Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study

Cano-García, Laura; Mena-Vázquez, Natalia; Manrique-Arija, Sara; Redondo-Rodríguez, Roció; Romero-Barco, Carmen María; Fernández‐Nebro, Antonio

doi:10.3390/diagnostics11122258

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…The PROMIS T‐scores for Ability to Participate was lower for individuals born before the introduction of prophylaxis, especially for severe hemophilia. This is consistent with PROMIS short form scores of a recent Spanish study among patients with rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus 41 . However, we found higher participation rates than for rheumatic disease patients, who had mean scores of 26.2 (SD 7.79).…”

Section: Discussionsupporting

confidence: 91%

“…This is consistent with PROMIS short form scores of a recent Spanish study among patients with rheumatoid arthritis, spondyloarthritis, and systemic lupus erythematosus. 41 However, we found higher participation rates than for rheumatic disease patients, who had mean scores of 26.2 (SD 7.79). In our study, scores of younger persons with nonsevere hemophilia were higher than in the general population.…”

Section: Discussioncontrasting

confidence: 55%

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Socioeconomic participation of persons with hemophilia: Results from the sixth hemophilia in the Netherlands study

Balen

Hassan

Smit

et al. 2022

Research and Practice in Thrombosis and Haemostasis

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Background and objectives Treatment availability and comprehensive care have resulted in improved clinical outcomes for persons with hemophilia. Recent data on socioeconomic participation in the Netherlands are lacking. This study assessed participation in education, in the labor market, and social participation for persons with hemophilia compared with the general male population. Methods Dutch adults and children (5–75 years) of all hemophilia severities ( n = 1009) participated in a questionnaire study that included sociodemographic, occupational, and educational variables. Clinical characteristics were extracted from electronic medical records. General population data were extracted from Statistics Netherlands. Social participation was assessed with the PROMIS Ability to Participate in Social Roles and Activities short form, with a minimal important difference set at 1.0. Results Data from 906 adults and children were analyzed. Participation in education of 20 to 24 year olds was 68% (general male population: 53%). Educational attainment was higher compared with Dutch males, especially for severe hemophilia. Absenteeism from school was more common than in the general population. The employment‐to‐population ratio and occupational disability were worse for severe hemophilia than in the general population (64.3% vs. 73.2% and 14.7% vs. 4.8%, respectively), but similar for nonsevere hemophilia. Unemployment was 5.4% (general male population: 3.4%). Absenteeism from work was less common (38% vs. 45.2%). Mean PROMIS score was similar to or higher than in the general population (54.2; SD 8.9 vs. 50; SD 10). Conclusion Socioeconomic participation of persons with nonsevere hemophilia was similar to the general male population. Some participation outcomes for persons with severe hemophilia were reduced.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 55%

Socioeconomic participation of persons with hemophilia: Results from the sixth hemophilia in the Netherlands study

Balen

Hassan

Smit

et al. 2022

Research and Practice in Thrombosis and Haemostasis

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“…We were unable to find studies published to date specifically on the association between dysphagia and MNA-SF. However, such an index could prove useful in SSc, since it has been validated in the general population and used in other autoimmune diseases, for example, rheumatoid arthritis 51…”

Section: Discussionmentioning

confidence: 99%

Severity and impact of digestive impairment perceived by patients with systemic sclerosis: a cross-sectional study

Cano-García,

Redondo-Rodríguez,

Mena-Vázquez

et al. 2024

BMJ Open

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ObjectivesTo describe the severity and impact of gastrointestinal involvement in patients with systemic sclerosis (SSc) and identify associated factors.Patients and methodsNon-controlled cross-sectional study of patients with SSc (2013 American College of Rheumatology/European League Against Rheumatism criteria). The main variables were severity of gastrointestinal involvement according to the University of California, Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 instrument (UCLA SCTC GIT 2.0) and dysphagia according to the Eating Assessment Tool-10 (EAT-10). We evaluated reflux, distension, diarrhoea, faecal soilage, constipation, emotional well-being and social functioning, as well as dysphagia. Clinical and epidemiological data were collected using the Mini Nutritional Assessment Short Form (MNA-SF) and the EuroQol-5D-3L. The degree of skin fibrosis was assessed using the modified Rodnan skin score (mRSS). Multivariate models were constructed to analyse factors associated with gastrointestinal involvement and dysphagia.ResultsOf the 75 patients with SSc included, 58.7% had moderate, severe or very severe reflux, 57.4% had constipation according to UCLA SCTC GIT 2.0 and 49.7% had abdominal distension. Gastrointestinal symptoms interfered significantly with social functioning (42.7%) and emotional well-being (40.0%). Dysphagia (EAT-10≥3) was recorded in 52% of patients, and according to MNA-SF poor nutrition in 30.7%, and clear malnutrition requiring a nutritional intervention in 5.3%. Multivariate adjustment revealed an association between severity of gastrointestinal symptoms according to the mRSS (β=0.249; p=0.002) and Visual Analogue Scale 3-Level EuroQol-5D (VAS-EQ-5D-3L) (β=–0.302; p=0.001), whereas presence of dysphagia was associated with the mRSS (OR=2.794; p=0.015), VAS-EQ-5D-3L (OR=0.950; p=0.005) and malnutrition (MNA-SF≤7; OR=3.920; p=0.041).ConclusionsPatients with SSc frequently present severe gastrointestinal symptoms. These are associated with poor quality of life, more severe skin involvement and malnutrition.

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“…Problems affecting concentration and executive functions may be caused by a depressive state, and this could lead to cognitive impairment [ 9 ]. Furthermore, in patients with inflammatory arthritis and autoimmune diseases, the frequency of depression has been reported to be increased [ 4 , 42 , 43 , 44 ], possibly as a result of various mechanisms, such as high levels of inflammatory mediators that negatively affect monoaminergic neural transmission, maintenance of synaptic plasticity, and physical inability to carry out activities of daily living owing to pain and inflammation [ 4 ]. In patients with JIA, fatigue and sleep problems are common [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Study of Cognitive Functioning in Adults with Juvenile Idiopathic Arthritis

et al. 2022

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Objective: To prospectively evaluate possible decline of cognitive functions in adult patients with juvenile idiopathic arthritis (JIA) and identify associated factors. Patients and methods: We performed a 24-month prospective observational study of adults (≥16 years) with JIA. The primary outcome measure was decline in cognitive function defined as a worsening of ≥2 points on the scales of the subsets administered to evaluate the different cognitive areas using the Wechsler Adult Intelligence Scale (WAIS) after 24 months: attention/concentration (digit span); verbal function (vocabulary); visual-spatial organization (block design); working memory (letter-number sequencing); and problem solving (similarities). Other variables included average inflammatory activity using C-reactive protein and composite activity indexes, comorbidity, and treatment. Logistic regression was performed to identify factors associated with cognitive decline. Results: The study population comprised 52 patients with JIA. Of these, 15 (28.8%) had cognitive decline at V24. The most affected functions were working memory (17.3%), attention/concentration (9.6%), verbal function (7.7%), visual-spatial organization (7.7%), and problem solving (3.8%). There were no significant differences in the median direct or scale scores for the cognitive functions evaluated between V0 and V24 for the whole sample. The factors associated with cognitive decline in patients with JIA were average C-reactive protein (OR [95% CI], 1.377 [1.060–1.921]; p = 0.039), depression (OR [95% CI], 3.691 [1.294–10.534]; p = 0.015), and treatment with biologics (OR [95% CI], 0.188 [0.039–0.998]; p = 0.046). Conclusion: Cognitive decline was detected in almost one third of adults with JIA after 24 months of follow-up. Systemic inflammatory activity in JIA patients was related to cognitive decline. Patients treated with biologics had a lower risk of decline in cognitive functions.

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Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study

Cited by 12 publications

References 33 publications

Socioeconomic participation of persons with hemophilia: Results from the sixth hemophilia in the Netherlands study

Socioeconomic participation of persons with hemophilia: Results from the sixth hemophilia in the Netherlands study

Severity and impact of digestive impairment perceived by patients with systemic sclerosis: a cross-sectional study

Longitudinal Study of Cognitive Functioning in Adults with Juvenile Idiopathic Arthritis

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