Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor

Efficient biotransformation of non-steroid anti-inflammatory drugs by endophytic and epiphytic fungi from dried leaves of a medicinal plant, Plantago lanceolata L.

“…Oxydative biotransformation of DIC and MEF also reduced the toxicity against a freshwater crustacean in (Hata et al, 2010). In contrast, during the metabolism of IBU into 1,2-dihydroxy-IBU by Trametes versicolor, increase in toxicity was observed in Microtox bioassay (Marco-Urrea et al, 2009b). The oxidized NSAIDs (as shown for DIC) can also give rise to toxic adduct-forming reactive species when metabolized further (Tang et al, 1999).…”

“…The same fungus was shown to successfully metabolize mefenamic acid into several oxidized products, like 3-OH-mefenamic acid and 3-COOH-mefenamic acid (Hata et al, 2010). The ibuprofen metabolism also consisted of oxidation (hydroxylation) steps in the case of Trametes versicolor, but the final product (1,2-dihydroxyibuprofen) was found to be new, and not previously described in biological systems (Marco-Urrea et al, 2009b). Production of 4'-hydroxy-diclofenac by a non-white-rot fungal strain, Epicoccum nigrum was described by (Webster et al, 1998).…”

Fungal Bioremediation of Emerging Micropollutants in Municipal Wastewaters

“…Trametes versicolor caused the decrease of 99% of parabens concentration after 2 days, together with a complete detoxification (Mizuno et al 2009). The great potential of T. versicolor strains was also confirmed in the effective removal of two sulfonamides, listed among the most widely used antibiotics (Rodriguez-Rodriguez et al 2012), ciprofloxacin and norfloxacin (Prieto et al 2011), and clofibric acid, ibuprofen and carbamazepine , Marco-Urrea et al 2009. Noteworthy among the four tested strains (T. versicolor, I. lacteus, Ganoderma lucidum and Phanerochaete chrysosporium), T. versicolor was the only one capable of converting clofibric acid and carbamazepine with high rates (91% and 58%, respectively) (Marco-…”

Pharmaceutical removal from water with iron- or manganese-based technologies: A review

“…In these processes, microorganisms can produce Fe-or Mn-oxides, which are used to remove pharmaceuticals by chemical oxidation. In addition, bacteria can work in advanced oxidation together with Fe which is known as biologically catalyzed advanced oxidation (Marco-Urrea et al, 2009;Gros et al, 2014).…”

“…The biological Fenton-like reaction occurs in the presence of lignin-derived quinone (2,6,-dimethoxy-1,4-benzoquinone, DBQ) and Fe 3C (Fig. 3) (Marco-Urrea et al, 2009;Gros et al, 2014). In this process, DBQ is reduced to hydroquinone (DBQH 2 ) in the presence of an intracellular quinone reductase produced from the fungi, followed by the generation of semiquinone radicals (DBQ ¡ ) via subsequent oxidation of DBQH 2 by lignin-modifying enzymes (laccases and peroxidases) which are also from the white-rot fungi.…”