2015
DOI: 10.1186/s40478-015-0194-2
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Ability of wild type mouse bioassay to detect bovine spongiform encephalopathy (BSE) in the presence of excess scrapie

Abstract: IntroductionScrapie and bovine spongiform encephalopathy (BSE) are transmissible spongiform encephalopathies (TSEs) which naturally affect small and large ruminants respectively. However, small ruminants, which are susceptible to BSE under experimental conditions, have been exposed to the same or similar contaminated food additives as cattle. To date two natural cases of BSE in small ruminants have been reported. As a result surveillance projects, combined with appropriate control measures, have been establish… Show more

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Cited by 4 publications
(5 citation statements)
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“…All dilutions of a single source were inoculated on the same day in reverse concentration order. Each mouse was inoculated intracerebrally with 20 µl of brain homogenate as described elsewhere (Corda et al, ). All animal procedures were performed according to the Animals (Scientific Procedures) Act 1986, Home Office License Number 70/6310.…”
Section: Methodsmentioning
confidence: 99%
“…All dilutions of a single source were inoculated on the same day in reverse concentration order. Each mouse was inoculated intracerebrally with 20 µl of brain homogenate as described elsewhere (Corda et al, ). All animal procedures were performed according to the Animals (Scientific Procedures) Act 1986, Home Office License Number 70/6310.…”
Section: Methodsmentioning
confidence: 99%
“…Cattle and sheep were inoculated intracerebrally or orally in the context of previous studies, as described elsewhere [ 18 , 33 , 36 38 ]. Mice were inoculated intracerebrally with 20 μl of TSE inoculum prepared from single-brain material at 10% (w/v) in saline as described previously [ 45 ]. All animal procedures were conducted in accordance with the UK Animal (Scientific Procedures) Act 1986 under license from the Government Home Office (Project Licence numbers 70/6781, and 70/7167 and 70/6892, for ruminant and murine procedures, respectively).…”
Section: Methodsmentioning
confidence: 99%
“…On the other hand, there were no appropriate animal models or limited animal models for the drug development research (Fernandez-Borges et al, 2013, Ghate et al, 2014, Shirai et al, 2014. In the last 20 years, several mouse models had been established and were used in a number of research fields of prion diseases, including pathology (Corda et al, 2015, Ghate et al, 2014 and genetics (Asante et al, 2015, Friedman-Levi et al, 2011. Through the last 35 years, less than 50 different drugs have been tested in different experimental animal models without any hope for the results.…”
Section: Prnp Polymorphisms In Six Mouse Strainsmentioning
confidence: 99%