123 I-BMIPP/ 201 TlCl mismatch for the diagnosis of coronary artery disease and as a predictor of cardiac events [10] . And the utility of 123 I-BMIPP/ 201 TlCl scintigraphy was reported in patients with dilated cardiomyopathy [11] .…”

Section: Introductionmentioning

confidence: 99%

Usefulness of 123I-BMIPP and 201TlCl nuclide scintigraphy in evaluation of myocarditis in patients with polymyositis or dermatomyositis

et al. 2021

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To investigate the usefulness of 123 I-BMIPP/ 201 TlCl scintigraphy for evaluating the presence of myocarditis in patients with polymyositis (PM) or dermatomyositis (DM). We performed a retrospective study of 26 patients diagnosed with new-onset active PM/DM who underwent 123 I-BMIPP/ 201 TlCl scintigraphy between 01 April 2010 and 20 March 2015. We determined the 123 I-BMIPP/ 201 TlCl ratio and grouped the patients according to presence or absence of a mismatch. We evaluated the relationship between mismatch and the laboratory and echocardiographic findings. Mismatch was found in 13 (50%) patients. There was no statistically significant difference in age, cardiac troponin T, myoglobin, myosin light chain, aldolase levels, E wave/A wave ratio, right ventricular systolic pressure between the mismatch and non-mismatch groups. Left ventricular end-diastolic and end-systolic dimensions were significantly greater in the mismatch group (45.0 vs 42.5 mm, P = < .01 and 29.5 mm vs 25.0 mm, P < .01). Left ventricular ejection fraction was significantly lower in the mismatch group (63.5% vs 71.5%, P = .04). Significant inverse correlation (r = −0.44, P = .03) was observed between left ventricular ejection fraction and mismatch ratio. The use of 123 I-BMIPP/ 201 TlCl scintigraphy may be considered for evaluating myocarditis in patients with PM/DM.

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“…Therefore, ischemic heart diseases are frequently visualized by dual isotope imaging with a myocardial perfusion tracer such as 201 thallium, or 99m Tc-sestamibi (MIBI) [6]. Fatty acid metabolism is considered to decrease more rapidly than perfusion tracers when ischemia has occurred.…”

Section: Introductionmentioning

confidence: 99%