Ablation of Perivascular Hepatic Malignant Tumors with Irreversible Electroporation

Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: a single-center experience

“…However, according to de Baère et al (25) thrombosis of larger hepatic vessels is mainly associated with vascular occlusion (Pringle maneuver) in cirrhotic livers, which is used as supplement to RF ablation to avoid heat sink phenomena. The narrowing of hepatic vessels immediately after IRE ablation due to edematous and inflammatory changes has already been described previously (39.1%, 9/23 hepatic veins) (18), and even postablative portal vein thrombosis is a well-known complication after IRE ablation (3.2%, 1/31 ablation procedures) (22). The thrombotic alterations within the portal venous system in the current study may have been due to portal vein narrowing with reduced blood flow.…”

Maximizing Local Access to Therapeutic Deliveries in Glioblastoma. Part III: Irreversible Electroporation and High-Frequency Irreversible Electroporation for the Eradication of Glioblastoma

“…In addition to the treatment of brain tumors, IRE has been implemented to treat human patients with prostate (21,22), pancreatic (23)(24)(25), liver (26)(27)(28), and kidney (29,30) tumors. Benefits of IRE therapy include elimination of cytotoxic effects, sharp delineation between treated and spared tissue, a nonthermal mechanism of ablation, treatment planning abilities, sparing of nerves and major blood vessels (31,32), and, if desired, it can be used as a combinatorial treatment with CT and/or RT.…”

Electroporation: characteristics and therapeutic application of the method (a review)

“…На основании проведенного ана-лиза данных ультразвукового, клинико-лабораторного и па-тогистологического исследований доказана высокая эффек-тивность метода, а также безопасность его для сосудистых и протоковых структур печени [32]. Другими авторами в экс-периментах на свиньях и крысах также показано, что необ-ратимая электропорация вызывает абляцию тканей, не по-вреждая стенки крупных сосудов и эндотелий [33,34].…”

“…Необратимая электропорация приме-нялась при лечении 65 околососудистых злокачественных опухолей печени у 38 пациентов. Через 6 мес после абля-ции в 1 случае наблюдались остаточные изменения в опу-холи и в 3 -локальные рецидивы [34]. Имеются и другие сообщения об успешном применении электропорации и электрохимиотерапии при опухолях печени [38][39][40].…”