1985
DOI: 10.1016/s0140-6736(85)91615-0
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Ability of Calcium Bis Acetyl Homotaurine, a Gaba Agonist, to Prevent Relapse in Weaned Alcoholics

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Cited by 154 publications
(37 citation statements)
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“…Acamprosate has been shown to prevent relapse in weaned alcoholics (Lhuintre et al 1985;Sass et al 1996;Whitworth et al 1996) and to suppress alcohol consumption after a drug-free period in rats Hölter et al 1997;Heyser et al 1998). In view of the fact that alcohol and opioids share common properties at the behavioral and neurochemical levels (see Terenius 1996;Herz 1997 for review), we postulated that acamprosate might also interfere with processes involved in opioid dependence.…”
Section: Discussionmentioning
confidence: 94%
See 1 more Smart Citation
“…Acamprosate has been shown to prevent relapse in weaned alcoholics (Lhuintre et al 1985;Sass et al 1996;Whitworth et al 1996) and to suppress alcohol consumption after a drug-free period in rats Hölter et al 1997;Heyser et al 1998). In view of the fact that alcohol and opioids share common properties at the behavioral and neurochemical levels (see Terenius 1996;Herz 1997 for review), we postulated that acamprosate might also interfere with processes involved in opioid dependence.…”
Section: Discussionmentioning
confidence: 94%
“…Acamprosate (calcium-acetyl homotaurinate) is a new compound used for the prevention of relapse in abstinent alcoholics (Lhuintre et al 1985;Sass et al 1996;Whitworth et al 1996). It has also been shown that acamprosate reduces alcohol intake in rodents (Boismare et al 1984;Le Magnen et al 1987).…”
Section: Introductionmentioning
confidence: 99%
“…In this fashion, nine naltrexone studies (Anton et al, 1999;Chick et al, 2000a;Hersh et al, 1998;Kranzler et al, 1998Kranzler et al, , 2000O'Malley et al, 1992;Oslin et al, 1997;Volpicelli et al, 1992Volpicelli et al, , 1997 and 13 acamprosate studies (Besson et al, 1998;Chick et al, 2000b;Geerlings et al, 1997;Lhuintre et al, 1985Lhuintre et al, , 1990Paille et al, 1995;Pelc et al, 1992Pelc et al, , 1997Poldrugo, 1997;Roussaux et al, 1996;Sass et al, 1996;Tempesta et al, 2000;Whitworth et al 1996) were identified. The number of acamprosate studies was reduced to 11 by methodological concerns: Lhuintre et al (1985) reported data only on completers, and Lhuintre et al (1990) used only ␥-glutamyl transferase (GGT) as an outcome measure. Two studies of nalmefene, an opioid antagonist that has been studied as a treatment for alcohol dependence (Mason et al, 1994(Mason et al, , 1999, were not included in the analysis of naltrexone effects.…”
Section: Study Samplementioning
confidence: 98%
“…Following three early trials (Lhuintre et al 1985(Lhuintre et al , 1990Gerra et al 1992), five quite recent projects have further evaluated the value of acamprosate (Table 3). Paille et al (1995) conducted a 1-year, 31-site trial with 538 alcohol dependent patients in France.…”
Section: Acamprosatementioning
confidence: 99%